Cytoplasmically Sequestered Wild-Type p53 Protein in Neuroblastoma is Relocated to the Nucleus by a C-Terminal Peptide

Cytoplasmic sequestration of wild-type p53 protein occurs in a subset of primary human tumors including breast cancer, colon cancer, and neuroblastoma (NB). The sequestered p53 localizes to punctate cytoplasmic structures that represent large protein aggregates. One functional consequence of this bl...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1996-12, Vol.93 (26), p.15190-15194
Hauptverfasser:	Ostermeyer, Anne G., Runko, Erik, Winkfield, Blonka, Ahn, Brand, Moll, Ute M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Animals Binding Sites Biological Sciences Brain Neoplasms Breast Neoplasms Cell Cycle Cell Line Cell lines Cell nucleus Cell Nucleus - metabolism Cells Cellular biology Colonic Neoplasms Cytoplasm - metabolism Deoxyribonucleic acid DNA DNA Damage DNA, Neoplasm - chemistry DNA, Neoplasm - metabolism Female Fluorescent antibody techniques Gels Humans Mice Neuroblastoma Oligodeoxyribonucleotides Peptide Fragments - chemistry Peptide Fragments - isolation & purification Peptide Fragments - metabolism Peptides Proteins Recombinant Proteins - chemistry Recombinant Proteins - isolation & purification Recombinant Proteins - metabolism Tumor Cells, Cultured Tumor Suppressor Protein p53 - chemistry Tumor Suppressor Protein p53 - isolation & purification Tumor Suppressor Protein p53 - metabolism
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