From Latent Disseminated Cells to Overt Metastasis: Genetic Analysis of Systemic Breast Cancer Progression

According to the present view, metastasis marks the end in a sequence of genomic changes underlying the progression of an epithelial cell to a lethal cancer. Here, we aimed to find out at what stage of tumor development transformed cells leave the primary tumor and whether a defined genotype corresp...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2003-06, Vol.100 (13), p.7737-7742
Hauptverfasser:	Schmidt-Kittler, Oleg, Ragg, Thomas, Daskalakis, Angela, Granzow, Martin, Ahr, Andre, Thomas J. F. Blankenstein, Kaufmann, Manfred, Diebold, Joachim, Arnholdt, Hans, Müller, Peter, Bischoff, Joachim, Harich, Detlev, Schlimok, Günter, Riethmüller, Gert, Eils, Roland, Klein, Christoph A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms Biological Sciences Bone Marrow - metabolism Breast cancer Breast Neoplasms - genetics Breast Neoplasms - pathology Cadherins - genetics Cancer Cells Chromosome Aberrations Chromosomes Chromosomes, Human, Pair 16 Comparative genomic hybridization Computational Biology Disease Progression Down-Regulation Epithelial cells Genetics Genome Genomics Genotype Humans In Situ Hybridization Loss of Heterozygosity Lymphatic Metastasis Metastasis Models, Genetic Neoplasm Metastasis Nucleic Acid Hybridization Phylogeny Protein-Tyrosine Kinases Retinoblastoma Protein - genetics Stem cells Time Factors Tumors Up-Regulation
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