The E5 Gene Product of Rhesus Papillomavirus is an Activator of Endogenous Ras and phosphatidylinositol-3′-kinase in NIH 3T3 Cells

We examined the effect of two rhesus papillomavirus 1 (RhPV) oncogenes on cytokine-induced signal transduction pathways leading to the possible activation of Ras protein (p21ras) and phosphatidylinositol kinase. p21rasin both the activated (GTP-bound) and inactivated (GDP-bound) states were quantita...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1996-11, Vol.93 (23), p.12879-12884
Hauptverfasser:	Ghai, Jyotsna, Ostrow, Ronald S., Tolar, Jakub, McGlennen, Ronald C., Lemke, Todd D., Tobolt, Diane, Liu, Zhanjiang, Faras, Anthony J.
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 Cells Animals Antibodies Biochemistry Biological Sciences Cattle Cell growth Cell lines Cell Transformation, Neoplastic Cellular biology Enzyme Activation ErbB Receptors - biosynthesis ErbB Receptors - metabolism Genes Genes, Viral Growth factor receptors Guanosine Diphosphate - metabolism Guanosine Triphosphate - metabolism Humans Macaca Mice NIH 3T3 cells Papillomaviridae - genetics Papillomaviridae - metabolism Phosphatidylinositol 3-Kinases Phosphorylation Phosphotransferases (Alcohol Group Acceptor) - metabolism Proteins Proto-Oncogene Proteins p21(ras) - metabolism Receptors Recombinant Proteins - biosynthesis Recombinant Proteins - metabolism Swiss 3T3 cells Transfection Transformed cell line Viral Proteins - biosynthesis Viral Proteins - metabolism Viruses
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