Rapid Nongenomic Actions of Thyroid Hormone

The binding of thyroid hormone to the thyroid hormone receptor (TR) mediates important physiological effects. However, the transcriptional effects of TR mediated by the thyroid response element (TRE) cannot explain many actions of thyroid hormone. We postulate that TR can initiate rapid, non-TRE-med...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2006-09, Vol.103 (38), p.14104-14109
Hauptverfasser:	Hiroi, Yukio, Kim, Hyung-Hwan, Ying, Hao, Furuya, Fumihiko, Huang, Zhihong, Simoncini, Tommaso, Noma, Kensuke, Ueki, Kojiro, Nguyen, Ngoc-Ha, Scanlan, Thomas S., Moskowitz, Michael A., Cheng, Sheue-Yann, Liao, James K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies Biological Sciences Blood Pressure - physiology Boluses Cardiovascular system Cattle Cells, Cultured Cerebral Infarction - pathology Cerebrovascular Circulation Endothelial cells Endothelial Cells - cytology Endothelial Cells - metabolism Enzyme Activation HeLa cells Hormones Human umbilical vein endothelial cells Humans Mice Mice, Inbred C57BL Mice, Knockout Neuroprotective Agents - metabolism Nitric Oxide Synthase Type III - genetics Nitric Oxide Synthase Type III - metabolism Nitrites Phosphatidylinositol 3-Kinases - metabolism Phosphorylation Protein isoforms Protein Isoforms - genetics Protein Isoforms - metabolism Proto-Oncogene Proteins c-akt - metabolism Rats Receptors, Thyroid Hormone - genetics Receptors, Thyroid Hormone - metabolism Strokes Thyroid gland Thyroid hormones Thyroid Hormones - metabolism Triiodothyronine - metabolism
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