A Single Zinc Finger Motif in the Silencing Factor REST Represses the Neural-Specific Type II Sodium Channel Promoter

The type II voltage-dependent sodium channel is present in neuronal cells, where it mediates the propagation of nerve impulses. Restricted expression of the type II sodium channel gene to neurons is due, at least in part, to binding of the repressor protein REST (also termed NRSF or XBR) to the RE1...

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