Capsinoids activate brown adipose tissue (BAT) with increased energy expenditure associated with subthreshold 18-fluorine fluorodeoxyglucose uptake in BAT-positive humans confirmed by positron emission tomography scan
ABSTRACT Background Capsinoids are reported to increase energy expenditure (EE) via brown adipose tissue (BAT) stimulation. However, imaging of BAT activation by capsinoids remains limited. Because BAT activation is a potential therapeutic strategy for obesity and related metabolic disorders, we sou...
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| Veröffentlicht in: | The American journal of clinical nutrition 2018-01, Vol.107 (1), p.62-70 |
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| creator | Sun, Lijuan Camps, Stefan G Goh, Hui Jen Govindharajulu, Priya Schaefferkoetter, Joshua D Townsend, David W Verma, Sanjay K Velan, S Sendhil Sun, Lei Sze, Siu Kwan Lim, Su Chi Boehm, Bernhard Otto Henry, Christiani Jeyakumar Leow, Melvin Khee-Shing |
| description | ABSTRACT
Background
Capsinoids are reported to increase energy expenditure (EE) via brown adipose tissue (BAT) stimulation. However, imaging of BAT activation by capsinoids remains limited. Because BAT activation is a potential therapeutic strategy for obesity and related metabolic disorders, we sought to prove that capsinoid-induced BAT activation can be visualized by 18-fluorine fluorodeoxyglucose (18F-FDG) positron emission tomography (PET).
Objective
We compared capsinoids and cold exposure on BAT activation and whole-body EE.
Design
Twenty healthy participants (8 men, 12 women) with a mean age of 26 y (range: 21–35 y) and a body mass index (kg/m2) of 21.7 (range: 18.5–26.0) underwent 18F-FDG PET and whole-body calorimetry after ingestion of 12 mg capsinoids or ≤2 h of cold exposure (∼14.5°C) in a crossover design. Mean standardized uptake values (SUVs) of the region of interest and BAT volumes were calculated. Blood metabolites were measured before and 2 h after each treatment.
Results
All of the participants showed negligible 18F-FDG uptake post-capsinoid ingestion. Upon cold exposure, 12 participants showed avid 18F-FDG uptake into supraclavicular and lateral neck adipose tissues (BAT-positive group), whereas the remaining 8 participants (BAT-negative group) showed undetectable uptake. Capsinoids and cold exposure increased EE, although cold induced a 2-fold increase in whole-body EE and higher fat oxidation, insulin sensitivity, and HDL cholesterol compared with capsinoids.
Conclusions
Capsinoids only increased EE in BAT-positive participants, which suggests that BAT mediates EE evoked by capsinoids. This implies that capsinoids stimulate BAT to a lesser degree than cold exposure as evidenced by 18F-FDG uptake below the presently accepted SUV thresholds defining BAT activation. This trial was registered at www.clinicaltrials.gov as NCT02964442. |
| doi_str_mv | 10.1093/ajcn/nqx025 |
| format | Article |
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Background
Capsinoids are reported to increase energy expenditure (EE) via brown adipose tissue (BAT) stimulation. However, imaging of BAT activation by capsinoids remains limited. Because BAT activation is a potential therapeutic strategy for obesity and related metabolic disorders, we sought to prove that capsinoid-induced BAT activation can be visualized by 18-fluorine fluorodeoxyglucose (18F-FDG) positron emission tomography (PET).
Objective
We compared capsinoids and cold exposure on BAT activation and whole-body EE.
Design
Twenty healthy participants (8 men, 12 women) with a mean age of 26 y (range: 21–35 y) and a body mass index (kg/m2) of 21.7 (range: 18.5–26.0) underwent 18F-FDG PET and whole-body calorimetry after ingestion of 12 mg capsinoids or ≤2 h of cold exposure (∼14.5°C) in a crossover design. Mean standardized uptake values (SUVs) of the region of interest and BAT volumes were calculated. Blood metabolites were measured before and 2 h after each treatment.
Results
All of the participants showed negligible 18F-FDG uptake post-capsinoid ingestion. Upon cold exposure, 12 participants showed avid 18F-FDG uptake into supraclavicular and lateral neck adipose tissues (BAT-positive group), whereas the remaining 8 participants (BAT-negative group) showed undetectable uptake. Capsinoids and cold exposure increased EE, although cold induced a 2-fold increase in whole-body EE and higher fat oxidation, insulin sensitivity, and HDL cholesterol compared with capsinoids.
Conclusions
Capsinoids only increased EE in BAT-positive participants, which suggests that BAT mediates EE evoked by capsinoids. This implies that capsinoids stimulate BAT to a lesser degree than cold exposure as evidenced by 18F-FDG uptake below the presently accepted SUV thresholds defining BAT activation. This trial was registered at www.clinicaltrials.gov as NCT02964442.</description><identifier>ISSN: 0002-9165</identifier><identifier>EISSN: 1938-3207</identifier><identifier>DOI: 10.1093/ajcn/nqx025</identifier><identifier>PMID: 29381803</identifier><language>eng</language><publisher>United States: Oxford University Press</publisher><subject>Activation ; Adipose tissue ; Adipose tissue (brown) ; Adipose Tissue, Brown - drug effects ; Adipose Tissue, Brown - metabolism ; Adiposity ; Adult ; Body Mass Index ; Body size ; Calorimetry ; Calorimetry, Indirect ; Capsicum - chemistry ; Cholesterol ; Clavicle ; Cold Temperature ; Cross-Over Studies ; Design standards ; Energy ; Energy expenditure ; Energy Metabolism ; Exposure ; Female ; Fluorine ; Fluorine isotopes ; Fluorodeoxyglucose F18 - administration & dosage ; Fluorodeoxyglucose F18 - pharmacokinetics ; High density lipoprotein ; Humans ; Image processing ; Ingestion ; Insulin ; Male ; Metabolic disorders ; Metabolites ; Neck ; NMR ; Non-Randomized Controlled Trials as Topic ; Nuclear magnetic resonance ; Obesity ; Oxidation ; Plant Extracts - administration & dosage ; Positron emission ; Positron emission tomography ; Tissues ; Tomography ; Young Adult</subject><ispartof>The American journal of clinical nutrition, 2018-01, Vol.107 (1), p.62-70</ispartof><rights>2018 American Society for Nutrition. All rights reserved. 2018</rights><rights>2018 American Society for Nutrition. All rights reserved.</rights><rights>Copyright American Society for Clinical Nutrition, Inc. Jan 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c411t-dbb524a3f4f23ffcdb539d86a20dcbcf6d1ecb5f681e452d886c87c755dfc7a23</citedby><cites>FETCH-LOGICAL-c411t-dbb524a3f4f23ffcdb539d86a20dcbcf6d1ecb5f681e452d886c87c755dfc7a23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29381803$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sun, Lijuan</creatorcontrib><creatorcontrib>Camps, Stefan G</creatorcontrib><creatorcontrib>Goh, Hui Jen</creatorcontrib><creatorcontrib>Govindharajulu, Priya</creatorcontrib><creatorcontrib>Schaefferkoetter, Joshua D</creatorcontrib><creatorcontrib>Townsend, David W</creatorcontrib><creatorcontrib>Verma, Sanjay K</creatorcontrib><creatorcontrib>Velan, S Sendhil</creatorcontrib><creatorcontrib>Sun, Lei</creatorcontrib><creatorcontrib>Sze, Siu Kwan</creatorcontrib><creatorcontrib>Lim, Su Chi</creatorcontrib><creatorcontrib>Boehm, Bernhard Otto</creatorcontrib><creatorcontrib>Henry, Christiani Jeyakumar</creatorcontrib><creatorcontrib>Leow, Melvin Khee-Shing</creatorcontrib><title>Capsinoids activate brown adipose tissue (BAT) with increased energy expenditure associated with subthreshold 18-fluorine fluorodeoxyglucose uptake in BAT-positive humans confirmed by positron emission tomography scan</title><title>The American journal of clinical nutrition</title><addtitle>Am J Clin Nutr</addtitle><description>ABSTRACT
Background
Capsinoids are reported to increase energy expenditure (EE) via brown adipose tissue (BAT) stimulation. However, imaging of BAT activation by capsinoids remains limited. Because BAT activation is a potential therapeutic strategy for obesity and related metabolic disorders, we sought to prove that capsinoid-induced BAT activation can be visualized by 18-fluorine fluorodeoxyglucose (18F-FDG) positron emission tomography (PET).
Objective
We compared capsinoids and cold exposure on BAT activation and whole-body EE.
Design
Twenty healthy participants (8 men, 12 women) with a mean age of 26 y (range: 21–35 y) and a body mass index (kg/m2) of 21.7 (range: 18.5–26.0) underwent 18F-FDG PET and whole-body calorimetry after ingestion of 12 mg capsinoids or ≤2 h of cold exposure (∼14.5°C) in a crossover design. Mean standardized uptake values (SUVs) of the region of interest and BAT volumes were calculated. Blood metabolites were measured before and 2 h after each treatment.
Results
All of the participants showed negligible 18F-FDG uptake post-capsinoid ingestion. Upon cold exposure, 12 participants showed avid 18F-FDG uptake into supraclavicular and lateral neck adipose tissues (BAT-positive group), whereas the remaining 8 participants (BAT-negative group) showed undetectable uptake. Capsinoids and cold exposure increased EE, although cold induced a 2-fold increase in whole-body EE and higher fat oxidation, insulin sensitivity, and HDL cholesterol compared with capsinoids.
Conclusions
Capsinoids only increased EE in BAT-positive participants, which suggests that BAT mediates EE evoked by capsinoids. This implies that capsinoids stimulate BAT to a lesser degree than cold exposure as evidenced by 18F-FDG uptake below the presently accepted SUV thresholds defining BAT activation. This trial was registered at www.clinicaltrials.gov as NCT02964442.</description><subject>Activation</subject><subject>Adipose tissue</subject><subject>Adipose tissue (brown)</subject><subject>Adipose Tissue, Brown - drug effects</subject><subject>Adipose Tissue, Brown - metabolism</subject><subject>Adiposity</subject><subject>Adult</subject><subject>Body Mass Index</subject><subject>Body size</subject><subject>Calorimetry</subject><subject>Calorimetry, Indirect</subject><subject>Capsicum - chemistry</subject><subject>Cholesterol</subject><subject>Clavicle</subject><subject>Cold Temperature</subject><subject>Cross-Over Studies</subject><subject>Design standards</subject><subject>Energy</subject><subject>Energy expenditure</subject><subject>Energy Metabolism</subject><subject>Exposure</subject><subject>Female</subject><subject>Fluorine</subject><subject>Fluorine isotopes</subject><subject>Fluorodeoxyglucose F18 - administration & dosage</subject><subject>Fluorodeoxyglucose F18 - pharmacokinetics</subject><subject>High density lipoprotein</subject><subject>Humans</subject><subject>Image processing</subject><subject>Ingestion</subject><subject>Insulin</subject><subject>Male</subject><subject>Metabolic disorders</subject><subject>Metabolites</subject><subject>Neck</subject><subject>NMR</subject><subject>Non-Randomized Controlled Trials as Topic</subject><subject>Nuclear magnetic resonance</subject><subject>Obesity</subject><subject>Oxidation</subject><subject>Plant Extracts - administration & dosage</subject><subject>Positron emission</subject><subject>Positron emission tomography</subject><subject>Tissues</subject><subject>Tomography</subject><subject>Young Adult</subject><issn>0002-9165</issn><issn>1938-3207</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kV1rFDEUhoModlu98l4CglRkbJL5yl7WRW2h0Jt6PWSSk52sO8k0H3bnp_pvzHZqL73KgTw87zm8CL2j5Asl6_JC7KS9sPcHwuoXaEXXJS9KRtqXaEUIYcWaNvUJOg1hRwhlFW9eoxOWIcpJuUJ_NmIKxjqjAhYymt8iAu69e7BYKDO5ADiaEBLg86-Xd5_wg4kDNlZ6EAEUBgt-O2M4TGCVickDFiE4abJGLXBIfRw8hMHtFaa80PvkvLGAHwenwB3m7T7JY1SaovgF2Y9zWJHTTd4I8JBGYQOWzmrjxyzuZ_z46Z3FMOb9TB6iG93Wi2mYcZDCvkGvtNgHePv0nqGf37_dba6Km9sf15vLm0JWlMZC9X3NKlHqSrNSa6n6ulwr3ghGlOylbhQF2de64RSqminOG8lb2da10rIVrDxDHxbv5N19ghC7nUve5siOEdI2LSVlk6nPCyW9C8GD7iZvRuHnjpLuWGN3rLFbasz0-ydn6vO9z-y_3jLwcQFcmv5r-gvaga75</recordid><startdate>20180101</startdate><enddate>20180101</enddate><creator>Sun, Lijuan</creator><creator>Camps, Stefan G</creator><creator>Goh, Hui Jen</creator><creator>Govindharajulu, Priya</creator><creator>Schaefferkoetter, Joshua D</creator><creator>Townsend, David W</creator><creator>Verma, Sanjay K</creator><creator>Velan, S Sendhil</creator><creator>Sun, Lei</creator><creator>Sze, Siu Kwan</creator><creator>Lim, Su Chi</creator><creator>Boehm, Bernhard Otto</creator><creator>Henry, Christiani Jeyakumar</creator><creator>Leow, Melvin Khee-Shing</creator><general>Oxford University Press</general><general>American Society for Clinical Nutrition, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7T7</scope><scope>7TS</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>P64</scope></search><sort><creationdate>20180101</creationdate><title>Capsinoids activate brown adipose tissue (BAT) with increased energy expenditure associated with subthreshold 18-fluorine fluorodeoxyglucose uptake in BAT-positive humans confirmed by positron emission tomography scan</title><author>Sun, Lijuan ; Camps, Stefan G ; Goh, Hui Jen ; Govindharajulu, Priya ; Schaefferkoetter, Joshua D ; Townsend, David W ; Verma, Sanjay K ; Velan, S Sendhil ; Sun, Lei ; Sze, Siu Kwan ; Lim, Su Chi ; Boehm, Bernhard Otto ; Henry, Christiani Jeyakumar ; Leow, Melvin Khee-Shing</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c411t-dbb524a3f4f23ffcdb539d86a20dcbcf6d1ecb5f681e452d886c87c755dfc7a23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Activation</topic><topic>Adipose tissue</topic><topic>Adipose tissue (brown)</topic><topic>Adipose Tissue, Brown - drug effects</topic><topic>Adipose Tissue, Brown - metabolism</topic><topic>Adiposity</topic><topic>Adult</topic><topic>Body Mass Index</topic><topic>Body size</topic><topic>Calorimetry</topic><topic>Calorimetry, Indirect</topic><topic>Capsicum - chemistry</topic><topic>Cholesterol</topic><topic>Clavicle</topic><topic>Cold Temperature</topic><topic>Cross-Over Studies</topic><topic>Design standards</topic><topic>Energy</topic><topic>Energy expenditure</topic><topic>Energy Metabolism</topic><topic>Exposure</topic><topic>Female</topic><topic>Fluorine</topic><topic>Fluorine isotopes</topic><topic>Fluorodeoxyglucose F18 - administration & dosage</topic><topic>Fluorodeoxyglucose F18 - pharmacokinetics</topic><topic>High density lipoprotein</topic><topic>Humans</topic><topic>Image processing</topic><topic>Ingestion</topic><topic>Insulin</topic><topic>Male</topic><topic>Metabolic disorders</topic><topic>Metabolites</topic><topic>Neck</topic><topic>NMR</topic><topic>Non-Randomized Controlled Trials as Topic</topic><topic>Nuclear magnetic resonance</topic><topic>Obesity</topic><topic>Oxidation</topic><topic>Plant Extracts - administration & dosage</topic><topic>Positron emission</topic><topic>Positron emission tomography</topic><topic>Tissues</topic><topic>Tomography</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sun, Lijuan</creatorcontrib><creatorcontrib>Camps, Stefan G</creatorcontrib><creatorcontrib>Goh, Hui Jen</creatorcontrib><creatorcontrib>Govindharajulu, Priya</creatorcontrib><creatorcontrib>Schaefferkoetter, Joshua D</creatorcontrib><creatorcontrib>Townsend, David W</creatorcontrib><creatorcontrib>Verma, Sanjay K</creatorcontrib><creatorcontrib>Velan, S Sendhil</creatorcontrib><creatorcontrib>Sun, Lei</creatorcontrib><creatorcontrib>Sze, Siu Kwan</creatorcontrib><creatorcontrib>Lim, Su Chi</creatorcontrib><creatorcontrib>Boehm, Bernhard Otto</creatorcontrib><creatorcontrib>Henry, Christiani Jeyakumar</creatorcontrib><creatorcontrib>Leow, Melvin Khee-Shing</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Physical Education Index</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>The American journal of clinical nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sun, Lijuan</au><au>Camps, Stefan G</au><au>Goh, Hui Jen</au><au>Govindharajulu, Priya</au><au>Schaefferkoetter, Joshua D</au><au>Townsend, David W</au><au>Verma, Sanjay K</au><au>Velan, S Sendhil</au><au>Sun, Lei</au><au>Sze, Siu Kwan</au><au>Lim, Su Chi</au><au>Boehm, Bernhard Otto</au><au>Henry, Christiani Jeyakumar</au><au>Leow, Melvin Khee-Shing</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Capsinoids activate brown adipose tissue (BAT) with increased energy expenditure associated with subthreshold 18-fluorine fluorodeoxyglucose uptake in BAT-positive humans confirmed by positron emission tomography scan</atitle><jtitle>The American journal of clinical nutrition</jtitle><addtitle>Am J Clin Nutr</addtitle><date>2018-01-01</date><risdate>2018</risdate><volume>107</volume><issue>1</issue><spage>62</spage><epage>70</epage><pages>62-70</pages><issn>0002-9165</issn><eissn>1938-3207</eissn><abstract>ABSTRACT
Background
Capsinoids are reported to increase energy expenditure (EE) via brown adipose tissue (BAT) stimulation. However, imaging of BAT activation by capsinoids remains limited. Because BAT activation is a potential therapeutic strategy for obesity and related metabolic disorders, we sought to prove that capsinoid-induced BAT activation can be visualized by 18-fluorine fluorodeoxyglucose (18F-FDG) positron emission tomography (PET).
Objective
We compared capsinoids and cold exposure on BAT activation and whole-body EE.
Design
Twenty healthy participants (8 men, 12 women) with a mean age of 26 y (range: 21–35 y) and a body mass index (kg/m2) of 21.7 (range: 18.5–26.0) underwent 18F-FDG PET and whole-body calorimetry after ingestion of 12 mg capsinoids or ≤2 h of cold exposure (∼14.5°C) in a crossover design. Mean standardized uptake values (SUVs) of the region of interest and BAT volumes were calculated. Blood metabolites were measured before and 2 h after each treatment.
Results
All of the participants showed negligible 18F-FDG uptake post-capsinoid ingestion. Upon cold exposure, 12 participants showed avid 18F-FDG uptake into supraclavicular and lateral neck adipose tissues (BAT-positive group), whereas the remaining 8 participants (BAT-negative group) showed undetectable uptake. Capsinoids and cold exposure increased EE, although cold induced a 2-fold increase in whole-body EE and higher fat oxidation, insulin sensitivity, and HDL cholesterol compared with capsinoids.
Conclusions
Capsinoids only increased EE in BAT-positive participants, which suggests that BAT mediates EE evoked by capsinoids. This implies that capsinoids stimulate BAT to a lesser degree than cold exposure as evidenced by 18F-FDG uptake below the presently accepted SUV thresholds defining BAT activation. This trial was registered at www.clinicaltrials.gov as NCT02964442.</abstract><cop>United States</cop><pub>Oxford University Press</pub><pmid>29381803</pmid><doi>10.1093/ajcn/nqx025</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Activation Adipose tissue Adipose tissue (brown) Adipose Tissue, Brown - drug effects Adipose Tissue, Brown - metabolism Adiposity Adult Body Mass Index Body size Calorimetry Calorimetry, Indirect Capsicum - chemistry Cholesterol Clavicle Cold Temperature Cross-Over Studies Design standards Energy Energy expenditure Energy Metabolism Exposure Female Fluorine Fluorine isotopes Fluorodeoxyglucose F18 - administration & dosage Fluorodeoxyglucose F18 - pharmacokinetics High density lipoprotein Humans Image processing Ingestion Insulin Male Metabolic disorders Metabolites Neck NMR Non-Randomized Controlled Trials as Topic Nuclear magnetic resonance Obesity Oxidation Plant Extracts - administration & dosage Positron emission Positron emission tomography Tissues Tomography Young Adult |
| title | Capsinoids activate brown adipose tissue (BAT) with increased energy expenditure associated with subthreshold 18-fluorine fluorodeoxyglucose uptake in BAT-positive humans confirmed by positron emission tomography scan |
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