Bisphenol A(BPA) alters molecular signaling in Immune cells that promotes the development of childhood asthma
The purpose of this study was to test the hypothesis that fetal exposure of immune cells to environmental estrogens (EEs) enhances the allergic sensitization, that underlies childhood asthma, by initiating signaling in these cells. Methods T cell lines (TIB-152 and CCL-119) were exposed to varying c...
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| Veröffentlicht in: | Journal of allergy and clinical immunology 2018-02, Vol.141 (2), p.AB28-AB28 |
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| container_issue | 2 |
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| container_title | Journal of allergy and clinical immunology |
| container_volume | 141 |
| creator | Murakami, Youko Fahmy, Sahar Choudhury, Barun K. Goldblum, Randall M. Midoro-Horiuti, Terumi |
| description | The purpose of this study was to test the hypothesis that fetal exposure of immune cells to environmental estrogens (EEs) enhances the allergic sensitization, that underlies childhood asthma, by initiating signaling in these cells. Methods T cell lines (TIB-152 and CCL-119) were exposed to varying concentrations (10-12-10-6 M) of estradiol (E2), BPA, Bisphenol S (BPS) or BPA combined with 10-9M E2 for 120 min in vitro. |
| doi_str_mv | 10.1016/j.jaci.2017.12.087 |
| format | Article |
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| ispartof | Journal of allergy and clinical immunology, 2018-02, Vol.141 (2), p.AB28-AB28 |
| issn | 0091-6749 1097-6825 |
| language | eng |
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| source | Elsevier ScienceDirect Journals |
| subjects | Asthma Bisphenol A Children Lymphocytes T Phenols Phosphorylation Prenatal exposure |
| title | Bisphenol A(BPA) alters molecular signaling in Immune cells that promotes the development of childhood asthma |
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