Serine- and threonine-derived diamine equivalents for site-specific incorporation of platinum centers in peptides, and the anticancer potential of these conjugates

A modular strategy that allows introduction of one or more reactive platinum units at chosen locations along a peptide sequence is presented. This makes use of diazides generated from serine and threonine as diamine equivalents which can be conjugated to the peptide under standard coupling condition...

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Veröffentlicht in:	New journal of chemistry 2018, Vol.42 (4), p.2450-2458
Hauptverfasser:	Kumbhakonam, Sateeshkumar, Vellaisamy, Kasipandi, Saroj, Soumya, Venkatesan, Nalini, D., Karunagaran, Kannoth Manheri, Muraleedharan
Format:	Artikel
Sprache:	eng
Schlagworte:	Anticancer properties Cancer Conjugates Deoxyribonucleic acid DNA Equivalence Lysine Peptides Platinum Toxicity
Online-Zugang:	Volltext
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