Evaluation of the Influence of Three Newly Developed Bispyridinium Anti‐nicotinic Compounds (MB408, MB442, MB444) on the Efficacy of Antidotal Treatment of Nerve Agent Poisoning in Mice

The influence of three newly developed bispyridinium antinicotinic compounds (the non‐oximes MB408, MB442 and MB444) on the therapeutic efficacy of a standard antidotal treatment (atropine in combination with an oxime) of acute poisoning by the organophosphorus nerve agents tabun and soman was studi...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Basic & clinical pharmacology & toxicology 2018-04, Vol.122 (4), p.429-435
Hauptverfasser: Kassa, Jiri, Timperley, Christopher M., Bird, Mike, Williams, Rebecca L., Green, A. Christopher, Tattersall, John E. H.
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 435
container_issue 4
container_start_page 429
container_title Basic & clinical pharmacology & toxicology
container_volume 122
creator Kassa, Jiri
Timperley, Christopher M.
Bird, Mike
Williams, Rebecca L.
Green, A. Christopher
Tattersall, John E. H.
description The influence of three newly developed bispyridinium antinicotinic compounds (the non‐oximes MB408, MB442 and MB444) on the therapeutic efficacy of a standard antidotal treatment (atropine in combination with an oxime) of acute poisoning by the organophosphorus nerve agents tabun and soman was studied in mice. The therapeutic efficacy of atropine in combination with an oxime with or without one of the bispyridinium non‐oximes was evaluated by determination of the LD50 values of the nerve agents and measurement of the survival time after supralethal poisoning. Addition of all the tested non‐oximes increased significantly the therapeutic efficacy of atropine in combination with an oxime against tabun poisoning. They also positively influenced the number of surviving mice 6 hr after supralethal poisoning with tabun. However, they were only slightly effective for the treatment of soman poisoning. The benefit of the tested bispyridinium non‐oximes was dose‐dependent. To conclude, the addition of bispyridinium non‐oximes to the standard antidotal treatment of acute poisoning with tabun was beneficial regardless of the chosen non‐oxime, but only slightly beneficial in the case of soman poisoning.
doi_str_mv 10.1111/bcpt.12935
format Article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_2012858078</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2012858078</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3935-14f46f3c9a203eb396c0293143fbd22bb822c12b6a74c3bb4569e5985588af8a3</originalsourceid><addsrcrecordid>eNp9Uc1u1DAYtBCIloULD4AscQHULf7L33F3uy2V2tLDco4c53PrKrGDnWyVWx-B9-FteJI6pPSIL-NvNJqRZhB6T8kxje9rpbr-mLKCJy_QIc0EW2a54C-f_zw5QG9CuCOEZYKS1-iAFZRmKU8O0e_tXjaD7I2z2Gnc3wI-t7oZwCqYiN2tB8BXcN-M-AT20LgOarw2oRu9qY01Q4tXtjd_Hn5Zo1wfGYU3ru3cYOuAP12uBcmPcATBZhCfccyagrZaGyXVOOVMHrXrZYN3HmTfgu0n-gr8HvDqZjqvnQnOGnuDjcWXRsFb9ErLJsC7J1ygH6fb3ebb8uL72flmdbFUPHaypEKLVHNVSEY4VLxIFYllUcF1VTNWVTljirIqlZlQvKpEkhaQFHmS5LnUueQL9HH27bz7OUDoyzs3eBsjS0Yoy5OcxJIX6MusUt6F4EGXnTet9GNJSTntVE47lX93iuIPT5ZD1UL9LP03TBTQWXBvGhj_Y1WuN9e72fQRA5Kdiw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2012858078</pqid></control><display><type>article</type><title>Evaluation of the Influence of Three Newly Developed Bispyridinium Anti‐nicotinic Compounds (MB408, MB442, MB444) on the Efficacy of Antidotal Treatment of Nerve Agent Poisoning in Mice</title><source>Wiley Online Library Journals Frontfile Complete</source><source>Alma/SFX Local Collection</source><creator>Kassa, Jiri ; Timperley, Christopher M. ; Bird, Mike ; Williams, Rebecca L. ; Green, A. Christopher ; Tattersall, John E. H.</creator><creatorcontrib>Kassa, Jiri ; Timperley, Christopher M. ; Bird, Mike ; Williams, Rebecca L. ; Green, A. Christopher ; Tattersall, John E. H.</creatorcontrib><description>The influence of three newly developed bispyridinium antinicotinic compounds (the non‐oximes MB408, MB442 and MB444) on the therapeutic efficacy of a standard antidotal treatment (atropine in combination with an oxime) of acute poisoning by the organophosphorus nerve agents tabun and soman was studied in mice. The therapeutic efficacy of atropine in combination with an oxime with or without one of the bispyridinium non‐oximes was evaluated by determination of the LD50 values of the nerve agents and measurement of the survival time after supralethal poisoning. Addition of all the tested non‐oximes increased significantly the therapeutic efficacy of atropine in combination with an oxime against tabun poisoning. They also positively influenced the number of surviving mice 6 hr after supralethal poisoning with tabun. However, they were only slightly effective for the treatment of soman poisoning. The benefit of the tested bispyridinium non‐oximes was dose‐dependent. To conclude, the addition of bispyridinium non‐oximes to the standard antidotal treatment of acute poisoning with tabun was beneficial regardless of the chosen non‐oxime, but only slightly beneficial in the case of soman poisoning.</description><identifier>ISSN: 1742-7835</identifier><identifier>EISSN: 1742-7843</identifier><identifier>DOI: 10.1111/bcpt.12935</identifier><identifier>PMID: 29117635</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Atropine ; Biological &amp; chemical weapons ; Effectiveness ; Mice ; Nerve agents ; Oximes ; Poisoning ; Pyridinium ; Reagents ; Soman ; Tabun</subject><ispartof>Basic &amp; clinical pharmacology &amp; toxicology, 2018-04, Vol.122 (4), p.429-435</ispartof><rights>2017 Nordic Association for the Publication of BCPT (former Nordic Pharmacological Society)</rights><rights>2017 Nordic Association for the Publication of BCPT (former Nordic Pharmacological Society).</rights><rights>Copyright © 2018 Nordic Association for the Publication of BCPT (former Nordic Pharmacological Society). Published by John Wiley &amp; Sons Ltd</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3935-14f46f3c9a203eb396c0293143fbd22bb822c12b6a74c3bb4569e5985588af8a3</citedby><cites>FETCH-LOGICAL-c3935-14f46f3c9a203eb396c0293143fbd22bb822c12b6a74c3bb4569e5985588af8a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fbcpt.12935$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fbcpt.12935$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29117635$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kassa, Jiri</creatorcontrib><creatorcontrib>Timperley, Christopher M.</creatorcontrib><creatorcontrib>Bird, Mike</creatorcontrib><creatorcontrib>Williams, Rebecca L.</creatorcontrib><creatorcontrib>Green, A. Christopher</creatorcontrib><creatorcontrib>Tattersall, John E. H.</creatorcontrib><title>Evaluation of the Influence of Three Newly Developed Bispyridinium Anti‐nicotinic Compounds (MB408, MB442, MB444) on the Efficacy of Antidotal Treatment of Nerve Agent Poisoning in Mice</title><title>Basic &amp; clinical pharmacology &amp; toxicology</title><addtitle>Basic Clin Pharmacol Toxicol</addtitle><description>The influence of three newly developed bispyridinium antinicotinic compounds (the non‐oximes MB408, MB442 and MB444) on the therapeutic efficacy of a standard antidotal treatment (atropine in combination with an oxime) of acute poisoning by the organophosphorus nerve agents tabun and soman was studied in mice. The therapeutic efficacy of atropine in combination with an oxime with or without one of the bispyridinium non‐oximes was evaluated by determination of the LD50 values of the nerve agents and measurement of the survival time after supralethal poisoning. Addition of all the tested non‐oximes increased significantly the therapeutic efficacy of atropine in combination with an oxime against tabun poisoning. They also positively influenced the number of surviving mice 6 hr after supralethal poisoning with tabun. However, they were only slightly effective for the treatment of soman poisoning. The benefit of the tested bispyridinium non‐oximes was dose‐dependent. To conclude, the addition of bispyridinium non‐oximes to the standard antidotal treatment of acute poisoning with tabun was beneficial regardless of the chosen non‐oxime, but only slightly beneficial in the case of soman poisoning.</description><subject>Atropine</subject><subject>Biological &amp; chemical weapons</subject><subject>Effectiveness</subject><subject>Mice</subject><subject>Nerve agents</subject><subject>Oximes</subject><subject>Poisoning</subject><subject>Pyridinium</subject><subject>Reagents</subject><subject>Soman</subject><subject>Tabun</subject><issn>1742-7835</issn><issn>1742-7843</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp9Uc1u1DAYtBCIloULD4AscQHULf7L33F3uy2V2tLDco4c53PrKrGDnWyVWx-B9-FteJI6pPSIL-NvNJqRZhB6T8kxje9rpbr-mLKCJy_QIc0EW2a54C-f_zw5QG9CuCOEZYKS1-iAFZRmKU8O0e_tXjaD7I2z2Gnc3wI-t7oZwCqYiN2tB8BXcN-M-AT20LgOarw2oRu9qY01Q4tXtjd_Hn5Zo1wfGYU3ru3cYOuAP12uBcmPcATBZhCfccyagrZaGyXVOOVMHrXrZYN3HmTfgu0n-gr8HvDqZjqvnQnOGnuDjcWXRsFb9ErLJsC7J1ygH6fb3ebb8uL72flmdbFUPHaypEKLVHNVSEY4VLxIFYllUcF1VTNWVTljirIqlZlQvKpEkhaQFHmS5LnUueQL9HH27bz7OUDoyzs3eBsjS0Yoy5OcxJIX6MusUt6F4EGXnTet9GNJSTntVE47lX93iuIPT5ZD1UL9LP03TBTQWXBvGhj_Y1WuN9e72fQRA5Kdiw</recordid><startdate>201804</startdate><enddate>201804</enddate><creator>Kassa, Jiri</creator><creator>Timperley, Christopher M.</creator><creator>Bird, Mike</creator><creator>Williams, Rebecca L.</creator><creator>Green, A. Christopher</creator><creator>Tattersall, John E. H.</creator><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7TK</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>201804</creationdate><title>Evaluation of the Influence of Three Newly Developed Bispyridinium Anti‐nicotinic Compounds (MB408, MB442, MB444) on the Efficacy of Antidotal Treatment of Nerve Agent Poisoning in Mice</title><author>Kassa, Jiri ; Timperley, Christopher M. ; Bird, Mike ; Williams, Rebecca L. ; Green, A. Christopher ; Tattersall, John E. H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3935-14f46f3c9a203eb396c0293143fbd22bb822c12b6a74c3bb4569e5985588af8a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Atropine</topic><topic>Biological &amp; chemical weapons</topic><topic>Effectiveness</topic><topic>Mice</topic><topic>Nerve agents</topic><topic>Oximes</topic><topic>Poisoning</topic><topic>Pyridinium</topic><topic>Reagents</topic><topic>Soman</topic><topic>Tabun</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kassa, Jiri</creatorcontrib><creatorcontrib>Timperley, Christopher M.</creatorcontrib><creatorcontrib>Bird, Mike</creatorcontrib><creatorcontrib>Williams, Rebecca L.</creatorcontrib><creatorcontrib>Green, A. Christopher</creatorcontrib><creatorcontrib>Tattersall, John E. H.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium &amp; Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Basic &amp; clinical pharmacology &amp; toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kassa, Jiri</au><au>Timperley, Christopher M.</au><au>Bird, Mike</au><au>Williams, Rebecca L.</au><au>Green, A. Christopher</au><au>Tattersall, John E. H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of the Influence of Three Newly Developed Bispyridinium Anti‐nicotinic Compounds (MB408, MB442, MB444) on the Efficacy of Antidotal Treatment of Nerve Agent Poisoning in Mice</atitle><jtitle>Basic &amp; clinical pharmacology &amp; toxicology</jtitle><addtitle>Basic Clin Pharmacol Toxicol</addtitle><date>2018-04</date><risdate>2018</risdate><volume>122</volume><issue>4</issue><spage>429</spage><epage>435</epage><pages>429-435</pages><issn>1742-7835</issn><eissn>1742-7843</eissn><abstract>The influence of three newly developed bispyridinium antinicotinic compounds (the non‐oximes MB408, MB442 and MB444) on the therapeutic efficacy of a standard antidotal treatment (atropine in combination with an oxime) of acute poisoning by the organophosphorus nerve agents tabun and soman was studied in mice. The therapeutic efficacy of atropine in combination with an oxime with or without one of the bispyridinium non‐oximes was evaluated by determination of the LD50 values of the nerve agents and measurement of the survival time after supralethal poisoning. Addition of all the tested non‐oximes increased significantly the therapeutic efficacy of atropine in combination with an oxime against tabun poisoning. They also positively influenced the number of surviving mice 6 hr after supralethal poisoning with tabun. However, they were only slightly effective for the treatment of soman poisoning. The benefit of the tested bispyridinium non‐oximes was dose‐dependent. To conclude, the addition of bispyridinium non‐oximes to the standard antidotal treatment of acute poisoning with tabun was beneficial regardless of the chosen non‐oxime, but only slightly beneficial in the case of soman poisoning.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>29117635</pmid><doi>10.1111/bcpt.12935</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 1742-7835
ispartof Basic & clinical pharmacology & toxicology, 2018-04, Vol.122 (4), p.429-435
issn 1742-7835
1742-7843
language eng
recordid cdi_proquest_journals_2012858078
source Wiley Online Library Journals Frontfile Complete; Alma/SFX Local Collection
subjects Atropine
Biological & chemical weapons
Effectiveness
Mice
Nerve agents
Oximes
Poisoning
Pyridinium
Reagents
Soman
Tabun
title Evaluation of the Influence of Three Newly Developed Bispyridinium Anti‐nicotinic Compounds (MB408, MB442, MB444) on the Efficacy of Antidotal Treatment of Nerve Agent Poisoning in Mice
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-08T20%3A48%3A56IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Evaluation%20of%20the%20Influence%20of%20Three%20Newly%20Developed%20Bispyridinium%20Anti%E2%80%90nicotinic%20Compounds%20(MB408,%20MB442,%20MB444)%20on%20the%20Efficacy%20of%20Antidotal%20Treatment%20of%20Nerve%20Agent%20Poisoning%20in%20Mice&rft.jtitle=Basic%20&%20clinical%20pharmacology%20&%20toxicology&rft.au=Kassa,%20Jiri&rft.date=2018-04&rft.volume=122&rft.issue=4&rft.spage=429&rft.epage=435&rft.pages=429-435&rft.issn=1742-7835&rft.eissn=1742-7843&rft_id=info:doi/10.1111/bcpt.12935&rft_dat=%3Cproquest_cross%3E2012858078%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2012858078&rft_id=info:pmid/29117635&rfr_iscdi=true