The Relationship between GRACE Risk Score and Epicardial Fat Thickness in Patients with Acute Coronary Syndrome
In this study, we aimed to assess the relationship between GS and EFT in ACS patients.Methods We evaulated 162 patients, with non ST segment elevation myocardial infarction (NonSTEMI) between October 2012-February 2013 (115 male, mean age; 66.6±12.8) in the study. According to the laboratory data, i...
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| Veröffentlicht in: | Journal of the American College of Cardiology 2013-10, Vol.62 (18), p.C198-C200 |
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| creator | Gül, İlker Aykan, Ahmet Çağrı Gökdeniz, Tayyar Boyacı, Faruk Kalaycıoğlu, Ezgi Bilgin, Murat Yıldız, Bekir Serhat Zungur, Mustafa Taştan, Ahmet Tamcı, Necdet Batuhan Tavlı, Talat Çelik, Şükrü |
| description | In this study, we aimed to assess the relationship between GS and EFT in ACS patients.Methods We evaulated 162 patients, with non ST segment elevation myocardial infarction (NonSTEMI) between October 2012-February 2013 (115 male, mean age; 66.6±12.8) in the study. According to the laboratory data, it was detected that c-reactive protein and creatinine increased in H-GS and H-GS6M groups. GRACE score < 140 (n=70) GRACE score > 140 (n=92) p value Age (year) 57,2 (±9,1) 73,7 (±10,5) p |
| doi_str_mv | 10.1016/j.jacc.2013.08.566 |
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According to the laboratory data, it was detected that c-reactive protein and creatinine increased in H-GS and H-GS6M groups. GRACE score < 140 (n=70) GRACE score > 140 (n=92) p value Age (year) 57,2 (±9,1) 73,7 (±10,5) p<0,001 Gender (Male/Famale) 56/14 59/33 p=0,020 Systolic Blood Pressure (mmHg) 147,3 (±27,7) 130,3 (±31,1) p<0,001 Diastolic Blood Pressure (mmHg) 85,5 (±16,1 78,1 (±19,5) p=0,010 BMI (kg/m2) 28,5 (±4,4) 26,7 (±3,7) p=0,060 Smoking 35 (%50) 50 (%54,1) p=0,718 Hypertension 40 (%57,1) 44 (%47,8) p=0,155 Diabetes 21 (%30,0) 33 (%35,9) p=0,269 Glucose (mg/dl) 139,6 (±60,3) 146,5 (±70,3) p=0,515 Total Cholesterol(mg/dl) 185,7 (±44,9) 204,2 (±55,9) p=0,022 LDL-Cholesterol (mg/dl) 133,1 (±37,9) 148,5 (±43,9) p=0,019 HDL-Cholesterol (mg/dl) 40,9 (±15,9) 39,9 (±9,8) p=0,627 Triglyceride (mg/dl) 124,8 (±71,4) 131,3 (± 96,8) p=0,641 CRP (mg/dl) 1,63 (±3,4) 2,68 (±4,38) p=0,013 Creatinine (mg/dl) 0,84 (±0,2) 1,18(± 0,57) p<0,001 Troponin-I (ng/dl) 31,6 (±30,0) 31,1 (±28,1) p=0,951 Left Ventricle Ejection Fraction (%) 47,8 (±10,2) 43,3 (±10,5) p=0,008 Interventricular septum (mm) 10,1(±1,2) 10,1 (±1,36) p=0,726 Posterior Wall (mm) 9,8 (± 1,12) 9,9 (±1,26) p=0,761 Left Ventricle Mass Index (g/m2) 94,3 (±22,4) 109,4 (±28,4) p=0,002 Epikardiyal fat thickness (end-systol, mm) 0,72 (±0,17) 0,81 (±0,12) p<0,001 Epikardiyal fat thickness (end-diastol, mm) 0,46 (±0,13) 0,54 (±0,10) p<0,001 TAPSE (mm) 20,9 (±4,1) 19,4 (±3,6) p=0,017 SYNTAX 20,6 (±10,1) 21,2 (± 9,9) p=0,625 LAD lesion 29 (%41,4) 35 (%38,0) p=0,352 Cx lesion 17 (%24,3) 16 (%17,4) p=0,156 RCA lesion 24 (%34,3) 41 (%44,6) p=0,081 Intensive-care-unit stay (day) 3,3 (±1,2) 4,3 (±2,9) p=0,019 In-hospital stay (day) 5,6 (±2,5) 6,9 (±3,8) p=0,020 Table 1 Generel characteristics of the patients according to in hospital GRACE score GRACE score < 108 (Low-moderate risk group) (n=77) GRACE score > 108 (High risk group) (n=85) p value Age (year) 57,2 (±9,2) 75,1 (±9,3) p<0,001 Gender (male/female) 62/15 53/32 p=0,011 Systolic BP (mmHg) 144,6 (±28,5) 131,3 (±31,5) p=0,006 Diastolic BP (mmHg) 84,5 (±16,6) 78,3 (±19,5) p=0,031 BMI (kg/m2) 27,2 (±4,2) 26,8 (±3,8) p=0,330 Smoking 36 (%46,7) 45 (%52,9) p=0,718 Hypertension 41 (%53,2) 43 (%50,6) p=0,155 Diabetes 22 (%28,6) 32 (%37,6) p=0,269 Blood glucose (mg/dl) 138,2 (±59,8) 148,3 (±71,2) p=0,481 Total Kolesterol (mg/dl) 206,2 (±55,0) 183,1 (±44,1) p=0,166 LDL Kolesterol (mg/dl) 147,7 (±43,0) 131,6 (±38,1) p=0,226 HDL Cholesterol (mg/dl) 41,1 (±14,4) 39,8 (±9,4) p=0,723 Triglyceride (mg/dl) 130,2 (±82,3) 126,8 (± 90,6) p=0,867 CRP (mg/l) 1,73 (±3,71) 2,68 (±4,25) p=0,050 Creatinine (mg/dl) 0,84 (±0,21) 1,21(± 0,58) p<0,001 Troponin-I (ng/ml) 31,5 (±31,0) 31,2 (±29,5) p=0,869 LV Ejection Fraction (%) 47,3 (±10,1) 43,2 (±10,6) p=0,013 Interventriküler septum (mm) 10,0(±1,3) 10,1 (±1,3) p=0.869 Posterior Wall (mm) 9,9 (± 1,1) 9,7 (±1,2) p=0,875 LV mass index(g/m2) 94,7 (±24,8) 109,8 (±26,6) p=0,004 Epicardial fat thickness(diastol) (mm) 0,72 (±0,18) 0,83 (±0,13) p<0,001 Epicardial fat thickness(diastol) (mm) 0,46 (±0,12) 0,53 (±0,14) p<0,001 TAPSE (mm) 20,7 (±3,9) 19,3 (±3,6) p=0,010 SYNTAX score 20,6 (±10,2) 21,3 (± 9,7) p=0,685 LAD lesion 29 (%37,7) 35 (%41,2) p=0,661 Cx lesion 18 (%23,4) 15 (%17,6) p=0,452 RCA lesion 30 (%39,0) 35 (%41,2) p=0,713 Intensive care unit stay (days) 3,5 (±1,4) 4,4 (±2,9) p=0,003 In hospital stay (days) 5,7 (±2,5) 6,9 (±3,8) p=0.004 Table 2 General charasteristics of the patients according to the six month GRACE score Cut-off (cm) Sensitivity Specificity AUC 95% Confidence Interval EFT end sistol / GS 0.765 %67 %64 0.699 0.613-0.785 EFT end diastol / GS 0.465 %82 %60 0.702 0.613-0.785 EFT end sistol / GS-6M 0.725 %82 %62 0.720 0.629-0.811 EFT end diastol/ GS-6M 0.465 %80 %64 0.714 0.624-0.804 Table 3 ROC analysis results Correlation factor (r) End sistolic EFT - GS r=0.387 End diastolic EFT - GS r=0.438 End sistolic EFT - GS6M r=0.406 End diastolic EFT - GS6M r=0.455 End sistolic EFT - SYNTAX score r=0.243 End diastolic EFT - SYNTAX score r=0.202 Correlation table]]></description><identifier>ISSN: 0735-1097</identifier><identifier>EISSN: 1558-3597</identifier><identifier>DOI: 10.1016/j.jacc.2013.08.566</identifier><language>eng</language><publisher>New York: Elsevier Inc</publisher><subject>Acute coronary syndromes ; Body mass index ; Cardiology ; Cardiovascular ; Cholesterol ; Confidence intervals ; Coronary vessels ; Correlation analysis ; Correlation coefficients ; Creatinine ; Diabetes ; Glucose ; Hypertension ; Internal Medicine ; Low density lipoprotein ; Myocardial infarction ; Proteins ; Risk ; Septum ; Smoking ; Syntax ; Thickness ; Triglycerides ; Veins & arteries</subject><ispartof>Journal of the American College of Cardiology, 2013-10, Vol.62 (18), p.C198-C200</ispartof><rights>2013</rights><rights>Copyright Elsevier Limited Oct 29, 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jacc.2013.08.566$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,3548,27923,27924,45994</link.rule.ids></links><search><creatorcontrib>Gül, İlker</creatorcontrib><creatorcontrib>Aykan, Ahmet Çağrı</creatorcontrib><creatorcontrib>Gökdeniz, Tayyar</creatorcontrib><creatorcontrib>Boyacı, Faruk</creatorcontrib><creatorcontrib>Kalaycıoğlu, Ezgi</creatorcontrib><creatorcontrib>Bilgin, Murat</creatorcontrib><creatorcontrib>Yıldız, Bekir Serhat</creatorcontrib><creatorcontrib>Zungur, Mustafa</creatorcontrib><creatorcontrib>Taştan, Ahmet</creatorcontrib><creatorcontrib>Tamcı, Necdet Batuhan</creatorcontrib><creatorcontrib>Tavlı, Talat</creatorcontrib><creatorcontrib>Çelik, Şükrü</creatorcontrib><title>The Relationship between GRACE Risk Score and Epicardial Fat Thickness in Patients with Acute Coronary Syndrome</title><title>Journal of the American College of Cardiology</title><description><![CDATA[In this study, we aimed to assess the relationship between GS and EFT in ACS patients.Methods We evaulated 162 patients, with non ST segment elevation myocardial infarction (NonSTEMI) between October 2012-February 2013 (115 male, mean age; 66.6±12.8) in the study. According to the laboratory data, it was detected that c-reactive protein and creatinine increased in H-GS and H-GS6M groups. GRACE score < 140 (n=70) GRACE score > 140 (n=92) p value Age (year) 57,2 (±9,1) 73,7 (±10,5) p<0,001 Gender (Male/Famale) 56/14 59/33 p=0,020 Systolic Blood Pressure (mmHg) 147,3 (±27,7) 130,3 (±31,1) p<0,001 Diastolic Blood Pressure (mmHg) 85,5 (±16,1 78,1 (±19,5) p=0,010 BMI (kg/m2) 28,5 (±4,4) 26,7 (±3,7) p=0,060 Smoking 35 (%50) 50 (%54,1) p=0,718 Hypertension 40 (%57,1) 44 (%47,8) p=0,155 Diabetes 21 (%30,0) 33 (%35,9) p=0,269 Glucose (mg/dl) 139,6 (±60,3) 146,5 (±70,3) p=0,515 Total Cholesterol(mg/dl) 185,7 (±44,9) 204,2 (±55,9) p=0,022 LDL-Cholesterol (mg/dl) 133,1 (±37,9) 148,5 (±43,9) p=0,019 HDL-Cholesterol (mg/dl) 40,9 (±15,9) 39,9 (±9,8) p=0,627 Triglyceride (mg/dl) 124,8 (±71,4) 131,3 (± 96,8) p=0,641 CRP (mg/dl) 1,63 (±3,4) 2,68 (±4,38) p=0,013 Creatinine (mg/dl) 0,84 (±0,2) 1,18(± 0,57) p<0,001 Troponin-I (ng/dl) 31,6 (±30,0) 31,1 (±28,1) p=0,951 Left Ventricle Ejection Fraction (%) 47,8 (±10,2) 43,3 (±10,5) p=0,008 Interventricular septum (mm) 10,1(±1,2) 10,1 (±1,36) p=0,726 Posterior Wall (mm) 9,8 (± 1,12) 9,9 (±1,26) p=0,761 Left Ventricle Mass Index (g/m2) 94,3 (±22,4) 109,4 (±28,4) p=0,002 Epikardiyal fat thickness (end-systol, mm) 0,72 (±0,17) 0,81 (±0,12) p<0,001 Epikardiyal fat thickness (end-diastol, mm) 0,46 (±0,13) 0,54 (±0,10) p<0,001 TAPSE (mm) 20,9 (±4,1) 19,4 (±3,6) p=0,017 SYNTAX 20,6 (±10,1) 21,2 (± 9,9) p=0,625 LAD lesion 29 (%41,4) 35 (%38,0) p=0,352 Cx lesion 17 (%24,3) 16 (%17,4) p=0,156 RCA lesion 24 (%34,3) 41 (%44,6) p=0,081 Intensive-care-unit stay (day) 3,3 (±1,2) 4,3 (±2,9) p=0,019 In-hospital stay (day) 5,6 (±2,5) 6,9 (±3,8) p=0,020 Table 1 Generel characteristics of the patients according to in hospital GRACE score GRACE score < 108 (Low-moderate risk group) (n=77) GRACE score > 108 (High risk group) (n=85) p value Age (year) 57,2 (±9,2) 75,1 (±9,3) p<0,001 Gender (male/female) 62/15 53/32 p=0,011 Systolic BP (mmHg) 144,6 (±28,5) 131,3 (±31,5) p=0,006 Diastolic BP (mmHg) 84,5 (±16,6) 78,3 (±19,5) p=0,031 BMI (kg/m2) 27,2 (±4,2) 26,8 (±3,8) p=0,330 Smoking 36 (%46,7) 45 (%52,9) p=0,718 Hypertension 41 (%53,2) 43 (%50,6) p=0,155 Diabetes 22 (%28,6) 32 (%37,6) p=0,269 Blood glucose (mg/dl) 138,2 (±59,8) 148,3 (±71,2) p=0,481 Total Kolesterol (mg/dl) 206,2 (±55,0) 183,1 (±44,1) p=0,166 LDL Kolesterol (mg/dl) 147,7 (±43,0) 131,6 (±38,1) p=0,226 HDL Cholesterol (mg/dl) 41,1 (±14,4) 39,8 (±9,4) p=0,723 Triglyceride (mg/dl) 130,2 (±82,3) 126,8 (± 90,6) p=0,867 CRP (mg/l) 1,73 (±3,71) 2,68 (±4,25) p=0,050 Creatinine (mg/dl) 0,84 (±0,21) 1,21(± 0,58) p<0,001 Troponin-I (ng/ml) 31,5 (±31,0) 31,2 (±29,5) p=0,869 LV Ejection Fraction (%) 47,3 (±10,1) 43,2 (±10,6) p=0,013 Interventriküler septum (mm) 10,0(±1,3) 10,1 (±1,3) p=0.869 Posterior Wall (mm) 9,9 (± 1,1) 9,7 (±1,2) p=0,875 LV mass index(g/m2) 94,7 (±24,8) 109,8 (±26,6) p=0,004 Epicardial fat thickness(diastol) (mm) 0,72 (±0,18) 0,83 (±0,13) p<0,001 Epicardial fat thickness(diastol) (mm) 0,46 (±0,12) 0,53 (±0,14) p<0,001 TAPSE (mm) 20,7 (±3,9) 19,3 (±3,6) p=0,010 SYNTAX score 20,6 (±10,2) 21,3 (± 9,7) p=0,685 LAD lesion 29 (%37,7) 35 (%41,2) p=0,661 Cx lesion 18 (%23,4) 15 (%17,6) p=0,452 RCA lesion 30 (%39,0) 35 (%41,2) p=0,713 Intensive care unit stay (days) 3,5 (±1,4) 4,4 (±2,9) p=0,003 In hospital stay (days) 5,7 (±2,5) 6,9 (±3,8) p=0.004 Table 2 General charasteristics of the patients according to the six month GRACE score Cut-off (cm) Sensitivity Specificity AUC 95% Confidence Interval EFT end sistol / GS 0.765 %67 %64 0.699 0.613-0.785 EFT end diastol / GS 0.465 %82 %60 0.702 0.613-0.785 EFT end sistol / GS-6M 0.725 %82 %62 0.720 0.629-0.811 EFT end diastol/ GS-6M 0.465 %80 %64 0.714 0.624-0.804 Table 3 ROC analysis results Correlation factor (r) End sistolic EFT - GS r=0.387 End diastolic EFT - GS r=0.438 End sistolic EFT - GS6M r=0.406 End diastolic EFT - GS6M r=0.455 End sistolic EFT - SYNTAX score r=0.243 End diastolic EFT - SYNTAX score r=0.202 Correlation table]]></description><subject>Acute coronary syndromes</subject><subject>Body mass index</subject><subject>Cardiology</subject><subject>Cardiovascular</subject><subject>Cholesterol</subject><subject>Confidence intervals</subject><subject>Coronary vessels</subject><subject>Correlation analysis</subject><subject>Correlation coefficients</subject><subject>Creatinine</subject><subject>Diabetes</subject><subject>Glucose</subject><subject>Hypertension</subject><subject>Internal Medicine</subject><subject>Low density lipoprotein</subject><subject>Myocardial infarction</subject><subject>Proteins</subject><subject>Risk</subject><subject>Septum</subject><subject>Smoking</subject><subject>Syntax</subject><subject>Thickness</subject><subject>Triglycerides</subject><subject>Veins & arteries</subject><issn>0735-1097</issn><issn>1558-3597</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><recordid>eNp9kU9rGzEQxUVJoU7aL9CToOfdjqTV_oFSMMZJC4EE2z0LrXYWa72RXGmd4G8fLS495JDTMDC_mffeEPKVQc6Ald-HfNDG5ByYyKHOZVl-IAsmZZ0J2VRXZAGVkBmDpvpErmMcAKCsWbMgfrdHusFRT9a7uLdH2uL0gujo3Wa5WtONjQe6NT4g1a6j66M1OnRWj_RWT3S3t-bgMEZqHX1MO9BNkb7YaU-X5jQhXfngnQ5nuj27Lvgn_Ew-9nqM-OVfvSF_bte71a_s_uHu92p5nxnORZnptjWl1CW0UJuqb3hbM9Fq3vUFZ8K0tUwW60JoKIq-aVotU8cQAIuiaSojbsi3y95j8H9PGCc1-FNw6aTiAJUUDEqZpvhlygQfY8BeHYN9SnoVAzUHqwY1B6vmYBXUKl1N0I8LhEn_s8WgoknGDXY2oJlU5-37-M83uBmtS7GOBzxj_C-TqcgVqO38uflxTIBIOBevvueVSw</recordid><startdate>20131029</startdate><enddate>20131029</enddate><creator>Gül, İlker</creator><creator>Aykan, Ahmet Çağrı</creator><creator>Gökdeniz, Tayyar</creator><creator>Boyacı, Faruk</creator><creator>Kalaycıoğlu, Ezgi</creator><creator>Bilgin, Murat</creator><creator>Yıldız, Bekir Serhat</creator><creator>Zungur, Mustafa</creator><creator>Taştan, Ahmet</creator><creator>Tamcı, Necdet Batuhan</creator><creator>Tavlı, Talat</creator><creator>Çelik, Şükrü</creator><general>Elsevier Inc</general><general>Elsevier Limited</general><scope>6I.</scope><scope>AAFTH</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope></search><sort><creationdate>20131029</creationdate><title>The Relationship between GRACE Risk Score and Epicardial Fat Thickness in Patients with Acute Coronary Syndrome</title><author>Gül, İlker ; Aykan, Ahmet Çağrı ; Gökdeniz, Tayyar ; Boyacı, Faruk ; Kalaycıoğlu, Ezgi ; Bilgin, Murat ; Yıldız, Bekir Serhat ; Zungur, Mustafa ; Taştan, Ahmet ; Tamcı, Necdet Batuhan ; Tavlı, Talat ; Çelik, Şükrü</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2236-abbc65a60b08c7f92b813ba2df4213cb85566843a044f99ba56841e00e44997c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Acute coronary syndromes</topic><topic>Body mass index</topic><topic>Cardiology</topic><topic>Cardiovascular</topic><topic>Cholesterol</topic><topic>Confidence intervals</topic><topic>Coronary vessels</topic><topic>Correlation analysis</topic><topic>Correlation coefficients</topic><topic>Creatinine</topic><topic>Diabetes</topic><topic>Glucose</topic><topic>Hypertension</topic><topic>Internal Medicine</topic><topic>Low density lipoprotein</topic><topic>Myocardial infarction</topic><topic>Proteins</topic><topic>Risk</topic><topic>Septum</topic><topic>Smoking</topic><topic>Syntax</topic><topic>Thickness</topic><topic>Triglycerides</topic><topic>Veins & arteries</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gül, İlker</creatorcontrib><creatorcontrib>Aykan, Ahmet Çağrı</creatorcontrib><creatorcontrib>Gökdeniz, Tayyar</creatorcontrib><creatorcontrib>Boyacı, Faruk</creatorcontrib><creatorcontrib>Kalaycıoğlu, Ezgi</creatorcontrib><creatorcontrib>Bilgin, Murat</creatorcontrib><creatorcontrib>Yıldız, Bekir Serhat</creatorcontrib><creatorcontrib>Zungur, Mustafa</creatorcontrib><creatorcontrib>Taştan, Ahmet</creatorcontrib><creatorcontrib>Tamcı, Necdet Batuhan</creatorcontrib><creatorcontrib>Tavlı, Talat</creatorcontrib><creatorcontrib>Çelik, Şükrü</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><jtitle>Journal of the American College of Cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gül, İlker</au><au>Aykan, Ahmet Çağrı</au><au>Gökdeniz, Tayyar</au><au>Boyacı, Faruk</au><au>Kalaycıoğlu, Ezgi</au><au>Bilgin, Murat</au><au>Yıldız, Bekir Serhat</au><au>Zungur, Mustafa</au><au>Taştan, Ahmet</au><au>Tamcı, Necdet Batuhan</au><au>Tavlı, Talat</au><au>Çelik, Şükrü</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Relationship between GRACE Risk Score and Epicardial Fat Thickness in Patients with Acute Coronary Syndrome</atitle><jtitle>Journal of the American College of Cardiology</jtitle><date>2013-10-29</date><risdate>2013</risdate><volume>62</volume><issue>18</issue><spage>C198</spage><epage>C200</epage><pages>C198-C200</pages><issn>0735-1097</issn><eissn>1558-3597</eissn><abstract><![CDATA[In this study, we aimed to assess the relationship between GS and EFT in ACS patients.Methods We evaulated 162 patients, with non ST segment elevation myocardial infarction (NonSTEMI) between October 2012-February 2013 (115 male, mean age; 66.6±12.8) in the study. According to the laboratory data, it was detected that c-reactive protein and creatinine increased in H-GS and H-GS6M groups. GRACE score < 140 (n=70) GRACE score > 140 (n=92) p value Age (year) 57,2 (±9,1) 73,7 (±10,5) p<0,001 Gender (Male/Famale) 56/14 59/33 p=0,020 Systolic Blood Pressure (mmHg) 147,3 (±27,7) 130,3 (±31,1) p<0,001 Diastolic Blood Pressure (mmHg) 85,5 (±16,1 78,1 (±19,5) p=0,010 BMI (kg/m2) 28,5 (±4,4) 26,7 (±3,7) p=0,060 Smoking 35 (%50) 50 (%54,1) p=0,718 Hypertension 40 (%57,1) 44 (%47,8) p=0,155 Diabetes 21 (%30,0) 33 (%35,9) p=0,269 Glucose (mg/dl) 139,6 (±60,3) 146,5 (±70,3) p=0,515 Total Cholesterol(mg/dl) 185,7 (±44,9) 204,2 (±55,9) p=0,022 LDL-Cholesterol (mg/dl) 133,1 (±37,9) 148,5 (±43,9) p=0,019 HDL-Cholesterol (mg/dl) 40,9 (±15,9) 39,9 (±9,8) p=0,627 Triglyceride (mg/dl) 124,8 (±71,4) 131,3 (± 96,8) p=0,641 CRP (mg/dl) 1,63 (±3,4) 2,68 (±4,38) p=0,013 Creatinine (mg/dl) 0,84 (±0,2) 1,18(± 0,57) p<0,001 Troponin-I (ng/dl) 31,6 (±30,0) 31,1 (±28,1) p=0,951 Left Ventricle Ejection Fraction (%) 47,8 (±10,2) 43,3 (±10,5) p=0,008 Interventricular septum (mm) 10,1(±1,2) 10,1 (±1,36) p=0,726 Posterior Wall (mm) 9,8 (± 1,12) 9,9 (±1,26) p=0,761 Left Ventricle Mass Index (g/m2) 94,3 (±22,4) 109,4 (±28,4) p=0,002 Epikardiyal fat thickness (end-systol, mm) 0,72 (±0,17) 0,81 (±0,12) p<0,001 Epikardiyal fat thickness (end-diastol, mm) 0,46 (±0,13) 0,54 (±0,10) p<0,001 TAPSE (mm) 20,9 (±4,1) 19,4 (±3,6) p=0,017 SYNTAX 20,6 (±10,1) 21,2 (± 9,9) p=0,625 LAD lesion 29 (%41,4) 35 (%38,0) p=0,352 Cx lesion 17 (%24,3) 16 (%17,4) p=0,156 RCA lesion 24 (%34,3) 41 (%44,6) p=0,081 Intensive-care-unit stay (day) 3,3 (±1,2) 4,3 (±2,9) p=0,019 In-hospital stay (day) 5,6 (±2,5) 6,9 (±3,8) p=0,020 Table 1 Generel characteristics of the patients according to in hospital GRACE score GRACE score < 108 (Low-moderate risk group) (n=77) GRACE score > 108 (High risk group) (n=85) p value Age (year) 57,2 (±9,2) 75,1 (±9,3) p<0,001 Gender (male/female) 62/15 53/32 p=0,011 Systolic BP (mmHg) 144,6 (±28,5) 131,3 (±31,5) p=0,006 Diastolic BP (mmHg) 84,5 (±16,6) 78,3 (±19,5) p=0,031 BMI (kg/m2) 27,2 (±4,2) 26,8 (±3,8) p=0,330 Smoking 36 (%46,7) 45 (%52,9) p=0,718 Hypertension 41 (%53,2) 43 (%50,6) p=0,155 Diabetes 22 (%28,6) 32 (%37,6) p=0,269 Blood glucose (mg/dl) 138,2 (±59,8) 148,3 (±71,2) p=0,481 Total Kolesterol (mg/dl) 206,2 (±55,0) 183,1 (±44,1) p=0,166 LDL Kolesterol (mg/dl) 147,7 (±43,0) 131,6 (±38,1) p=0,226 HDL Cholesterol (mg/dl) 41,1 (±14,4) 39,8 (±9,4) p=0,723 Triglyceride (mg/dl) 130,2 (±82,3) 126,8 (± 90,6) p=0,867 CRP (mg/l) 1,73 (±3,71) 2,68 (±4,25) p=0,050 Creatinine (mg/dl) 0,84 (±0,21) 1,21(± 0,58) p<0,001 Troponin-I (ng/ml) 31,5 (±31,0) 31,2 (±29,5) p=0,869 LV Ejection Fraction (%) 47,3 (±10,1) 43,2 (±10,6) p=0,013 Interventriküler septum (mm) 10,0(±1,3) 10,1 (±1,3) p=0.869 Posterior Wall (mm) 9,9 (± 1,1) 9,7 (±1,2) p=0,875 LV mass index(g/m2) 94,7 (±24,8) 109,8 (±26,6) p=0,004 Epicardial fat thickness(diastol) (mm) 0,72 (±0,18) 0,83 (±0,13) p<0,001 Epicardial fat thickness(diastol) (mm) 0,46 (±0,12) 0,53 (±0,14) p<0,001 TAPSE (mm) 20,7 (±3,9) 19,3 (±3,6) p=0,010 SYNTAX score 20,6 (±10,2) 21,3 (± 9,7) p=0,685 LAD lesion 29 (%37,7) 35 (%41,2) p=0,661 Cx lesion 18 (%23,4) 15 (%17,6) p=0,452 RCA lesion 30 (%39,0) 35 (%41,2) p=0,713 Intensive care unit stay (days) 3,5 (±1,4) 4,4 (±2,9) p=0,003 In hospital stay (days) 5,7 (±2,5) 6,9 (±3,8) p=0.004 Table 2 General charasteristics of the patients according to the six month GRACE score Cut-off (cm) Sensitivity Specificity AUC 95% Confidence Interval EFT end sistol / GS 0.765 %67 %64 0.699 0.613-0.785 EFT end diastol / GS 0.465 %82 %60 0.702 0.613-0.785 EFT end sistol / GS-6M 0.725 %82 %62 0.720 0.629-0.811 EFT end diastol/ GS-6M 0.465 %80 %64 0.714 0.624-0.804 Table 3 ROC analysis results Correlation factor (r) End sistolic EFT - GS r=0.387 End diastolic EFT - GS r=0.438 End sistolic EFT - GS6M r=0.406 End diastolic EFT - GS6M r=0.455 End sistolic EFT - SYNTAX score r=0.243 End diastolic EFT - SYNTAX score r=0.202 Correlation table]]></abstract><cop>New York</cop><pub>Elsevier Inc</pub><doi>10.1016/j.jacc.2013.08.566</doi><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0735-1097 |
| ispartof | Journal of the American College of Cardiology, 2013-10, Vol.62 (18), p.C198-C200 |
| issn | 0735-1097 1558-3597 |
| language | eng |
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| source | ScienceDirect Journals (5 years ago - present); EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Acute coronary syndromes Body mass index Cardiology Cardiovascular Cholesterol Confidence intervals Coronary vessels Correlation analysis Correlation coefficients Creatinine Diabetes Glucose Hypertension Internal Medicine Low density lipoprotein Myocardial infarction Proteins Risk Septum Smoking Syntax Thickness Triglycerides Veins & arteries |
| title | The Relationship between GRACE Risk Score and Epicardial Fat Thickness in Patients with Acute Coronary Syndrome |
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