Brain-Derived Neurotrophic Factor Rapidly Enhances Synaptic Transmission in Hippocampal Neurons via Postsynaptic Tyrosine Kinase Receptors

Although neurotrophins are primarily associated with long-term effects on neuronal survival and differentiation, recent studies have shown that acute changes in synaptic transmission can also be produced. In the hippocampus, an area critically involved in learning and memory, we have found that brai...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1995-08, Vol.92 (17), p.8074-8077
Hauptverfasser:	Levine, Eric S., Dreyfus, Cheryl F., Black, Ira B., Plummer, Mark R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Action potentials Animals Biology Brain Brain-Derived Neurotrophic Factor Carbazoles - pharmacology Cell culture techniques Cells, Cultured Electric current Embryo, Mammalian Ethers, Cyclic - pharmacology Evoked Potentials - drug effects Evoked Potentials - physiology Hippocampus Hippocampus - physiology Indole Alkaloids Kinetics Nerve Growth Factors - pharmacology Nerve Tissue Proteins - pharmacology Neurology Neurons Neurons - drug effects Neurons - physiology Neuroscience Okadaic Acid Patch-Clamp Techniques Protein Kinase C - antagonists & inhibitors Protein Tyrosine Phosphatases - antagonists & inhibitors Pyramidal cells Rats Rats, Sprague-Dawley Receptor Protein-Tyrosine Kinases - metabolism Receptors Synapses - drug effects Synapses - physiology Synaptic transmission Synaptic Transmission - drug effects Time Factors
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