Requirement of Poly (ADP-Ribose) Polymerase in Recovery from DNA Damage in Mice and in Cells

Poly(ADP-ribose) polymerase [PARP; NAD+ADP-ribosyltransferase; NAD+; poly(adenosine-diphosphate-D-ribosyl)-acceptor ADP-D-ribosyltransferase, EC 2.4.2.30] is a zinc-finger DNA-binding protein that detects specifically DNA strand breaks generated by genotoxic agents. To determine its biological funct...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1997-07, Vol.94 (14), p.7303-7307
Hauptverfasser:	De Murcia, Josiane Menissier, Niedergang, Claude, Trucco, Carlotta, Ricoul, Michele, Dutrillaux, Bernard, Mark, Manuel, Oliver, F. Javier, Masson, Murielle, Dierich, Andree, LeMeur, Marianne, Walztinger, Caroline, Chambon, Pierre, De Murcia, Gilbert
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Animals Apoptosis Apoptosis - physiology Biochemistry, Molecular Biology Biological Sciences Bone marrow cells Cell Cycle Cell Cycle - physiology Cells Cells, Cultured Cellular biology Chromatids Deoxyribonucleic acid DNA DNA Damage Epithelial cells Female Fibroblasts Gene Targeting Genetics Life Sciences Mice Mutation Poly(ADP-ribose) Polymerases Poly(ADP-ribose) Polymerases - physiology Pregnancy Rodents Splenocytes Structural Biology
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