Separation of β-Blocker Enantiomers on Silica Modified with Gold Nanoparticles with Immobilized Macrocyclic Antibiotic Vancomicin
A new chiral sorbent based on mercaptosilica modified by gold nanoparticles, then treated by 3-mercaptopropionic acid and macrocyclic antibiotic vancomycin, was obtained. The enantioseparation of isomeric β-blockers (nadolol, atenolol, metoprolol, alprenolol, oxprenolol, and pindolol) by HPLC was st...
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| Veröffentlicht in: | Journal of analytical chemistry (New York, N.Y.) N.Y.), 2018-02, Vol.73 (2), p.152-159 |
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| container_title | Journal of analytical chemistry (New York, N.Y.) |
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| creator | Anan’eva, I. A. Polyakova, Ya. A. Shapovalova, E. N. Mazhuga, A. G. Shpigun, O. A. |
| description | A new chiral sorbent based on mercaptosilica modified by gold nanoparticles, then treated by 3-mercaptopropionic acid and macrocyclic antibiotic vancomycin, was obtained. The enantioseparation of isomeric β-blockers (nadolol, atenolol, metoprolol, alprenolol, oxprenolol, and pindolol) by HPLC was studied on the synthesized sorbent. The effect of the composition of the mobile phase (nature and concentration of the organic solvent, concentration and pH of the buffer solution) on retention times of β-blocker enantiomers, selectivity of separation, and resolution of chromatographic peaks were studied. The best separation was achieved for pindolol and metoprolol. The procedure was used to determine the pindolol enantiomers in the preparation “Visken,” and metoprolol in the “Vazocardin” preparation. |
| doi_str_mv | 10.1134/S1061934818020028 |
| format | Article |
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The procedure was used to determine the pindolol enantiomers in the preparation “Visken,” and metoprolol in the “Vazocardin” preparation.</description><identifier>ISSN: 1061-9348</identifier><identifier>EISSN: 1608-3199</identifier><identifier>DOI: 10.1134/S1061934818020028</identifier><language>eng</language><publisher>Moscow: Pleiades Publishing</publisher><subject>Analytical Chemistry ; Antibiotics ; Buffer solutions ; Chemistry ; Chemistry and Materials Science ; Composition effects ; Enantiomers ; Gold ; High performance liquid chromatography ; Nanoparticles ; Separation ; Silicon dioxide ; Vancomycin</subject><ispartof>Journal of analytical chemistry (New York, N.Y.), 2018-02, Vol.73 (2), p.152-159</ispartof><rights>Pleiades Publishing, Ltd. 2018</rights><rights>Copyright Springer Science & Business Media 2018</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c316t-af6fee09a3f90f909c8e03cf267f319280b0c929d8e52d33bf0c90f871dbdc8e3</citedby><cites>FETCH-LOGICAL-c316t-af6fee09a3f90f909c8e03cf267f319280b0c929d8e52d33bf0c90f871dbdc8e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1134/S1061934818020028$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1134/S1061934818020028$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids></links><search><creatorcontrib>Anan’eva, I. 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The effect of the composition of the mobile phase (nature and concentration of the organic solvent, concentration and pH of the buffer solution) on retention times of β-blocker enantiomers, selectivity of separation, and resolution of chromatographic peaks were studied. The best separation was achieved for pindolol and metoprolol. The procedure was used to determine the pindolol enantiomers in the preparation “Visken,” and metoprolol in the “Vazocardin” preparation.</description><subject>Analytical Chemistry</subject><subject>Antibiotics</subject><subject>Buffer solutions</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Composition effects</subject><subject>Enantiomers</subject><subject>Gold</subject><subject>High performance liquid chromatography</subject><subject>Nanoparticles</subject><subject>Separation</subject><subject>Silicon dioxide</subject><subject>Vancomycin</subject><issn>1061-9348</issn><issn>1608-3199</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp1kMFKAzEQhhdRsFYfwFvA8-pk090mx1pqLbR6qHpdstlEU3eTmmyRevSRfBCfyZEKHkQIJDP_9_9JJklOKZxTygYXSwoFFWzAKYcMION7SY8WwFNGhdjHM8rpt36YHMW4AgDBadFL3pd6LYPsrHfEG_L5kV42Xj3rQCZOOmy3OkSC4tI2Vkmy8LU1Vtfk1XZPZOqbmtxI5zGjs6rRcdefta2v0PCG4EKq4NVWoZ2MMLGyHlHyIJ3yrVXWHScHRjZRn_zs_eT-anI3vk7nt9PZeDRPFaNFl0pTGK1BSGYE4BKKa2DKZMXQ4CczDhUokYma6zyrGasMlmD4kNZVjSzrJ2e73HXwLxsdu3LlN8HhlWUGlNE853mBFN1R-OoYgzblOthWhm1Jofwedfln1OjJdp6IrHvU4Tf5f9MXIQuDCw</recordid><startdate>20180201</startdate><enddate>20180201</enddate><creator>Anan’eva, I. 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The effect of the composition of the mobile phase (nature and concentration of the organic solvent, concentration and pH of the buffer solution) on retention times of β-blocker enantiomers, selectivity of separation, and resolution of chromatographic peaks were studied. The best separation was achieved for pindolol and metoprolol. The procedure was used to determine the pindolol enantiomers in the preparation “Visken,” and metoprolol in the “Vazocardin” preparation.</abstract><cop>Moscow</cop><pub>Pleiades Publishing</pub><doi>10.1134/S1061934818020028</doi><tpages>8</tpages></addata></record> |
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| source | SpringerNature Journals |
| subjects | Analytical Chemistry Antibiotics Buffer solutions Chemistry Chemistry and Materials Science Composition effects Enantiomers Gold High performance liquid chromatography Nanoparticles Separation Silicon dioxide Vancomycin |
| title | Separation of β-Blocker Enantiomers on Silica Modified with Gold Nanoparticles with Immobilized Macrocyclic Antibiotic Vancomicin |
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