Deposition of mannose-binding lectin and ficolins and activation of the lectin pathway of complement on the surface of polyurethane tubing used for cardiopulmonary bypass
The artificial surface used for cardiopulmonary bypass (CPB) is a crucial factor activating the complement system and thus contributing to the generation of a systemic inflammatory response. The activation of classical and alternative pathways on this artificial surface is well known. In contrast, l...
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| Veröffentlicht in: | Journal of biomedical materials research. Part B, Applied biomaterials Applied biomaterials, 2018-04, Vol.106 (3), p.1202-1208 |
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| creator | Eppa, Łukasz Pągowska-Klimek, Izabela Świerzko, Anna S Moll, Maciej Krajewski, Wojciech R Cedzyński, Maciej |
| description | The artificial surface used for cardiopulmonary bypass (CPB) is a crucial factor activating the complement system and thus contributing to the generation of a systemic inflammatory response. The activation of classical and alternative pathways on this artificial surface is well known. In contrast, lectin pathway (LP) activation has not been fully investigated, although noted during CPB in several studies. Moreover, we have recently proved the contribution of the LP to the generation of the systemic inflammatory response syndrome after pediatric cardiac surgery. The aim of this study was to assess LP-mediated complement activation on the surface of polyurethane CPB circuit tubing (noncoated Chalice
), used for CPB procedures in children with congenital heart disease. We found deposition of mannose-binding lectin, ficolin-1, -2, and -3 on the surface of unused tubing and on tubing used for CPB from a small minority of patients. Furthermore, we observed deposition of complement C4 activation products on tubing used for CPB and previously unused tubing after incubation with normal serum. The latter finding indicates LP activation in vitro on the polyurethane surface. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 1202-1208, 2018. |
| doi_str_mv | 10.1002/jbm.b.33933 |
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), used for CPB procedures in children with congenital heart disease. We found deposition of mannose-binding lectin, ficolin-1, -2, and -3 on the surface of unused tubing and on tubing used for CPB from a small minority of patients. Furthermore, we observed deposition of complement C4 activation products on tubing used for CPB and previously unused tubing after incubation with normal serum. The latter finding indicates LP activation in vitro on the polyurethane surface. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 1202-1208, 2018.</description><identifier>ISSN: 1552-4973</identifier><identifier>EISSN: 1552-4981</identifier><identifier>DOI: 10.1002/jbm.b.33933</identifier><identifier>PMID: 28561998</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Adolescent ; Binding ; Biomedical materials ; Blood Vessel Prosthesis ; Cardiopulmonary Bypass ; Child ; Child, Preschool ; Children ; Complement ; Complement activation ; Complement Activation - drug effects ; Complement C4 ; Complement component C4 ; Coronary artery disease ; Deposition ; Female ; Ficolins ; Heart ; Heart Defects, Congenital - surgery ; Heart diseases ; Heart surgery ; Humans ; Incubation ; Infant ; Inflammation ; Inflammatory response ; Lectins ; Lectins - chemistry ; Lectins - pharmacokinetics ; Male ; Mannose ; Mannose-Binding Lectin - chemistry ; Mannose-Binding Lectin - pharmacokinetics ; Materials research ; Materials science ; Polyurethane ; Polyurethane resins ; Polyurethanes - chemistry ; Surgery ; Systemic inflammatory response syndrome</subject><ispartof>Journal of biomedical materials research. Part B, Applied biomaterials, 2018-04, Vol.106 (3), p.1202-1208</ispartof><rights>2017 Wiley Periodicals, Inc.</rights><rights>2018 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c317t-2a6a86761fdbc51f7b47995a04946488a86558793a02fbaf1daaa22c1a7f47603</citedby><cites>FETCH-LOGICAL-c317t-2a6a86761fdbc51f7b47995a04946488a86558793a02fbaf1daaa22c1a7f47603</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28561998$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Eppa, Łukasz</creatorcontrib><creatorcontrib>Pągowska-Klimek, Izabela</creatorcontrib><creatorcontrib>Świerzko, Anna S</creatorcontrib><creatorcontrib>Moll, Maciej</creatorcontrib><creatorcontrib>Krajewski, Wojciech R</creatorcontrib><creatorcontrib>Cedzyński, Maciej</creatorcontrib><title>Deposition of mannose-binding lectin and ficolins and activation of the lectin pathway of complement on the surface of polyurethane tubing used for cardiopulmonary bypass</title><title>Journal of biomedical materials research. Part B, Applied biomaterials</title><addtitle>J Biomed Mater Res B Appl Biomater</addtitle><description>The artificial surface used for cardiopulmonary bypass (CPB) is a crucial factor activating the complement system and thus contributing to the generation of a systemic inflammatory response. The activation of classical and alternative pathways on this artificial surface is well known. In contrast, lectin pathway (LP) activation has not been fully investigated, although noted during CPB in several studies. Moreover, we have recently proved the contribution of the LP to the generation of the systemic inflammatory response syndrome after pediatric cardiac surgery. The aim of this study was to assess LP-mediated complement activation on the surface of polyurethane CPB circuit tubing (noncoated Chalice
), used for CPB procedures in children with congenital heart disease. We found deposition of mannose-binding lectin, ficolin-1, -2, and -3 on the surface of unused tubing and on tubing used for CPB from a small minority of patients. Furthermore, we observed deposition of complement C4 activation products on tubing used for CPB and previously unused tubing after incubation with normal serum. The latter finding indicates LP activation in vitro on the polyurethane surface. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 1202-1208, 2018.</description><subject>Adolescent</subject><subject>Binding</subject><subject>Biomedical materials</subject><subject>Blood Vessel Prosthesis</subject><subject>Cardiopulmonary Bypass</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Children</subject><subject>Complement</subject><subject>Complement activation</subject><subject>Complement Activation - drug effects</subject><subject>Complement C4</subject><subject>Complement component C4</subject><subject>Coronary artery disease</subject><subject>Deposition</subject><subject>Female</subject><subject>Ficolins</subject><subject>Heart</subject><subject>Heart Defects, Congenital - surgery</subject><subject>Heart diseases</subject><subject>Heart surgery</subject><subject>Humans</subject><subject>Incubation</subject><subject>Infant</subject><subject>Inflammation</subject><subject>Inflammatory response</subject><subject>Lectins</subject><subject>Lectins - chemistry</subject><subject>Lectins - pharmacokinetics</subject><subject>Male</subject><subject>Mannose</subject><subject>Mannose-Binding Lectin - chemistry</subject><subject>Mannose-Binding Lectin - pharmacokinetics</subject><subject>Materials research</subject><subject>Materials science</subject><subject>Polyurethane</subject><subject>Polyurethane resins</subject><subject>Polyurethanes - chemistry</subject><subject>Surgery</subject><subject>Systemic inflammatory response syndrome</subject><issn>1552-4973</issn><issn>1552-4981</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kclO5DAQhq0Ro2GZOXFHljiiNF6y-YjYJSQuM-eo7Ni0W4kdbAfUr8RTjkPTnGr7qv6SfoROKVlRQtjlRo4rueJccP4DHdGqYkUpWnrwnTf8EB3HuMlwTSr-Cx2ytqqpEO0R-rjRk482We-wN3gE53zUhbSut-4FD1ol6zC4Hhur_GBd_Cwgt99gv5XWek9OkNbvsF26yo_ToEftEs7YwsQ5GFB6GU5-2M5BpzU4jdMsF7E56izjA1YQeuuneRi9g7DFcjtBjL_RTwND1H--4gn6d3f79_qheHq-f7y-eioUp00qGNTQ1k1NTS9VRU0jy0aICkgpyrps2zysqrYRHAgzEgztAYAxRaExZVMTfoLOd3en4F9nHVO38XNwWbJjhLKSCF62mbrYUSr4GIM23RTsmL_tKOkWX7rsSye7T18yffZ1c5aj7r_ZvRH8P5xSjQY</recordid><startdate>201804</startdate><enddate>201804</enddate><creator>Eppa, Łukasz</creator><creator>Pągowska-Klimek, Izabela</creator><creator>Świerzko, Anna S</creator><creator>Moll, Maciej</creator><creator>Krajewski, Wojciech R</creator><creator>Cedzyński, Maciej</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QO</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7T7</scope><scope>7TA</scope><scope>7TB</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>C1K</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>JG9</scope><scope>JQ2</scope><scope>K9.</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>P64</scope></search><sort><creationdate>201804</creationdate><title>Deposition of mannose-binding lectin and ficolins and activation of the lectin pathway of complement on the surface of polyurethane tubing used for cardiopulmonary bypass</title><author>Eppa, Łukasz ; 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Part B, Applied biomaterials</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Eppa, Łukasz</au><au>Pągowska-Klimek, Izabela</au><au>Świerzko, Anna S</au><au>Moll, Maciej</au><au>Krajewski, Wojciech R</au><au>Cedzyński, Maciej</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Deposition of mannose-binding lectin and ficolins and activation of the lectin pathway of complement on the surface of polyurethane tubing used for cardiopulmonary bypass</atitle><jtitle>Journal of biomedical materials research. Part B, Applied biomaterials</jtitle><addtitle>J Biomed Mater Res B Appl Biomater</addtitle><date>2018-04</date><risdate>2018</risdate><volume>106</volume><issue>3</issue><spage>1202</spage><epage>1208</epage><pages>1202-1208</pages><issn>1552-4973</issn><eissn>1552-4981</eissn><abstract>The artificial surface used for cardiopulmonary bypass (CPB) is a crucial factor activating the complement system and thus contributing to the generation of a systemic inflammatory response. The activation of classical and alternative pathways on this artificial surface is well known. In contrast, lectin pathway (LP) activation has not been fully investigated, although noted during CPB in several studies. Moreover, we have recently proved the contribution of the LP to the generation of the systemic inflammatory response syndrome after pediatric cardiac surgery. The aim of this study was to assess LP-mediated complement activation on the surface of polyurethane CPB circuit tubing (noncoated Chalice
), used for CPB procedures in children with congenital heart disease. We found deposition of mannose-binding lectin, ficolin-1, -2, and -3 on the surface of unused tubing and on tubing used for CPB from a small minority of patients. Furthermore, we observed deposition of complement C4 activation products on tubing used for CPB and previously unused tubing after incubation with normal serum. The latter finding indicates LP activation in vitro on the polyurethane surface. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 1202-1208, 2018.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>28561998</pmid><doi>10.1002/jbm.b.33933</doi><tpages>7</tpages></addata></record> |
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| subjects | Adolescent Binding Biomedical materials Blood Vessel Prosthesis Cardiopulmonary Bypass Child Child, Preschool Children Complement Complement activation Complement Activation - drug effects Complement C4 Complement component C4 Coronary artery disease Deposition Female Ficolins Heart Heart Defects, Congenital - surgery Heart diseases Heart surgery Humans Incubation Infant Inflammation Inflammatory response Lectins Lectins - chemistry Lectins - pharmacokinetics Male Mannose Mannose-Binding Lectin - chemistry Mannose-Binding Lectin - pharmacokinetics Materials research Materials science Polyurethane Polyurethane resins Polyurethanes - chemistry Surgery Systemic inflammatory response syndrome |
| title | Deposition of mannose-binding lectin and ficolins and activation of the lectin pathway of complement on the surface of polyurethane tubing used for cardiopulmonary bypass |
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