Kinetics of Protein-Protein Association Explained by Brownian Dynamics Computer Simulation

Protein-protein bond formations, such as antibody-antigen complexation or aggregation of protein monomers into dimers and larger aggregates, occur with bimolecular rate constants on the order of 106M-1⋯-1, which is only 3 orders of magnitude slower than the diffusion-limited Smoluchowski rate. Howev...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1992-04, Vol.89 (8), p.3338-3342
Hauptverfasser:	Northrup, Scott H., Erickson, H. P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anions Biochemistry Biological and medical sciences Computer Simulation computer simulations Cytochromes Fundamental and applied biological sciences. Psychology Hydrogen bonds Interactions. Associations Intermolecular phenomena Kinetics mathematical models Mathematics Molecular biophysics Molecules Protein Binding Protein Conformation Proteins Proteins - chemistry Proteins - metabolism Retraining simulation Steering Trajectories
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