Identification and Analysis of the Gene Encoding Human PC2, a Prohormone Convertase Expressed in Neuroendocrine Tissues

In recent studies we have identified PC2 and PC3, members of a family of serine proteases that are related structurally to subtilisin, and have provided evidence that these are involved in the tissue-specific processing of prohormones and neuropeptides. PC2 is expressed at high levels in the islets...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1992-06, Vol.89 (11), p.4977-4981
Hauptverfasser:	Ohagi, Shinya, LaMendola, Joseph, LeBeau, Michelle M., Espinosa, Rafael, Takeda, Jun, Smeekens, Steven P., Chan, Shu Jin, Steiner, Donald F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Base Sequence Biological and medical sciences Chromosomes Chromosomes, Human, Pair 20 Cloning, Molecular Complementary DNA Deoxyribonucleic acid DNA Endocrine system Exons Fundamental and applied biological sciences. Psychology Genes Genes. Genome Genetics Hep G2 cells Hormones Humans Introns Islets of Langerhans Messenger RNA Molecular and cellular biology Molecular genetics Molecular Sequence Data Plasmids Promoter regions Promoter Regions, Genetic Proprotein Convertase 2 Protein Precursors - metabolism Restriction Mapping Sequence Alignment Serine Endopeptidases - genetics
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