Antioxidant functionalized polymer capsules to prevent oxidative stress

[Display omitted] Polymeric capsules exhibit significant potential for therapeutic applications as microreactors, where the bio-chemical reactions of interest are efficiently performed in a spatial and time defined manner due to the encapsulation of an active biomolecule (e.g., enzyme) and control o...

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Veröffentlicht in:	Acta biomaterialia 2018-02, Vol.67, p.21-31
Hauptverfasser:	Larrañaga, Aitor, Isa, Isma Liza Mohd, Patil, Vaibhav, Thamboo, Sagana, Lomora, Mihai, Fernández-Yague, Marc A., Sarasua, Jose-Ramon, Palivan, Cornelia G., Pandit, Abhay
Format:	Artikel
Sprache:	eng
Schlagworte:	Active control ADAMTS5 Protein - metabolism Animals Antioxidants Antioxidants - pharmacology Calcium Calcium carbonate Capsules Catalase Catalase - metabolism Catalysts Cattle Cell Survival - drug effects Encapsulation Enzyme encapsulation Enzymes Free Radical Scavengers - pharmacology Free radicals Hydrogen peroxide Hydrogen Peroxide - toxicity Hydroxyl radicals Inflammatory diseases Intervertebral disc Layer-by-layer Matrix metalloproteinase Matrix Metalloproteinase 3 - metabolism Microreactors Nucleus Pulposus - drug effects Nucleus Pulposus - metabolism Nucleus Pulposus - pathology Oxidative stress Oxidative Stress - drug effects Polymer capsules Polymers Polymers - pharmacology Proteolysis Proteolytic enzymes Reagents Scavenging Stromelysin 1 Tannic acid Tannins - chemistry Therapeutic applications Thrombospondin
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