SIRPα–CD47 Immune Checkpoint Blockade in Anticancer Therapy

Inhibitory immune checkpoint blockade has been one of the most significant advances in anticancer therapy of the past decade. Research so far has largely focused on improving adaptive immune functions, but recent studies have indicated that the signal-regulatory protein (SIRP)α–CD47 pathway, a phago...

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Veröffentlicht in:	Trends in immunology 2018-03, Vol.39 (3), p.173-184
Hauptverfasser:	Veillette, André, Chen, Jun
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, Differentiation - immunology Antigens, Differentiation - metabolism Antineoplastic Combined Chemotherapy Protocols - therapeutic use Apoptosis Cancer therapies CD47 Antigen - antagonists & inhibitors CD47 Antigen - immunology CD47 Antigen - metabolism Dendritic cells Fc receptors Humans Immune checkpoint Immune system Immunity, Innate Immunoglobulins Immunotherapy Immunotherapy - methods Ligands Lymphocytes Macrophages Macrophages - immunology Neoplasms - immunology Neoplasms - therapy Phagocytosis Proteins Receptors Receptors, Immunologic - antagonists & inhibitors Receptors, Immunologic - immunology Receptors, Immunologic - metabolism SHPS-1 protein T cell receptors Therapy Toxicity Tumors
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