Expression of BCR/ABL and BCL-2 in Myeloid Progenitors Leads to Myeloid Leukemias

Chronic myelogenous leukemia is a myeloproliferative disorder (MPD) that, over time, progresses to acute leukemia. Both processes are closely associated with the t(9;22) chromosomal translocation that creates the BCR/ABL fusion gene in hematopoietic stem cells (HSCs) and their progeny. Chronic myelo...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2003-08, Vol.100 (17), p.10002-10007
Hauptverfasser:	Jaiswal, Siddhartha, Traver, David, Miyamoto, Toshihiro, Akashi, Koichi, Lagasse, Eric, Weissman, Irving L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis B lymphocytes Biological Sciences Blood Bone marrow Chronic myeloid leukemia Crosses, Genetic Disease Models, Animal Female Gene Expression Genes, abl Genes, bcl-2 Hematopoietic stem cells Humans Leukemia Leukemia, Myelogenous, Chronic, BCR-ABL Positive - etiology Leukemia, Myelogenous, Chronic, BCR-ABL Positive - genetics Leukemia, Myelogenous, Chronic, BCR-ABL Positive - pathology Male Mice Mice, Inbred C57BL Mice, Transgenic Mutation Myeloid Progenitor Cells - metabolism Myeloid Progenitor Cells - pathology Neutrophils Progenitor cells Rodents Stem cells Transgenic animals
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