Impact of Endothelial 18-kDa Translocator Protein on the Quantification of ^sup 18^F-DPA-714

18F-DPA-714 is a second-generation tracer for PET imaging of the 18-kDa translocator protein (TSPO), a marker of neuroinflammation. Analysis and interpretation of TSPO PET are challenging, especially because of the basal expression of TSPO. The aim of this study was to evaluate a compartmental model...

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Veröffentlicht in:	The Journal of nuclear medicine (1978) 2018-02, Vol.59 (2), p.307
Hauptverfasser:	Wimberley, Catriona, Lavisse, Sonia, Brulon, Vincent, Peyronneau, Marie-Anne, Leroy, Claire, Bodini, Benedetta, Remy, Philippe, Stankoff, Bruno, Buvat, Irène, Bottlaender, Michel
Format:	Artikel
Sprache:	eng
Schlagworte:	Affinity Analysis Binders Binding Brain Correlation DNA probes Endothelial cells Endothelium Fluorine isotopes Gene expression Inflammation Mathematical models Medical imaging Neuroimaging Neurological disorders Parameter estimation Parameters Positron emission Positron emission tomography Probes Proteins Ribonucleic acid RNA Tomography
Online-Zugang:	Volltext
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