Insulin receptor substrate 1 mediates insulin and insuilin-like growth factor I-stimulated maturation of Xenopus oocytes

Insulin receptor substrate 1 mediates insulin and insuilin-like growth factor I-stimulated maturation of Xenopus oocytes

Insulin and insulin-like growth factor I (IGF-I) initiate cellular functions by activating their homologous tyrosine kinase receptors. Research findings demonstrate that insulin receptor substrate-1 (IRS-1) serves a critical role in linking IGF-I and insulin to their final cellular responses.

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Veröffentlicht in:Proceedings of the National Academy of Sciences - PNAS 1993-06, Vol.90 (11), p.5172
Hauptverfasser: Chuang, Lee-Ming, Myers, Martin G, Seidner, Glen A, Birnbaum, Morris J
Format: Artikel
Sprache:eng
Schlagworte:
Cellular biology
Insulin
Medical research
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Zusammenfassung:Insulin and insulin-like growth factor I (IGF-I) initiate cellular functions by activating their homologous tyrosine kinase receptors. Research findings demonstrate that insulin receptor substrate-1 (IRS-1) serves a critical role in linking IGF-I and insulin to their final cellular responses.
ISSN:0027-8424
1091-6490