Genome-free Viral Capsids as Carriers for Positron Emission Tomography Radiolabels

Purpose We have developed a modular synthetic strategy to append imaging agents to a viral capsid. Procedures The hollow protein shell of bacteriophage MS2 (mtMS2) was labeled on its inside surface with [ 18 F]fluorobenzaldehyde through a multistep bioconjugation strategy. An aldehyde functional gro...

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Veröffentlicht in:	Molecular imaging and biology 2008-07, Vol.10 (4), p.182-191
Hauptverfasser:	M. Hooker, Jacob, P. O’Neil, James, W. Romanini, Dante, E. Taylor, Scott, Francis, Matthew B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Benzaldehydes - chemical synthesis Benzaldehydes - chemistry Capsid - chemistry Capsid Proteins - blood Capsid Proteins - chemical synthesis Capsid Proteins - chemistry Capsid Proteins - isolation & purification Capsid Proteins - metabolism Capsid Proteins - pharmacokinetics Coumarins - chemistry Dogs Drug Delivery Systems Fluorine Radioisotopes - chemistry Imaging Isotope Labeling Levivirus - chemistry Medicine Medicine & Public Health Molecular Structure Molecular Weight Oximes - chemistry Positron-Emission Tomography - methods Radiology Radiopharmaceuticals - chemistry Rats Rats, Sprague-Dawley Research Article
Online-Zugang:	Volltext
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