Persistent severe amiodarone-induced photosensitivity
Summary Amiodarone, a benzofuran derivative, has been used therapeutically as an antiarrhythmic and coronary vasodilator in Europe since 1964. One of its commoner side effects is cutaneous photosensitivity; more rarely, after ingestion of the drug for around 12 months, a slate‐grey or violaceous dis...
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| Veröffentlicht in: | Clinical and experimental dermatology 2005-09, Vol.30 (5), p.500-502 |
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| container_title | Clinical and experimental dermatology |
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| creator | Yones, S. S. O'Donoghue, N. B. Palmer, R. A. Menagé, H. du p. Hawk, J. L. M. |
| description | Summary
Amiodarone, a benzofuran derivative, has been used therapeutically as an antiarrhythmic and coronary vasodilator in Europe since 1964. One of its commoner side effects is cutaneous photosensitivity; more rarely, after ingestion of the drug for around 12 months, a slate‐grey or violaceous discoloration of sun‐exposed sites may gradually develop. Both of these side effects usually resolve within 2 years of discontinuation of the drug. We now present a woman who developed both photosensitivity and a slate‐grey discoloration whilst taking amiodarone; on discontinuation of the drug, the dyspigmentation gradually resolved, but the photosensitivity has persisted and the patient remains symptomatic more than 17 years later. |
| doi_str_mv | 10.1111/j.1365-2230.2005.01820.x |
| format | Article |
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Amiodarone, a benzofuran derivative, has been used therapeutically as an antiarrhythmic and coronary vasodilator in Europe since 1964. One of its commoner side effects is cutaneous photosensitivity; more rarely, after ingestion of the drug for around 12 months, a slate‐grey or violaceous discoloration of sun‐exposed sites may gradually develop. Both of these side effects usually resolve within 2 years of discontinuation of the drug. We now present a woman who developed both photosensitivity and a slate‐grey discoloration whilst taking amiodarone; on discontinuation of the drug, the dyspigmentation gradually resolved, but the photosensitivity has persisted and the patient remains symptomatic more than 17 years later.</description><identifier>ISSN: 0307-6938</identifier><identifier>EISSN: 1365-2230</identifier><identifier>DOI: 10.1111/j.1365-2230.2005.01820.x</identifier><identifier>PMID: 16045677</identifier><identifier>CODEN: CEDEDE</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Science Ltd</publisher><subject>Aged ; Amiodarone - adverse effects ; Anti-Arrhythmia Agents - adverse effects ; Biological and medical sciences ; Dermatology ; Facial Dermatoses - chemically induced ; Facial Dermatoses - pathology ; Female ; Humans ; Hyperpigmentation - chemically induced ; Hyperpigmentation - pathology ; Medical sciences ; Photosensitivity Disorders - chemically induced ; Photosensitivity Disorders - pathology ; Skin involvement in other diseases. Miscellaneous. General aspects</subject><ispartof>Clinical and experimental dermatology, 2005-09, Vol.30 (5), p.500-502</ispartof><rights>2005 INIST-CNRS</rights><rights>Copyright Blackwell Publishing Sep 2005</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4870-728303c76b75eeea7b0a08a1171af30383923481081af5775aa44e4f089a6c6f3</citedby><cites>FETCH-LOGICAL-c4870-728303c76b75eeea7b0a08a1171af30383923481081af5775aa44e4f089a6c6f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16956834$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16045677$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yones, S. S.</creatorcontrib><creatorcontrib>O'Donoghue, N. B.</creatorcontrib><creatorcontrib>Palmer, R. A.</creatorcontrib><creatorcontrib>Menagé, H. du p.</creatorcontrib><creatorcontrib>Hawk, J. L. M.</creatorcontrib><title>Persistent severe amiodarone-induced photosensitivity</title><title>Clinical and experimental dermatology</title><addtitle>Clin Exp Dermatol</addtitle><description>Summary
Amiodarone, a benzofuran derivative, has been used therapeutically as an antiarrhythmic and coronary vasodilator in Europe since 1964. One of its commoner side effects is cutaneous photosensitivity; more rarely, after ingestion of the drug for around 12 months, a slate‐grey or violaceous discoloration of sun‐exposed sites may gradually develop. Both of these side effects usually resolve within 2 years of discontinuation of the drug. We now present a woman who developed both photosensitivity and a slate‐grey discoloration whilst taking amiodarone; on discontinuation of the drug, the dyspigmentation gradually resolved, but the photosensitivity has persisted and the patient remains symptomatic more than 17 years later.</description><subject>Aged</subject><subject>Amiodarone - adverse effects</subject><subject>Anti-Arrhythmia Agents - adverse effects</subject><subject>Biological and medical sciences</subject><subject>Dermatology</subject><subject>Facial Dermatoses - chemically induced</subject><subject>Facial Dermatoses - pathology</subject><subject>Female</subject><subject>Humans</subject><subject>Hyperpigmentation - chemically induced</subject><subject>Hyperpigmentation - pathology</subject><subject>Medical sciences</subject><subject>Photosensitivity Disorders - chemically induced</subject><subject>Photosensitivity Disorders - pathology</subject><subject>Skin involvement in other diseases. Miscellaneous. 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M.</creator><general>Blackwell Science Ltd</general><general>Blackwell</general><general>Oxford University Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope></search><sort><creationdate>200509</creationdate><title>Persistent severe amiodarone-induced photosensitivity</title><author>Yones, S. S. ; O'Donoghue, N. B. ; Palmer, R. A. ; Menagé, H. du p. ; Hawk, J. L. M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4870-728303c76b75eeea7b0a08a1171af30383923481081af5775aa44e4f089a6c6f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Aged</topic><topic>Amiodarone - adverse effects</topic><topic>Anti-Arrhythmia Agents - adverse effects</topic><topic>Biological and medical sciences</topic><topic>Dermatology</topic><topic>Facial Dermatoses - chemically induced</topic><topic>Facial Dermatoses - pathology</topic><topic>Female</topic><topic>Humans</topic><topic>Hyperpigmentation - chemically induced</topic><topic>Hyperpigmentation - pathology</topic><topic>Medical sciences</topic><topic>Photosensitivity Disorders - chemically induced</topic><topic>Photosensitivity Disorders - pathology</topic><topic>Skin involvement in other diseases. Miscellaneous. General aspects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yones, S. S.</creatorcontrib><creatorcontrib>O'Donoghue, N. B.</creatorcontrib><creatorcontrib>Palmer, R. A.</creatorcontrib><creatorcontrib>Menagé, H. du p.</creatorcontrib><creatorcontrib>Hawk, J. L. M.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><jtitle>Clinical and experimental dermatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yones, S. S.</au><au>O'Donoghue, N. B.</au><au>Palmer, R. A.</au><au>Menagé, H. du p.</au><au>Hawk, J. L. M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Persistent severe amiodarone-induced photosensitivity</atitle><jtitle>Clinical and experimental dermatology</jtitle><addtitle>Clin Exp Dermatol</addtitle><date>2005-09</date><risdate>2005</risdate><volume>30</volume><issue>5</issue><spage>500</spage><epage>502</epage><pages>500-502</pages><issn>0307-6938</issn><eissn>1365-2230</eissn><coden>CEDEDE</coden><abstract>Summary
Amiodarone, a benzofuran derivative, has been used therapeutically as an antiarrhythmic and coronary vasodilator in Europe since 1964. One of its commoner side effects is cutaneous photosensitivity; more rarely, after ingestion of the drug for around 12 months, a slate‐grey or violaceous discoloration of sun‐exposed sites may gradually develop. Both of these side effects usually resolve within 2 years of discontinuation of the drug. We now present a woman who developed both photosensitivity and a slate‐grey discoloration whilst taking amiodarone; on discontinuation of the drug, the dyspigmentation gradually resolved, but the photosensitivity has persisted and the patient remains symptomatic more than 17 years later.</abstract><cop>Oxford, UK</cop><pub>Blackwell Science Ltd</pub><pmid>16045677</pmid><doi>10.1111/j.1365-2230.2005.01820.x</doi><tpages>3</tpages></addata></record> |
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| ispartof | Clinical and experimental dermatology, 2005-09, Vol.30 (5), p.500-502 |
| issn | 0307-6938 1365-2230 |
| language | eng |
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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current); Alma/SFX Local Collection |
| subjects | Aged Amiodarone - adverse effects Anti-Arrhythmia Agents - adverse effects Biological and medical sciences Dermatology Facial Dermatoses - chemically induced Facial Dermatoses - pathology Female Humans Hyperpigmentation - chemically induced Hyperpigmentation - pathology Medical sciences Photosensitivity Disorders - chemically induced Photosensitivity Disorders - pathology Skin involvement in other diseases. Miscellaneous. General aspects |
| title | Persistent severe amiodarone-induced photosensitivity |
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