Stable Growth Transformation of Human T Lymphocytes by Herpesvirus saimiri
Herpesvirus saimiri induces T-cell lymphomas in various species of New World monkeys and in rabbits, and it is able to immortalize monkey T lymphocytes in vitro. Sequences responsible for these effects have been localized to a region of the genome that varies significantly among the virus subgroups...
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| Veröffentlicht in: | Proceedings of the National Academy of Sciences - PNAS 1992-04, Vol.89 (7), p.3116-3119 |
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| container_title | Proceedings of the National Academy of Sciences - PNAS |
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| creator | Biesinger, Brigitte Muller-Fleckenstein, Ingrid Simmer, Birgit Lang, Gerlinde Wittmann, Sabine Platzer, Erich Desrosiers, Ronald C. Fleckenstein, Bernhard |
| description | Herpesvirus saimiri induces T-cell lymphomas in various species of New World monkeys and in rabbits, and it is able to immortalize monkey T lymphocytes in vitro. Sequences responsible for these effects have been localized to a region of the genome that varies significantly among the virus subgroups A, B, and C. We now report that infection of human blood lymphocytes and thymocytes with strains of subgroup C, in contrast to viruses of the other subgroups, yields continuously proliferating T-cell lines with the phenotype of mature CD4- or CD8-positive cells. Infection with strains of Herpesvirus saimiri subgroup C can thus be used to generate human T-cell lines for a variety of immunological and developmental studies. |
| doi_str_mv | 10.1073/pnas.89.7.3116 |
| format | Article |
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Sequences responsible for these effects have been localized to a region of the genome that varies significantly among the virus subgroups A, B, and C. We now report that infection of human blood lymphocytes and thymocytes with strains of subgroup C, in contrast to viruses of the other subgroups, yields continuously proliferating T-cell lines with the phenotype of mature CD4- or CD8-positive cells. Infection with strains of Herpesvirus saimiri subgroup C can thus be used to generate human T-cell lines for a variety of immunological and developmental studies.</description><identifier>ISSN: 0027-8424</identifier><identifier>EISSN: 1091-6490</identifier><identifier>DOI: 10.1073/pnas.89.7.3116</identifier><identifier>PMID: 1313581</identifier><language>eng</language><publisher>United States: National Academy of Sciences of the United States of America</publisher><subject>Antigens, Differentiation, T-Lymphocyte - analysis ; Blood ; Blood cells ; Cell Division ; Cell lines ; Cell Transformation, Viral ; Cellular biology ; DNA, Viral - analysis ; Flow Cytometry ; Herpes viruses ; Herpesvirus 2, Saimiriine ; Herpesvirus saimiri ; Humans ; Immunity (Disease) ; In Vitro Techniques ; K562 cells ; Kidney cells ; Leukocytes ; Lymphocytes ; Medical research ; Saimiriine herpesvirus 2 ; T lymphocytes ; T-Lymphocytes - cytology ; T-Lymphocytes - immunology ; T-Lymphocytes - microbiology ; Viruses</subject><ispartof>Proceedings of the National Academy of Sciences - PNAS, 1992-04, Vol.89 (7), p.3116-3119</ispartof><rights>Copyright 1992 The National Academy of Sciences of the United States of America</rights><rights>Copyright National Academy of Sciences Apr 1, 1992</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4306-3d4f6a33ebc4e77dd9d380195496d93cd25ff853dfac63c81cfa61d18da37de03</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://www.pnas.org/content/89/7.cover.gif</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/2359045$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/2359045$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,723,776,780,799,881,27903,27904,53769,53771,57995,58228</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1313581$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Biesinger, Brigitte</creatorcontrib><creatorcontrib>Muller-Fleckenstein, Ingrid</creatorcontrib><creatorcontrib>Simmer, Birgit</creatorcontrib><creatorcontrib>Lang, Gerlinde</creatorcontrib><creatorcontrib>Wittmann, Sabine</creatorcontrib><creatorcontrib>Platzer, Erich</creatorcontrib><creatorcontrib>Desrosiers, Ronald C.</creatorcontrib><creatorcontrib>Fleckenstein, Bernhard</creatorcontrib><title>Stable Growth Transformation of Human T Lymphocytes by Herpesvirus saimiri</title><title>Proceedings of the National Academy of Sciences - PNAS</title><addtitle>Proc Natl Acad Sci U S A</addtitle><description>Herpesvirus saimiri induces T-cell lymphomas in various species of New World monkeys and in rabbits, and it is able to immortalize monkey T lymphocytes in vitro. Sequences responsible for these effects have been localized to a region of the genome that varies significantly among the virus subgroups A, B, and C. We now report that infection of human blood lymphocytes and thymocytes with strains of subgroup C, in contrast to viruses of the other subgroups, yields continuously proliferating T-cell lines with the phenotype of mature CD4- or CD8-positive cells. Infection with strains of Herpesvirus saimiri subgroup C can thus be used to generate human T-cell lines for a variety of immunological and developmental studies.</description><subject>Antigens, Differentiation, T-Lymphocyte - analysis</subject><subject>Blood</subject><subject>Blood cells</subject><subject>Cell Division</subject><subject>Cell lines</subject><subject>Cell Transformation, Viral</subject><subject>Cellular biology</subject><subject>DNA, Viral - analysis</subject><subject>Flow Cytometry</subject><subject>Herpes viruses</subject><subject>Herpesvirus 2, Saimiriine</subject><subject>Herpesvirus saimiri</subject><subject>Humans</subject><subject>Immunity (Disease)</subject><subject>In Vitro Techniques</subject><subject>K562 cells</subject><subject>Kidney cells</subject><subject>Leukocytes</subject><subject>Lymphocytes</subject><subject>Medical research</subject><subject>Saimiriine herpesvirus 2</subject><subject>T lymphocytes</subject><subject>T-Lymphocytes - cytology</subject><subject>T-Lymphocytes - immunology</subject><subject>T-Lymphocytes - microbiology</subject><subject>Viruses</subject><issn>0027-8424</issn><issn>1091-6490</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkTuP1DAUhS0EWoaFlgoki2K7BL8S2xINWsEOaCQKhtry-MF4lMTBdhbm35NolmWggOoW5ztX594DwHOMaow4fT0OOtdC1rymGLcPwAojiauWSfQQrBAivBKMsMfgSc4HhJBsBLoAF5hi2gi8Ah8_F73rHLxJ8XvZw23SQ_Yx9bqEOMDo4Xrq9QC3cHPsx300x-Iy3B3h2qXR5duQpgyzDn1I4Sl45HWX3bO7eQm-vH-3vV5Xm083H67fbirDKGoraplvNaVuZ5jj3FppqUBYNky2VlJjSeO9aKj12rTUCGy8brHFwmrKrUP0Erw57R2nXe-scUNJulNjCr1ORxV1UH8qQ9irr_FWMSFwM9uv7uwpfptcLqoP2biu04OLU1aciDnO_J__gbjFVBLEZvDVX-AhTmmYf6AIwoRwhpbU9QkyKeacnL8PjJFamlRLk0pIxdXS5Gx4eX7mb_xU3Zm--H6p5_6rf-nKT11X3I8ygy9O4CGXmO5JQhuJWEN_Aq2Ku_U</recordid><startdate>19920401</startdate><enddate>19920401</enddate><creator>Biesinger, Brigitte</creator><creator>Muller-Fleckenstein, Ingrid</creator><creator>Simmer, Birgit</creator><creator>Lang, Gerlinde</creator><creator>Wittmann, Sabine</creator><creator>Platzer, Erich</creator><creator>Desrosiers, Ronald C.</creator><creator>Fleckenstein, Bernhard</creator><general>National Academy of Sciences of the United States of America</general><general>National Acad Sciences</general><general>National Academy of Sciences</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19920401</creationdate><title>Stable Growth Transformation of Human T Lymphocytes by Herpesvirus saimiri</title><author>Biesinger, Brigitte ; 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| ispartof | Proceedings of the National Academy of Sciences - PNAS, 1992-04, Vol.89 (7), p.3116-3119 |
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| language | eng |
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| source | Jstor Complete Legacy; MEDLINE; PubMed Central; Alma/SFX Local Collection; Free Full-Text Journals in Chemistry |
| subjects | Antigens, Differentiation, T-Lymphocyte - analysis Blood Blood cells Cell Division Cell lines Cell Transformation, Viral Cellular biology DNA, Viral - analysis Flow Cytometry Herpes viruses Herpesvirus 2, Saimiriine Herpesvirus saimiri Humans Immunity (Disease) In Vitro Techniques K562 cells Kidney cells Leukocytes Lymphocytes Medical research Saimiriine herpesvirus 2 T lymphocytes T-Lymphocytes - cytology T-Lymphocytes - immunology T-Lymphocytes - microbiology Viruses |
| title | Stable Growth Transformation of Human T Lymphocytes by Herpesvirus saimiri |
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