Molecular Dissection of Subunit Interfaces in the Acetylcholine Receptor: Identification of Residues that Determine Curare Selectivity

The acetylcholine receptor from vertebrate skeletal muscle is a transmembrane channel that binds nerve-released acetylcholine to elicit rapid transport of small cations. Composed of two α subunits and one β, one γ, and one δ subunit, the receptor is a cooperative protein containing two sites that bi...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1993-10, Vol.90 (20), p.9436-9440
1. Verfasser:	Sine, Steven M.
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 cells Agonists Animals Base Sequence Binding Sites Biological and medical sciences Cell lines Cell receptors Cell structures and functions Chimeras Cholinergic receptors Complementary DNA Curare - pharmacology Fundamental and applied biological sciences. Psychology HEK293 cells Humans Ligands Macromolecular Substances Molecular and cellular biology Molecular Sequence Data Monoamines receptors (catecholamine, serotonine, histamine, acetylcholine) Oligodeoxyribonucleotides - chemistry Oligonucleotides Pharmacology Point Mutation Protein Binding Protein Conformation Receptors, Nicotinic - chemistry Receptors, Nicotinic - drug effects Receptors, Nicotinic - metabolism Recombinant Fusion Proteins Sequence Alignment Sequence Homology, Amino Acid Structure-Activity Relationship Tubocurarine - analogs & derivatives Tubocurarine - metabolism
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