Specific Prolongation of Allograft Survival by a T-Cell-Receptor-Derived Peptide
Allograft rejection results from the specific recognition by host CD8+T cells of allogeneic major histocompatibility complex (MHC) molecules on the tissue graft. The specificity of this cellular response is determined by the molecular interaction of the T-cell receptor (TCR) on host T cells with the...
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| Veröffentlicht in: | Proceedings of the National Academy of Sciences - PNAS 1993-11, Vol.90 (21), p.9872-9876 |
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| container_title | Proceedings of the National Academy of Sciences - PNAS |
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| creator | Goss, John A. Alexander-Miller, Martha A. Gorka, John Flye, M. Wayne Connolly, Janet M. Hansen, Ted H. |
| description | Allograft rejection results from the specific recognition by host CD8+T cells of allogeneic major histocompatibility complex (MHC) molecules on the tissue graft. The specificity of this cellular response is determined by the molecular interaction of the T-cell receptor (TCR) on host T cells with the MHC molecule and its bound ligand on the grafted tissue. To better understand the precise manner by which the TCR interacts with the MHC-peptide complex and how to therapeutically intervene, we have studied the allogeneic response to the mouse class I MHC molecule Ld. In this report, the therapeutic potential of a synthetic peptide derived from the TCR V β8 variable region that predominates in responses to Ldwas tested. This V β8-derived peptide was found to dramatically and specifically block the in vivo and in vitro allogeneic response to Ld. Furthermore, this specific blocking is not dependent upon the presence of V β8+effector cells nor does the Vβ8 peptide bind to the Ldligand binding cleft. We propose that this peptide functions as an antagonist, competing with the native TCR for recognition of the Ldmolecule. |
| doi_str_mv | 10.1073/pnas.90.21.9872 |
| format | Article |
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Wayne ; Connolly, Janet M. ; Hansen, Ted H.</creator><creatorcontrib>Goss, John A. ; Alexander-Miller, Martha A. ; Gorka, John ; Flye, M. Wayne ; Connolly, Janet M. ; Hansen, Ted H.</creatorcontrib><description>Allograft rejection results from the specific recognition by host CD8+T cells of allogeneic major histocompatibility complex (MHC) molecules on the tissue graft. The specificity of this cellular response is determined by the molecular interaction of the T-cell receptor (TCR) on host T cells with the MHC molecule and its bound ligand on the grafted tissue. To better understand the precise manner by which the TCR interacts with the MHC-peptide complex and how to therapeutically intervene, we have studied the allogeneic response to the mouse class I MHC molecule Ld. In this report, the therapeutic potential of a synthetic peptide derived from the TCR V β8 variable region that predominates in responses to Ldwas tested. This V β8-derived peptide was found to dramatically and specifically block the in vivo and in vitro allogeneic response to Ld. Furthermore, this specific blocking is not dependent upon the presence of V β8+effector cells nor does the Vβ8 peptide bind to the Ldligand binding cleft. We propose that this peptide functions as an antagonist, competing with the native TCR for recognition of the Ldmolecule.</description><identifier>ISSN: 0027-8424</identifier><identifier>EISSN: 1091-6490</identifier><identifier>DOI: 10.1073/pnas.90.21.9872</identifier><identifier>PMID: 8234328</identifier><identifier>CODEN: PNASA6</identifier><language>eng</language><publisher>Washington, DC: National Academy of Sciences of the United States of America</publisher><subject>Amino Acid Sequence ; Animals ; Biological and medical sciences ; Cell Line ; Cell lines ; Female ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; Graft rejection ; Graft Survival - drug effects ; Graft Survival - immunology ; Haplotypes ; Histocompatibility Antigens Class I - immunology ; Histocompatibility Antigens Class II - immunology ; Homologous transplantation ; Immune response ; Immunity (Disease) ; Ligands ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Mice, Inbred Strains ; Molecular Sequence Data ; Molecules ; Peptide Fragments - pharmacology ; Receptors, Antigen, T-Cell - immunology ; Rodents ; Skin Transplantation - immunology ; T cell antigen receptors ; T lymphocytes ; T-Lymphocytes, Cytotoxic - immunology ; Tissue, organ and graft immunology ; Transplantation, Homologous - immunology ; Transponders</subject><ispartof>Proceedings of the National Academy of Sciences - PNAS, 1993-11, Vol.90 (21), p.9872-9876</ispartof><rights>Copyright 1993 The National Academy of Sciences of the United States of America</rights><rights>1994 INIST-CNRS</rights><rights>Copyright National Academy of Sciences Nov 1, 1993</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c578t-7764ea9a6002f50aa4cd0a7c78809d97f5113d7957f46b406f3d29cf4fb2b5253</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://www.pnas.org/content/90/21.cover.gif</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/2363363$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/2363363$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,309,310,314,727,780,784,789,790,803,885,23930,23931,25140,27924,27925,53791,53793,58017,58250</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3817862$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8234328$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Goss, John A.</creatorcontrib><creatorcontrib>Alexander-Miller, Martha A.</creatorcontrib><creatorcontrib>Gorka, John</creatorcontrib><creatorcontrib>Flye, M. Wayne</creatorcontrib><creatorcontrib>Connolly, Janet M.</creatorcontrib><creatorcontrib>Hansen, Ted H.</creatorcontrib><title>Specific Prolongation of Allograft Survival by a T-Cell-Receptor-Derived Peptide</title><title>Proceedings of the National Academy of Sciences - PNAS</title><addtitle>Proc Natl Acad Sci U S A</addtitle><description>Allograft rejection results from the specific recognition by host CD8+T cells of allogeneic major histocompatibility complex (MHC) molecules on the tissue graft. The specificity of this cellular response is determined by the molecular interaction of the T-cell receptor (TCR) on host T cells with the MHC molecule and its bound ligand on the grafted tissue. To better understand the precise manner by which the TCR interacts with the MHC-peptide complex and how to therapeutically intervene, we have studied the allogeneic response to the mouse class I MHC molecule Ld. In this report, the therapeutic potential of a synthetic peptide derived from the TCR V β8 variable region that predominates in responses to Ldwas tested. This V β8-derived peptide was found to dramatically and specifically block the in vivo and in vitro allogeneic response to Ld. Furthermore, this specific blocking is not dependent upon the presence of V β8+effector cells nor does the Vβ8 peptide bind to the Ldligand binding cleft. We propose that this peptide functions as an antagonist, competing with the native TCR for recognition of the Ldmolecule.</description><subject>Amino Acid Sequence</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cell Line</subject><subject>Cell lines</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>Graft rejection</subject><subject>Graft Survival - drug effects</subject><subject>Graft Survival - immunology</subject><subject>Haplotypes</subject><subject>Histocompatibility Antigens Class I - immunology</subject><subject>Histocompatibility Antigens Class II - immunology</subject><subject>Homologous transplantation</subject><subject>Immune response</subject><subject>Immunity (Disease)</subject><subject>Ligands</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Mice, Inbred C57BL</subject><subject>Mice, Inbred Strains</subject><subject>Molecular Sequence Data</subject><subject>Molecules</subject><subject>Peptide Fragments - pharmacology</subject><subject>Receptors, Antigen, T-Cell - immunology</subject><subject>Rodents</subject><subject>Skin Transplantation - immunology</subject><subject>T cell antigen receptors</subject><subject>T lymphocytes</subject><subject>T-Lymphocytes, Cytotoxic - immunology</subject><subject>Tissue, organ and graft immunology</subject><subject>Transplantation, Homologous - immunology</subject><subject>Transponders</subject><issn>0027-8424</issn><issn>1091-6490</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUuLFDEUhYMoYzu6dqNSiOiqepJUnuBmaJ8wYOOM65BOJW2adKVMqhrn35uiy_axUAiEcL5777k5ADxGcIkgby76TuelhEuMllJwfAcsEJSoZkTCu2ABIea1IJjcBw9y3kEIJRXwDJwJ3JAGiwVYX_fWeOdNtU4xxG6rBx-7KrrqMoS4TdoN1fWYDv6gQ7W5rXR1U69sCPVna2w_xFS_sckfbFuty9O39iG453TI9tF8n4Mv797erD7UV5_ef1xdXtWGcjHUnDNitdSsWHQUak1MCzU3XAgoW8kdRahpuaTcEbYhkLmmxdI44jZ4QzFtzsHrY99-3Oxta2w3JB1Un_xep1sVtVd_Kp3_qrbxoAhnnJTyl3N5it9Gmwe199mUxXRn45gVZ5Ch4u2_IGKcQiYn8Plf4C6OqSt_oDBEuKFUoAJdHCGTYs7JupNhBNUUqJoCVRIqjNQUaKl4-vueJ35OsOgvZl1no4NLujM-n7BGIC7Y1ObVjE39f6q_5ig3hjDY70Mhn_2TLMCTI7DLJf8TgRvWTOcHzk3J9A</recordid><startdate>19931101</startdate><enddate>19931101</enddate><creator>Goss, John A.</creator><creator>Alexander-Miller, Martha A.</creator><creator>Gorka, John</creator><creator>Flye, M. 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Psychology</topic><topic>Fundamental immunology</topic><topic>Graft rejection</topic><topic>Graft Survival - drug effects</topic><topic>Graft Survival - immunology</topic><topic>Haplotypes</topic><topic>Histocompatibility Antigens Class I - immunology</topic><topic>Histocompatibility Antigens Class II - immunology</topic><topic>Homologous transplantation</topic><topic>Immune response</topic><topic>Immunity (Disease)</topic><topic>Ligands</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Mice, Inbred C57BL</topic><topic>Mice, Inbred Strains</topic><topic>Molecular Sequence Data</topic><topic>Molecules</topic><topic>Peptide Fragments - pharmacology</topic><topic>Receptors, Antigen, T-Cell - immunology</topic><topic>Rodents</topic><topic>Skin Transplantation - immunology</topic><topic>T cell antigen receptors</topic><topic>T lymphocytes</topic><topic>T-Lymphocytes, Cytotoxic - immunology</topic><topic>Tissue, organ and graft immunology</topic><topic>Transplantation, Homologous - immunology</topic><topic>Transponders</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Goss, John A.</creatorcontrib><creatorcontrib>Alexander-Miller, Martha A.</creatorcontrib><creatorcontrib>Gorka, John</creatorcontrib><creatorcontrib>Flye, M. 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Wayne</au><au>Connolly, Janet M.</au><au>Hansen, Ted H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Specific Prolongation of Allograft Survival by a T-Cell-Receptor-Derived Peptide</atitle><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle><addtitle>Proc Natl Acad Sci U S A</addtitle><date>1993-11-01</date><risdate>1993</risdate><volume>90</volume><issue>21</issue><spage>9872</spage><epage>9876</epage><pages>9872-9876</pages><issn>0027-8424</issn><eissn>1091-6490</eissn><coden>PNASA6</coden><abstract>Allograft rejection results from the specific recognition by host CD8+T cells of allogeneic major histocompatibility complex (MHC) molecules on the tissue graft. The specificity of this cellular response is determined by the molecular interaction of the T-cell receptor (TCR) on host T cells with the MHC molecule and its bound ligand on the grafted tissue. To better understand the precise manner by which the TCR interacts with the MHC-peptide complex and how to therapeutically intervene, we have studied the allogeneic response to the mouse class I MHC molecule Ld. In this report, the therapeutic potential of a synthetic peptide derived from the TCR V β8 variable region that predominates in responses to Ldwas tested. This V β8-derived peptide was found to dramatically and specifically block the in vivo and in vitro allogeneic response to Ld. Furthermore, this specific blocking is not dependent upon the presence of V β8+effector cells nor does the Vβ8 peptide bind to the Ldligand binding cleft. We propose that this peptide functions as an antagonist, competing with the native TCR for recognition of the Ldmolecule.</abstract><cop>Washington, DC</cop><pub>National Academy of Sciences of the United States of America</pub><pmid>8234328</pmid><doi>10.1073/pnas.90.21.9872</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Proceedings of the National Academy of Sciences - PNAS, 1993-11, Vol.90 (21), p.9872-9876 |
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| source | MEDLINE; JSTOR Archive Collection A-Z Listing; PubMed Central; Alma/SFX Local Collection; Free Full-Text Journals in Chemistry |
| subjects | Amino Acid Sequence Animals Biological and medical sciences Cell Line Cell lines Female Fundamental and applied biological sciences. Psychology Fundamental immunology Graft rejection Graft Survival - drug effects Graft Survival - immunology Haplotypes Histocompatibility Antigens Class I - immunology Histocompatibility Antigens Class II - immunology Homologous transplantation Immune response Immunity (Disease) Ligands Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Inbred Strains Molecular Sequence Data Molecules Peptide Fragments - pharmacology Receptors, Antigen, T-Cell - immunology Rodents Skin Transplantation - immunology T cell antigen receptors T lymphocytes T-Lymphocytes, Cytotoxic - immunology Tissue, organ and graft immunology Transplantation, Homologous - immunology Transponders |
| title | Specific Prolongation of Allograft Survival by a T-Cell-Receptor-Derived Peptide |
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