Crystal Structure of Human T Cell Leukemia Virus Type 1 gp21 Ectodomain Crystallized as a Maltose-Binding Protein Chimera Reveals Structural Evolution of Retroviral Transmembrane Proteins

Retroviral entry into cells depends on envelope glycoproteins, whereby receptor binding to the surface-exposed subunit triggers membrane fusion by the transmembrane protein (TM) subunit. We determined the crystal structure at 2.5- angstrom resolution of the ectodomain of gp21, the TM from human T ce...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1999-04, Vol.96 (8), p.4319-4324
Hauptverfasser:	Kobe, Bostjan, Rob J. Center, Kemp, Bruce E., Poumbourios, Pantelis
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS/HIV Amino Acid Sequence Biochemistry Biological Sciences Carrier Proteins - chemistry Carrier Proteins - isolation & purification Cell membranes Chimeras Computer Graphics Crystal structure Crystallization Crystallography, X-Ray - methods env Gene Products, Human Immunodeficiency Virus Evolution, Molecular Gene Products, env - chemistry Gene Products, env - genetics Gene Products, env - isolation & purification HIV 1 Human T lymphotropic virus 1 Human T-lymphotropic virus 1 - chemistry Human T-lymphotropic virus 1 - genetics Humans Leukemia Macromolecular Substances Maltose-Binding Proteins Membranes Models, Molecular Molecular Sequence Data Protein Structure, Secondary Proteins Recombinant Fusion Proteins - chemistry Recombinant Fusion Proteins - isolation & purification Retroviridae Retroviridae Proteins, Oncogenic - chemistry Retroviridae Proteins, Oncogenic - genetics Retroviridae Proteins, Oncogenic - isolation & purification Sequence Alignment Sequence Homology, Amino Acid Trimers Viral morphology Viruses
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