DKK2 imparts tumor immunity evasion through [beta]-catenin-independent suppression of cytotoxic immune-cell activation

Immunotherapy offers new options for cancer treatment, but efficacy varies across cancer types. Colorectal cancers (CRCs) are largely refractory to immune-checkpoint blockade, which suggests the presence of yet uncharacterized immune-suppressive mechanisms. Here we report that the loss of adenomatos...

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Veröffentlicht in:	Nature medicine 2018-03, Vol.24 (3), p.262
Hauptverfasser:	Xiao, Qian, Wu, Jibo, Wang, Wei-Jia, Chen, Shiyang, Zheng, Yingxia, Yu, Xiaoqing, Meeth, Katrina, Sahraei, Mahnaz, Bothwell, Alfred L M, Chen, Lieping, Bosenberg, Marcus, Chen, Jianfeng, Sexl, Veronika, Sun, Le, Li, Lin, Tang, Wenwen, Wu, Dianqing
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenomatous polyposis coli Antigen-presenting cells Cancer Care and treatment CD8 antigen Cell activation Cellular proteins Cellular signal transduction Colorectal cancer Cytotoxicity Development and progression Genetic aspects Health aspects Immune checkpoint Immune response Immunity Immunity (Disease) Immunotherapy Intestine Localization LRP5 protein Lymphocytes Lymphocytes T Melanoma Natural killer cells PD-1 protein Polyposis Polyposis coli PTEN protein Signaling Stat5 protein Tumor cells Tumor suppressor genes Tumors Wnt protein β-Catenin
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