Targeted Disruption of Nrf2 Causes Regenerative Immune-Mediated Hemolytic Anemia

A basic leucine zipper transcription factor, NF-E2-related factor 2 (Nrf2), plays a critical role in the cellular defense mechanism by mediating a coordinate up-regulation of antioxidant responsive element-driven detoxification and antioxidant genes. Here, we report that targeted disruption of Nrf2...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2004-06, Vol.101 (26), p.9751-9756
Hauptverfasser:	Lee, Jong-Min, Chan, Kaimin, Kan, Yuet Wai, Johnson, Jeffrey A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anemia Anemia, Hemolytic, Autoimmune - genetics Anemia, Hemolytic, Autoimmune - immunology Anemia, Hemolytic, Autoimmune - metabolism Anemia, Hemolytic, Autoimmune - pathology Animals Antibodies Antioxidants Antioxidants - metabolism Biological Sciences Blood plasma Cell Size - drug effects DNA-Binding Proteins - deficiency DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Erythrocytes Erythrocytes - drug effects Erythrocytes - immunology Erythrocytes - metabolism Erythrocytes - pathology Gene Deletion Gene Expression Regulation Genotype Hemolysis - drug effects Hemolytic anemia Hydrogen Peroxide - pharmacology Immunoglobulin G - immunology Immunology Knockout mice Mice Mice, Knockout NF-E2-Related Factor 2 Oxidative stress Oxidative Stress - drug effects Phenotype Response Elements - genetics Rodents Spleen Spleen - metabolism Spleen - pathology Splenomegaly - genetics Splenomegaly - pathology Tooth - physiology Trans-Activators - deficiency Trans-Activators - genetics Trans-Activators - metabolism
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