Bisphenol A(BPA) alters molecular signaling in Immune cells that promotes the development of childhood asthma

Bisphenol A(BPA) alters molecular signaling in Immune cells that promotes the development of childhood asthma

The purpose of this study was to test the hypothesis that fetal exposure of immune cells to environmental estrogens (EEs) enhances the allergic sensitization, that underlies childhood asthma, by initiating signaling in these cells. Methods T cell lines (TIB-152 and CCL-119) were exposed to varying c...

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Veröffentlicht in:Journal of allergy and clinical immunology 2018-02, Vol.141 (2), p.AB28-AB28
Hauptverfasser: Murakami, Youko, Fahmy, Sahar, Choudhury, Barun K., Goldblum, Randall M., Midoro-Horiuti, Terumi
Format: Artikel
Sprache:eng
Schlagworte:
Asthma
Bisphenol A
Children
Lymphocytes T
Phenols
Phosphorylation
Prenatal exposure
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Zusammenfassung:The purpose of this study was to test the hypothesis that fetal exposure of immune cells to environmental estrogens (EEs) enhances the allergic sensitization, that underlies childhood asthma, by initiating signaling in these cells. Methods T cell lines (TIB-152 and CCL-119) were exposed to varying concentrations (10-12-10-6 M) of estradiol (E2), BPA, Bisphenol S (BPS) or BPA combined with 10-9M E2 for 120 min in vitro.
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2017.12.087