Arachidonate Lipoxygenases as Essential Regulators of Cell Survival and Apoptosis

Arachidonic acid (AA) metabolites derived from both cyclooxygenase (COX) and lipoxygenase (LOX) pathways transduce a variety of signals related to cell growth. Here, we report that the AA LOX pathway also functions as a critical regulator of cell survival and apoptosis. Rat Walker 256 (W256) carcino...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1996-05, Vol.93 (11), p.5241-5246
Hauptverfasser:	Tang, Dean G., Chen, Yong Q., Honn, Kenneth V.
Format:	Artikel
Sprache:	eng
Schlagworte:	12-Hydroxy-5,8,10,14-eicosatetraenoic Acid Animals Antisense oligonucleotides Apoptosis Apoptosis - drug effects Apoptosis - physiology Arachidonate 12-Lipoxygenase - biosynthesis Arachidonate 12-Lipoxygenase - metabolism Base Sequence Biochemistry Cell death Cell Division - drug effects Cell Line Cell Survival - drug effects Cell Survival - physiology Cells Cellular biology Cellular metabolism DNA DNA fragmentation Enzymes Female Gene expression regulation Homeostasis Hydroxyeicosatetraenoic Acids - pharmacology Leukotriene B4 - pharmacology Leukotriene C4 - pharmacology Leukotrienes - pharmacology Lipid Peroxides - pharmacology Lipoxins Masoprocol - pharmacology Microelectromechanical systems Molecular Sequence Data Oligonucleotides Oligonucleotides, Antisense - pharmacology Plasmids Rats Transfection
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