Unusual phenotypic alteration of beta amyloid precursor protein (betaAPP) maturation by a new Val-715 leads to Met betaAPP-770 mutation responsible for probable early-onset Alzheimer's disease

Unusual phenotypic alteration of beta amyloid precursor protein (betaAPP) maturation by a new Val-715 leads to Met betaAPP-770 mutation responsible for probable early-onset Alzheimer's disease

We have identified a novel Beta amyloid precursor protein (BetaAPP) mutation (V715M-BetaAPP770) that cosegregates with early-onset Alzheimer's disease (AD) in a pedigree.

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Veröffentlicht in:Proceedings of the National Academy of Sciences - PNAS 1999-03, Vol.96 (7), p.4119
Hauptverfasser: Ancolio, K, Dumanchin, C, Barelli, H, Warter, J M
Format: Artikel
Sprache:eng
Schlagworte:
Alzheimer's disease
Mutation
Neurons
Proteins
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Zusammenfassung:We have identified a novel Beta amyloid precursor protein (BetaAPP) mutation (V715M-BetaAPP770) that cosegregates with early-onset Alzheimer's disease (AD) in a pedigree.
ISSN:0027-8424
1091-6490