Sexual Dimorphism in Eosinophilic Esophagitis: Roles of Differential Chemokine and Profibrogenic Expression
Results Immunohistochemical staining of esophageal biopsies from our EoE cohort (N = 138 patients; 110 males and 28 females) demonstrated significantly more TGF-β1-positive cells in female than male patients (p
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| Veröffentlicht in: | Journal of allergy and clinical immunology 2018-02, Vol.141 (2), p.AB205-AB205 |
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| container_title | Journal of allergy and clinical immunology |
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| creator | Nhu, Quan M. Duong, Loan D. Rawson, Renee Dohil, Ranjan Kurten, Richard C. Moawad, Fouad J. Aceves, Seema S. |
| description | Results Immunohistochemical staining of esophageal biopsies from our EoE cohort (N = 138 patients; 110 males and 28 females) demonstrated significantly more TGF-β1-positive cells in female than male patients (p |
| doi_str_mv | 10.1016/j.jaci.2017.12.648 |
| format | Article |
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Primary human esophageal fibroblasts from age- and race-matched EoE and healthy male esophagi responded to TGF-β1 stimulation with more α-sma and col1α1 mRNAs than female cells (EoE group: p<0.0001 and p<0.001, respectively; healthy controls: p< 0.0001 and p<0.01, respectively).</description><identifier>ISSN: 0091-6749</identifier><identifier>EISSN: 1097-6825</identifier><identifier>DOI: 10.1016/j.jaci.2017.12.648</identifier><language>eng</language><publisher>St. Louis: Elsevier Inc</publisher><subject>Autoimmune diseases ; Esophageal diseases ; Esophagitis ; Esophagus ; Females ; Fibroblasts ; Gastrointestinal diseases ; Leukocytes (eosinophilic) ; Males ; Sexual dimorphism ; Transforming growth factor-b1</subject><ispartof>Journal of allergy and clinical immunology, 2018-02, Vol.141 (2), p.AB205-AB205</ispartof><rights>2017</rights><rights>Copyright Elsevier Science Ltd. 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Primary human esophageal fibroblasts from age- and race-matched EoE and healthy male esophagi responded to TGF-β1 stimulation with more α-sma and col1α1 mRNAs than female cells (EoE group: p<0.0001 and p<0.001, respectively; healthy controls: p< 0.0001 and p<0.01, respectively).</description><subject>Autoimmune diseases</subject><subject>Esophageal diseases</subject><subject>Esophagitis</subject><subject>Esophagus</subject><subject>Females</subject><subject>Fibroblasts</subject><subject>Gastrointestinal diseases</subject><subject>Leukocytes (eosinophilic)</subject><subject>Males</subject><subject>Sexual dimorphism</subject><subject>Transforming growth factor-b1</subject><issn>0091-6749</issn><issn>1097-6825</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp9kFtLw0AQhRdRsFb_gE8BnxP3kqv4IrVeoKBo35ckO2knTXbjbir137uhPvsyMwfONzMcQq4ZjRhl6W0btWWNEacsixiP0jg_ITNGiyxMc56ckhmlBQvTLC7OyYVzLfVa5MWM7D7hsC-74BF7Y4ctuj5AHSyNQ2287LAOls5P5QZHdHfBh-nABabxQNOABT2ipxdb6M0ONQSlVsG7NQ1W1mxAT_hhsOAcGn1Jzpqyc3D11-dk_bRcL17C1dvz6-JhFdYszfMw5jSBrBGliKHgSaZYAiKOE1X5sSq4EE3FsgJyKuIioVkiqFKpqlVCc1FRMSc3x7WDNV97cKNszd5qf1Fy6u2-pLl38aOrtsY5C40cLPal_ZGMyilT2copUzllKhmXPlMP3R8h8O9_I1jpagRdg0IL9SiVwf_wXx5xgBo</recordid><startdate>201802</startdate><enddate>201802</enddate><creator>Nhu, Quan M.</creator><creator>Duong, Loan D.</creator><creator>Rawson, Renee</creator><creator>Dohil, Ranjan</creator><creator>Kurten, Richard C.</creator><creator>Moawad, Fouad J.</creator><creator>Aceves, Seema S.</creator><general>Elsevier Inc</general><general>Elsevier Limited</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7SS</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope></search><sort><creationdate>201802</creationdate><title>Sexual Dimorphism in Eosinophilic Esophagitis: Roles of Differential Chemokine and Profibrogenic Expression</title><author>Nhu, Quan M. ; Duong, Loan D. ; Rawson, Renee ; Dohil, Ranjan ; Kurten, Richard C. ; Moawad, Fouad J. ; Aceves, Seema S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1688-4205e7f3a34e9257d15e3445db7d1b9233fb179e80349507530dd6dcd5083b03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Autoimmune diseases</topic><topic>Esophageal diseases</topic><topic>Esophagitis</topic><topic>Esophagus</topic><topic>Females</topic><topic>Fibroblasts</topic><topic>Gastrointestinal diseases</topic><topic>Leukocytes (eosinophilic)</topic><topic>Males</topic><topic>Sexual dimorphism</topic><topic>Transforming growth factor-b1</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nhu, Quan M.</creatorcontrib><creatorcontrib>Duong, Loan D.</creatorcontrib><creatorcontrib>Rawson, Renee</creatorcontrib><creatorcontrib>Dohil, Ranjan</creatorcontrib><creatorcontrib>Kurten, Richard C.</creatorcontrib><creatorcontrib>Moawad, Fouad J.</creatorcontrib><creatorcontrib>Aceves, Seema S.</creatorcontrib><collection>CrossRef</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><jtitle>Journal of allergy and clinical immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nhu, Quan M.</au><au>Duong, Loan D.</au><au>Rawson, Renee</au><au>Dohil, Ranjan</au><au>Kurten, Richard C.</au><au>Moawad, Fouad J.</au><au>Aceves, Seema S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sexual Dimorphism in Eosinophilic Esophagitis: Roles of Differential Chemokine and Profibrogenic Expression</atitle><jtitle>Journal of allergy and clinical immunology</jtitle><date>2018-02</date><risdate>2018</risdate><volume>141</volume><issue>2</issue><spage>AB205</spage><epage>AB205</epage><pages>AB205-AB205</pages><issn>0091-6749</issn><eissn>1097-6825</eissn><abstract>Results Immunohistochemical staining of esophageal biopsies from our EoE cohort (N = 138 patients; 110 males and 28 females) demonstrated significantly more TGF-β1-positive cells in female than male patients (p<0.001) but no difference in phosphorylated-SMAD2/3 expression, suggesting a potential cell-intrinsic differential response to TGF-β1 signaling. Primary human esophageal fibroblasts from age- and race-matched EoE and healthy male esophagi responded to TGF-β1 stimulation with more α-sma and col1α1 mRNAs than female cells (EoE group: p<0.0001 and p<0.001, respectively; healthy controls: p< 0.0001 and p<0.01, respectively).</abstract><cop>St. Louis</cop><pub>Elsevier Inc</pub><doi>10.1016/j.jaci.2017.12.648</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Autoimmune diseases Esophageal diseases Esophagitis Esophagus Females Fibroblasts Gastrointestinal diseases Leukocytes (eosinophilic) Males Sexual dimorphism Transforming growth factor-b1 |
| title | Sexual Dimorphism in Eosinophilic Esophagitis: Roles of Differential Chemokine and Profibrogenic Expression |
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