Crystal Structure of Human T Cell Leukemia Virus Protease, a Novel Target for Anticancer Drug Design

The successful development of a number of HIV-1 protease (PR) inhibitors for the treatment of AIDS has validated the utilization of retroviral PRs as drug targets and necessitated their detailed structural study. Here we report the structure of a complex of human T cell leukemia virus type 1 (HTLV-1...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2005-12, Vol.102 (51), p.18332-18337
Hauptverfasser:	Li, Mi, Laco, Gary S., Jaskolski, Mariusz, Jan Rozycki, Alexandratos, Jerry, Wlodawer, Alexander, Alla Gustchina, Davies, David R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Anti HIV agents Anti-HIV Agents - chemistry Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Aspartic Acid Endopeptidases - antagonists & inhibitors Aspartic Acid Endopeptidases - chemistry Aspartic Acid Endopeptidases - metabolism Atoms Biochemistry Biological Sciences Crystallography, X-Ray Dimers Drug Design Enzymes HIV 1 HIV 2 Human immunodeficiency virus Human immunodeficiency virus 1 Human T lymphotropic virus 1 Human T-lymphotropic virus 1 - enzymology Humans Hydrogen bonds Inhibitor drugs Leukemia Models, Molecular Molecular Sequence Data Molecules Monomers Protease inhibitors Protease Inhibitors - chemistry Proteases Protein Structure, Tertiary Sequence Alignment Sequence Homology, Amino Acid Structural Homology, Protein
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