Directed selection of a conformational antibody domain that prevents mature amyloid fibril formation by stabilizing Aß protofibrils

The formation of amyloid fibrils is a common biochemical characteristic that occurs in Alzheimer's disease and several other amyloidoses. The unifying structural feature of amyloid fibrils is their specific type of β-sheet conformation that differentiates these fibrils from the products of norm...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2007-12, Vol.104 (49), p.19232
Hauptverfasser:	Habicht, Gernot, Haupt, Christian, Friedrich, Ralf P, Hortschansky, Peter, Sachse, Carsten, Meinhard, Jessica, Wieligmann, Karin, Gellermann, Gerald P, Brodhun, Michael, Götz, Jürgen, Halbhuber, Karl-Jürgen, Röcken, Christoph, Horn, Uwe, Fändrich, Marcus
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer's disease Biochemistry Immune system Neurology Peptides Prions
Online-Zugang:	Volltext
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