Mitochondrial Benzodiazepine Receptor Linked to Inner Membrane Ion Channels by Nanomolar Actions of Ligands
The mitochondrial benzodiazepine receptor (mBzR) binds a subset of benzodiazepines and isoquinoline carboxamides with nanomolar affinity and consists of the voltage-dependent anion channel, the adenine nucleotide translocator, and an 18-kDa protein. The effect of ligands of the mBzR on two inner mit...
Gespeichert in:
| Veröffentlicht in: | Proceedings of the National Academy of Sciences - PNAS 1993-02, Vol.90 (4), p.1374-1378 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1378 |
|---|---|
| container_issue | 4 |
| container_start_page | 1374 |
| container_title | Proceedings of the National Academy of Sciences - PNAS |
| container_volume | 90 |
| creator | Kinnally, Kathleen W. Zorov, Dmitry B. Antoneko, Yuri N. Snyder, Solomon H. McEnery, Maureen W. Tedeschi, Henry |
| description | The mitochondrial benzodiazepine receptor (mBzR) binds a subset of benzodiazepines and isoquinoline carboxamides with nanomolar affinity and consists of the voltage-dependent anion channel, the adenine nucleotide translocator, and an 18-kDa protein. The effect of ligands of the mBzR on two inner mitochondrial membrane channel activities was determined with patch-clamp techniques. The relative inhibitory potencies of the drugs resemble their binding affinities for the mBzR. Ro5-4864 and protoporphyrin IX inhibit activity of the multiple conductance channel (MCC) and the mitochondrial centum-picosiemen (mCtS) channel activities at nanomolar concentrations. PK11195 inhibits mCtS activity at similar levels. Higher concentrations of protoporphyrin IX induce MCC but possibly not mCtS activity. Clonazepam, which has low affinity for mBzR, is at least 500 times less potent at both channel activities. Ro15-1788, which also has a low mBzR affinity, inhibits MCC at very high concentrations (16 μ M). The findings indicate an association of these two channel activities with the proteins forming the mBzR complex and are consistent with an interaction of inner and outer membrane channels. |
| doi_str_mv | 10.1073/pnas.90.4.1374 |
| format | Article |
| fullrecord | <record><control><sourceid>jstor_proqu</sourceid><recordid>TN_cdi_proquest_journals_201248184</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><jstor_id>2361192</jstor_id><sourcerecordid>2361192</sourcerecordid><originalsourceid>FETCH-LOGICAL-c610t-37b6bb0f3edec17572cf69b2d53ec2e6e4af801865f762135e701c053a3d417d3</originalsourceid><addsrcrecordid>eNqFktuLEzEYxQdR1u7qq08KQRbfWnPPBHxZi5dCV0H0OWQy32zTnSY1mYq7f70ZWksVwadAzu98l5xU1TOCZwQr9nobbJ5pPOMzwhR_UE0I1mQqucYPqwnGVE1rTvnj6jznNcZYixqfVWdKKi2wmFS3136IbhVDm7zt0VsI97H19h62PgD6Ag62Q0xo6cMttGiIaBECJHQNmybZQixiQPOVLZd9Rs0d-mRD3MTeJnTlBh9DRrEr7hsb2vyketTZPsPTw3lRfXv_7uv843T5-cNifrWcOknwMGWqkU2DOwYtOKKEoq6TuqGtYOAoSOC2qzGppeiUpIQJUJg4LJhlLSeqZRfVm33d7a7ZQOsgDMn2Zpv8xqY7E603fyrBr8xN_GG4qJUo9lcHe4rfd5AHs_HZQd-XfeMuGyWEYkLy_4KkMIopXcCXf4HruEuhvIGhmFBek3qsNttDLsWcE3THgQk2Y9RmjNpobLgZoy6GF6drHvFDtkW_POg2O9t3JS_n8xHjUmtO5ckWY_nf6rGN6XZ9P8DP4aTfP8GiP9_r61y-zBGgTBKiKfsFY9TTvQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>201248184</pqid></control><display><type>article</type><title>Mitochondrial Benzodiazepine Receptor Linked to Inner Membrane Ion Channels by Nanomolar Actions of Ligands</title><source>PubMed (Medline)</source><source>Jstor Complete Legacy</source><source>MEDLINE</source><source>Full-Text Journals in Chemistry (Open access)</source><source>Alma/SFX Local Collection</source><creator>Kinnally, Kathleen W. ; Zorov, Dmitry B. ; Antoneko, Yuri N. ; Snyder, Solomon H. ; McEnery, Maureen W. ; Tedeschi, Henry</creator><creatorcontrib>Kinnally, Kathleen W. ; Zorov, Dmitry B. ; Antoneko, Yuri N. ; Snyder, Solomon H. ; McEnery, Maureen W. ; Tedeschi, Henry</creatorcontrib><description>The mitochondrial benzodiazepine receptor (mBzR) binds a subset of benzodiazepines and isoquinoline carboxamides with nanomolar affinity and consists of the voltage-dependent anion channel, the adenine nucleotide translocator, and an 18-kDa protein. The effect of ligands of the mBzR on two inner mitochondrial membrane channel activities was determined with patch-clamp techniques. The relative inhibitory potencies of the drugs resemble their binding affinities for the mBzR. Ro5-4864 and protoporphyrin IX inhibit activity of the multiple conductance channel (MCC) and the mitochondrial centum-picosiemen (mCtS) channel activities at nanomolar concentrations. PK11195 inhibits mCtS activity at similar levels. Higher concentrations of protoporphyrin IX induce MCC but possibly not mCtS activity. Clonazepam, which has low affinity for mBzR, is at least 500 times less potent at both channel activities. Ro15-1788, which also has a low mBzR affinity, inhibits MCC at very high concentrations (16 μ M). The findings indicate an association of these two channel activities with the proteins forming the mBzR complex and are consistent with an interaction of inner and outer membrane channels.</description><identifier>ISSN: 0027-8424</identifier><identifier>EISSN: 1091-6490</identifier><identifier>DOI: 10.1073/pnas.90.4.1374</identifier><identifier>PMID: 7679505</identifier><identifier>CODEN: PNASA6</identifier><language>eng</language><publisher>Washington, DC: National Academy of Sciences of the United States of America</publisher><subject>activity ; Animals ; benzodiazepine ; Benzodiazepines ; Benzodiazepinones - pharmacology ; Binding sites ; Biochemistry ; Biological and medical sciences ; Cell receptors ; Cell structures and functions ; centum-picosiemen channel ; Clonazepam - pharmacology ; Convulsants - pharmacology ; Electric potential ; Flumazenil - pharmacology ; Fundamental and applied biological sciences. Psychology ; Insect proteins ; interaction ; Intracellular Membranes - drug effects ; Intracellular Membranes - physiology ; Ion channels ; Ion Channels - drug effects ; Ion Channels - physiology ; Isoquinolines - pharmacology ; Ligands ; Male ; Membrane Potentials - drug effects ; Miscellaneous ; Mitochondria ; Mitochondria, Heart - drug effects ; Mitochondria, Heart - physiology ; Molecular and cellular biology ; multiple conductance channel ; Perfusion ; Protoporphyrins - pharmacology ; Rats ; Rats, Sprague-Dawley ; Receptors ; Receptors, GABA-A - drug effects ; Receptors, GABA-A - physiology ; Submitochondrial Particles - drug effects ; Submitochondrial Particles - physiology</subject><ispartof>Proceedings of the National Academy of Sciences - PNAS, 1993-02, Vol.90 (4), p.1374-1378</ispartof><rights>Copyright 1993 The National Academy of Sciences of the United States of America</rights><rights>1993 INIST-CNRS</rights><rights>Copyright National Academy of Sciences Feb 15, 1993</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c610t-37b6bb0f3edec17572cf69b2d53ec2e6e4af801865f762135e701c053a3d417d3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://www.pnas.org/content/90/4.cover.gif</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/2361192$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/2361192$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,723,776,780,799,881,27901,27902,53766,53768,57992,58225</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4699426$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7679505$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kinnally, Kathleen W.</creatorcontrib><creatorcontrib>Zorov, Dmitry B.</creatorcontrib><creatorcontrib>Antoneko, Yuri N.</creatorcontrib><creatorcontrib>Snyder, Solomon H.</creatorcontrib><creatorcontrib>McEnery, Maureen W.</creatorcontrib><creatorcontrib>Tedeschi, Henry</creatorcontrib><title>Mitochondrial Benzodiazepine Receptor Linked to Inner Membrane Ion Channels by Nanomolar Actions of Ligands</title><title>Proceedings of the National Academy of Sciences - PNAS</title><addtitle>Proc Natl Acad Sci U S A</addtitle><description>The mitochondrial benzodiazepine receptor (mBzR) binds a subset of benzodiazepines and isoquinoline carboxamides with nanomolar affinity and consists of the voltage-dependent anion channel, the adenine nucleotide translocator, and an 18-kDa protein. The effect of ligands of the mBzR on two inner mitochondrial membrane channel activities was determined with patch-clamp techniques. The relative inhibitory potencies of the drugs resemble their binding affinities for the mBzR. Ro5-4864 and protoporphyrin IX inhibit activity of the multiple conductance channel (MCC) and the mitochondrial centum-picosiemen (mCtS) channel activities at nanomolar concentrations. PK11195 inhibits mCtS activity at similar levels. Higher concentrations of protoporphyrin IX induce MCC but possibly not mCtS activity. Clonazepam, which has low affinity for mBzR, is at least 500 times less potent at both channel activities. Ro15-1788, which also has a low mBzR affinity, inhibits MCC at very high concentrations (16 μ M). The findings indicate an association of these two channel activities with the proteins forming the mBzR complex and are consistent with an interaction of inner and outer membrane channels.</description><subject>activity</subject><subject>Animals</subject><subject>benzodiazepine</subject><subject>Benzodiazepines</subject><subject>Benzodiazepinones - pharmacology</subject><subject>Binding sites</subject><subject>Biochemistry</subject><subject>Biological and medical sciences</subject><subject>Cell receptors</subject><subject>Cell structures and functions</subject><subject>centum-picosiemen channel</subject><subject>Clonazepam - pharmacology</subject><subject>Convulsants - pharmacology</subject><subject>Electric potential</subject><subject>Flumazenil - pharmacology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Insect proteins</subject><subject>interaction</subject><subject>Intracellular Membranes - drug effects</subject><subject>Intracellular Membranes - physiology</subject><subject>Ion channels</subject><subject>Ion Channels - drug effects</subject><subject>Ion Channels - physiology</subject><subject>Isoquinolines - pharmacology</subject><subject>Ligands</subject><subject>Male</subject><subject>Membrane Potentials - drug effects</subject><subject>Miscellaneous</subject><subject>Mitochondria</subject><subject>Mitochondria, Heart - drug effects</subject><subject>Mitochondria, Heart - physiology</subject><subject>Molecular and cellular biology</subject><subject>multiple conductance channel</subject><subject>Perfusion</subject><subject>Protoporphyrins - pharmacology</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Receptors</subject><subject>Receptors, GABA-A - drug effects</subject><subject>Receptors, GABA-A - physiology</subject><subject>Submitochondrial Particles - drug effects</subject><subject>Submitochondrial Particles - physiology</subject><issn>0027-8424</issn><issn>1091-6490</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFktuLEzEYxQdR1u7qq08KQRbfWnPPBHxZi5dCV0H0OWQy32zTnSY1mYq7f70ZWksVwadAzu98l5xU1TOCZwQr9nobbJ5pPOMzwhR_UE0I1mQqucYPqwnGVE1rTvnj6jznNcZYixqfVWdKKi2wmFS3136IbhVDm7zt0VsI97H19h62PgD6Ag62Q0xo6cMttGiIaBECJHQNmybZQixiQPOVLZd9Rs0d-mRD3MTeJnTlBh9DRrEr7hsb2vyketTZPsPTw3lRfXv_7uv843T5-cNifrWcOknwMGWqkU2DOwYtOKKEoq6TuqGtYOAoSOC2qzGppeiUpIQJUJg4LJhlLSeqZRfVm33d7a7ZQOsgDMn2Zpv8xqY7E603fyrBr8xN_GG4qJUo9lcHe4rfd5AHs_HZQd-XfeMuGyWEYkLy_4KkMIopXcCXf4HruEuhvIGhmFBek3qsNttDLsWcE3THgQk2Y9RmjNpobLgZoy6GF6drHvFDtkW_POg2O9t3JS_n8xHjUmtO5ckWY_nf6rGN6XZ9P8DP4aTfP8GiP9_r61y-zBGgTBKiKfsFY9TTvQ</recordid><startdate>19930215</startdate><enddate>19930215</enddate><creator>Kinnally, Kathleen W.</creator><creator>Zorov, Dmitry B.</creator><creator>Antoneko, Yuri N.</creator><creator>Snyder, Solomon H.</creator><creator>McEnery, Maureen W.</creator><creator>Tedeschi, Henry</creator><general>National Academy of Sciences of the United States of America</general><general>National Acad Sciences</general><general>National Academy of Sciences</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>M7Z</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19930215</creationdate><title>Mitochondrial Benzodiazepine Receptor Linked to Inner Membrane Ion Channels by Nanomolar Actions of Ligands</title><author>Kinnally, Kathleen W. ; Zorov, Dmitry B. ; Antoneko, Yuri N. ; Snyder, Solomon H. ; McEnery, Maureen W. ; Tedeschi, Henry</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c610t-37b6bb0f3edec17572cf69b2d53ec2e6e4af801865f762135e701c053a3d417d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>activity</topic><topic>Animals</topic><topic>benzodiazepine</topic><topic>Benzodiazepines</topic><topic>Benzodiazepinones - pharmacology</topic><topic>Binding sites</topic><topic>Biochemistry</topic><topic>Biological and medical sciences</topic><topic>Cell receptors</topic><topic>Cell structures and functions</topic><topic>centum-picosiemen channel</topic><topic>Clonazepam - pharmacology</topic><topic>Convulsants - pharmacology</topic><topic>Electric potential</topic><topic>Flumazenil - pharmacology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Insect proteins</topic><topic>interaction</topic><topic>Intracellular Membranes - drug effects</topic><topic>Intracellular Membranes - physiology</topic><topic>Ion channels</topic><topic>Ion Channels - drug effects</topic><topic>Ion Channels - physiology</topic><topic>Isoquinolines - pharmacology</topic><topic>Ligands</topic><topic>Male</topic><topic>Membrane Potentials - drug effects</topic><topic>Miscellaneous</topic><topic>Mitochondria</topic><topic>Mitochondria, Heart - drug effects</topic><topic>Mitochondria, Heart - physiology</topic><topic>Molecular and cellular biology</topic><topic>multiple conductance channel</topic><topic>Perfusion</topic><topic>Protoporphyrins - pharmacology</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Receptors</topic><topic>Receptors, GABA-A - drug effects</topic><topic>Receptors, GABA-A - physiology</topic><topic>Submitochondrial Particles - drug effects</topic><topic>Submitochondrial Particles - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kinnally, Kathleen W.</creatorcontrib><creatorcontrib>Zorov, Dmitry B.</creatorcontrib><creatorcontrib>Antoneko, Yuri N.</creatorcontrib><creatorcontrib>Snyder, Solomon H.</creatorcontrib><creatorcontrib>McEnery, Maureen W.</creatorcontrib><creatorcontrib>Tedeschi, Henry</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>Biochemistry Abstracts 1</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kinnally, Kathleen W.</au><au>Zorov, Dmitry B.</au><au>Antoneko, Yuri N.</au><au>Snyder, Solomon H.</au><au>McEnery, Maureen W.</au><au>Tedeschi, Henry</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mitochondrial Benzodiazepine Receptor Linked to Inner Membrane Ion Channels by Nanomolar Actions of Ligands</atitle><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle><addtitle>Proc Natl Acad Sci U S A</addtitle><date>1993-02-15</date><risdate>1993</risdate><volume>90</volume><issue>4</issue><spage>1374</spage><epage>1378</epage><pages>1374-1378</pages><issn>0027-8424</issn><eissn>1091-6490</eissn><coden>PNASA6</coden><abstract>The mitochondrial benzodiazepine receptor (mBzR) binds a subset of benzodiazepines and isoquinoline carboxamides with nanomolar affinity and consists of the voltage-dependent anion channel, the adenine nucleotide translocator, and an 18-kDa protein. The effect of ligands of the mBzR on two inner mitochondrial membrane channel activities was determined with patch-clamp techniques. The relative inhibitory potencies of the drugs resemble their binding affinities for the mBzR. Ro5-4864 and protoporphyrin IX inhibit activity of the multiple conductance channel (MCC) and the mitochondrial centum-picosiemen (mCtS) channel activities at nanomolar concentrations. PK11195 inhibits mCtS activity at similar levels. Higher concentrations of protoporphyrin IX induce MCC but possibly not mCtS activity. Clonazepam, which has low affinity for mBzR, is at least 500 times less potent at both channel activities. Ro15-1788, which also has a low mBzR affinity, inhibits MCC at very high concentrations (16 μ M). The findings indicate an association of these two channel activities with the proteins forming the mBzR complex and are consistent with an interaction of inner and outer membrane channels.</abstract><cop>Washington, DC</cop><pub>National Academy of Sciences of the United States of America</pub><pmid>7679505</pmid><doi>10.1073/pnas.90.4.1374</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0027-8424 |
| ispartof | Proceedings of the National Academy of Sciences - PNAS, 1993-02, Vol.90 (4), p.1374-1378 |
| issn | 0027-8424 1091-6490 |
| language | eng |
| recordid | cdi_proquest_journals_201248184 |
| source | PubMed (Medline); Jstor Complete Legacy; MEDLINE; Full-Text Journals in Chemistry (Open access); Alma/SFX Local Collection |
| subjects | activity Animals benzodiazepine Benzodiazepines Benzodiazepinones - pharmacology Binding sites Biochemistry Biological and medical sciences Cell receptors Cell structures and functions centum-picosiemen channel Clonazepam - pharmacology Convulsants - pharmacology Electric potential Flumazenil - pharmacology Fundamental and applied biological sciences. Psychology Insect proteins interaction Intracellular Membranes - drug effects Intracellular Membranes - physiology Ion channels Ion Channels - drug effects Ion Channels - physiology Isoquinolines - pharmacology Ligands Male Membrane Potentials - drug effects Miscellaneous Mitochondria Mitochondria, Heart - drug effects Mitochondria, Heart - physiology Molecular and cellular biology multiple conductance channel Perfusion Protoporphyrins - pharmacology Rats Rats, Sprague-Dawley Receptors Receptors, GABA-A - drug effects Receptors, GABA-A - physiology Submitochondrial Particles - drug effects Submitochondrial Particles - physiology |
| title | Mitochondrial Benzodiazepine Receptor Linked to Inner Membrane Ion Channels by Nanomolar Actions of Ligands |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-11T18%3A26%3A32IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-jstor_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Mitochondrial%20Benzodiazepine%20Receptor%20Linked%20to%20Inner%20Membrane%20Ion%20Channels%20by%20Nanomolar%20Actions%20of%20Ligands&rft.jtitle=Proceedings%20of%20the%20National%20Academy%20of%20Sciences%20-%20PNAS&rft.au=Kinnally,%20Kathleen%20W.&rft.date=1993-02-15&rft.volume=90&rft.issue=4&rft.spage=1374&rft.epage=1378&rft.pages=1374-1378&rft.issn=0027-8424&rft.eissn=1091-6490&rft.coden=PNASA6&rft_id=info:doi/10.1073/pnas.90.4.1374&rft_dat=%3Cjstor_proqu%3E2361192%3C/jstor_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=201248184&rft_id=info:pmid/7679505&rft_jstor_id=2361192&rfr_iscdi=true |