lncRNA AK017368 promotes proliferation and suppresses differentiation of myoblasts in skeletal muscle development by attenuating the function of miR-30c

Long noncoding RNAs (lncRNAs) have been reported to play diverse roles in biologic and pathologic processes, including myogenesis. We found that lncRNA is highly expressed in skeletal muscle cells. Functional analyses showed that overexpression of promoted proliferation and restrained differentiatio...

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Veröffentlicht in:	The FASEB journal 2018-01, Vol.32 (1), p.377-389
Hauptverfasser:	Liang, Tingting, Zhou, Bo, Shi, Lei, Wang, Han, Chu, Qingpo, Xu, Feilong, Li, Yuan, Chen, Ruonan, Shen, Chunyan, Schinckel, Allan P
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Untranslated regions Animals Attenuation Autoantigens - genetics Bioinformatics Cell Differentiation - genetics Cell Differentiation - physiology Cell Line Cell proliferation Cell Proliferation - genetics Cell Proliferation - physiology Differentiation Gene Expression Regulation, Developmental Gene Knockdown Techniques Hypertrophy Mice Mice, Inbred BALB C MicroRNAs - chemistry MicroRNAs - genetics MicroRNAs - metabolism Models, Biological mRNA Muscle Development - genetics Muscle Development - physiology Muscle, Skeletal - cytology Muscle, Skeletal - growth & development Muscle, Skeletal - metabolism Muscles Musculoskeletal system Myoblasts Myoblasts, Skeletal - cytology Myoblasts, Skeletal - metabolism Myogenesis Ribonucleic acid RNA RNA, Long Noncoding - chemistry RNA, Long Noncoding - genetics RNA, Long Noncoding - metabolism Skeletal muscle
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