lncRNA AK017368 promotes proliferation and suppresses differentiation of myoblasts in skeletal muscle development by attenuating the function of miR-30c
Long noncoding RNAs (lncRNAs) have been reported to play diverse roles in biologic and pathologic processes, including myogenesis. We found that lncRNA is highly expressed in skeletal muscle cells. Functional analyses showed that overexpression of promoted proliferation and restrained differentiatio...
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| creator | Liang, Tingting Zhou, Bo Shi, Lei Wang, Han Chu, Qingpo Xu, Feilong Li, Yuan Chen, Ruonan Shen, Chunyan Schinckel, Allan P |
| description | Long noncoding RNAs (lncRNAs) have been reported to play diverse roles in biologic and pathologic processes, including myogenesis. We found that lncRNA
is highly expressed in skeletal muscle cells. Functional analyses showed that overexpression of
promoted proliferation and restrained differentiation of myoblasts; whereas inhibition of
had completely opposite effects
In mice, knockdown of
promoted muscle hypertrophy
RNA molecules of
acted mechanistically as competing endogenous RNAs to target micro-RNA (miR)-30c, which was supported by the results of bioinformatics analyses and dual-luciferase reporter assays. It has been shown that lncRNA
competes with trinucleotide repeat containing-6A (
) for miR-30c.
was previously reported to promote proliferation and inhibit differentiation of myoblast cells, whereas miR-30c targets the 3'-UTR of
mRNA to weaken its function. Taken together, lncRNA
promotes proliferation and inhibits differentiation of myoblast cells by attenuating function of miR-30c.-Liang, T., Zhou, B., Shi, L., Wang, H., Chu, Q., Xu, F., Li, Y., Chen, R., Shen, C., Schinckel, A. P. lncRNA
promotes proliferation and suppresses differentiation of myoblasts in skeletal muscle development by attenuating the function of miR-30c. |
| doi_str_mv | 10.1096/fj.201700560RR |
| format | Article |
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is highly expressed in skeletal muscle cells. Functional analyses showed that overexpression of
promoted proliferation and restrained differentiation of myoblasts; whereas inhibition of
had completely opposite effects
In mice, knockdown of
promoted muscle hypertrophy
RNA molecules of
acted mechanistically as competing endogenous RNAs to target micro-RNA (miR)-30c, which was supported by the results of bioinformatics analyses and dual-luciferase reporter assays. It has been shown that lncRNA
competes with trinucleotide repeat containing-6A (
) for miR-30c.
was previously reported to promote proliferation and inhibit differentiation of myoblast cells, whereas miR-30c targets the 3'-UTR of
mRNA to weaken its function. Taken together, lncRNA
promotes proliferation and inhibits differentiation of myoblast cells by attenuating function of miR-30c.-Liang, T., Zhou, B., Shi, L., Wang, H., Chu, Q., Xu, F., Li, Y., Chen, R., Shen, C., Schinckel, A. P. lncRNA
promotes proliferation and suppresses differentiation of myoblasts in skeletal muscle development by attenuating the function of miR-30c.</description><identifier>ISSN: 0892-6638</identifier><identifier>EISSN: 1530-6860</identifier><identifier>DOI: 10.1096/fj.201700560RR</identifier><identifier>PMID: 28904016</identifier><language>eng</language><publisher>United States: Federation of American Societies for Experimental Biology (FASEB)</publisher><subject>3' Untranslated regions ; Animals ; Attenuation ; Autoantigens - genetics ; Bioinformatics ; Cell Differentiation - genetics ; Cell Differentiation - physiology ; Cell Line ; Cell proliferation ; Cell Proliferation - genetics ; Cell Proliferation - physiology ; Differentiation ; Gene Expression Regulation, Developmental ; Gene Knockdown Techniques ; Hypertrophy ; Mice ; Mice, Inbred BALB C ; MicroRNAs - chemistry ; MicroRNAs - genetics ; MicroRNAs - metabolism ; Models, Biological ; mRNA ; Muscle Development - genetics ; Muscle Development - physiology ; Muscle, Skeletal - cytology ; Muscle, Skeletal - growth & development ; Muscle, Skeletal - metabolism ; Muscles ; Musculoskeletal system ; Myoblasts ; Myoblasts, Skeletal - cytology ; Myoblasts, Skeletal - metabolism ; Myogenesis ; Ribonucleic acid ; RNA ; RNA, Long Noncoding - chemistry ; RNA, Long Noncoding - genetics ; RNA, Long Noncoding - metabolism ; Skeletal muscle</subject><ispartof>The FASEB journal, 2018-01, Vol.32 (1), p.377-389</ispartof><rights>FASEB.</rights><rights>Copyright Federation of American Societies for Experimental Biology (FASEB) Jan 2018</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c251t-4b84335a5490c606964c5d4cd55570cbdbc8df61bd9e64c238962cbe9dd1b15f3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28904016$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liang, Tingting</creatorcontrib><creatorcontrib>Zhou, Bo</creatorcontrib><creatorcontrib>Shi, Lei</creatorcontrib><creatorcontrib>Wang, Han</creatorcontrib><creatorcontrib>Chu, Qingpo</creatorcontrib><creatorcontrib>Xu, Feilong</creatorcontrib><creatorcontrib>Li, Yuan</creatorcontrib><creatorcontrib>Chen, Ruonan</creatorcontrib><creatorcontrib>Shen, Chunyan</creatorcontrib><creatorcontrib>Schinckel, Allan P</creatorcontrib><title>lncRNA AK017368 promotes proliferation and suppresses differentiation of myoblasts in skeletal muscle development by attenuating the function of miR-30c</title><title>The FASEB journal</title><addtitle>FASEB J</addtitle><description>Long noncoding RNAs (lncRNAs) have been reported to play diverse roles in biologic and pathologic processes, including myogenesis. We found that lncRNA
is highly expressed in skeletal muscle cells. Functional analyses showed that overexpression of
promoted proliferation and restrained differentiation of myoblasts; whereas inhibition of
had completely opposite effects
In mice, knockdown of
promoted muscle hypertrophy
RNA molecules of
acted mechanistically as competing endogenous RNAs to target micro-RNA (miR)-30c, which was supported by the results of bioinformatics analyses and dual-luciferase reporter assays. It has been shown that lncRNA
competes with trinucleotide repeat containing-6A (
) for miR-30c.
was previously reported to promote proliferation and inhibit differentiation of myoblast cells, whereas miR-30c targets the 3'-UTR of
mRNA to weaken its function. Taken together, lncRNA
promotes proliferation and inhibits differentiation of myoblast cells by attenuating function of miR-30c.-Liang, T., Zhou, B., Shi, L., Wang, H., Chu, Q., Xu, F., Li, Y., Chen, R., Shen, C., Schinckel, A. P. lncRNA
promotes proliferation and suppresses differentiation of myoblasts in skeletal muscle development by attenuating the function of miR-30c.</description><subject>3' Untranslated regions</subject><subject>Animals</subject><subject>Attenuation</subject><subject>Autoantigens - genetics</subject><subject>Bioinformatics</subject><subject>Cell Differentiation - genetics</subject><subject>Cell Differentiation - physiology</subject><subject>Cell Line</subject><subject>Cell proliferation</subject><subject>Cell Proliferation - genetics</subject><subject>Cell Proliferation - physiology</subject><subject>Differentiation</subject><subject>Gene Expression Regulation, Developmental</subject><subject>Gene Knockdown Techniques</subject><subject>Hypertrophy</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>MicroRNAs - chemistry</subject><subject>MicroRNAs - genetics</subject><subject>MicroRNAs - metabolism</subject><subject>Models, Biological</subject><subject>mRNA</subject><subject>Muscle Development - genetics</subject><subject>Muscle Development - physiology</subject><subject>Muscle, Skeletal - cytology</subject><subject>Muscle, Skeletal - growth & development</subject><subject>Muscle, Skeletal - metabolism</subject><subject>Muscles</subject><subject>Musculoskeletal system</subject><subject>Myoblasts</subject><subject>Myoblasts, Skeletal - cytology</subject><subject>Myoblasts, Skeletal - metabolism</subject><subject>Myogenesis</subject><subject>Ribonucleic acid</subject><subject>RNA</subject><subject>RNA, Long Noncoding - chemistry</subject><subject>RNA, Long Noncoding - genetics</subject><subject>RNA, Long Noncoding - metabolism</subject><subject>Skeletal muscle</subject><issn>0892-6638</issn><issn>1530-6860</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kEtPwzAQhC0EoqVw5YgscQ6s49i1j1XFS1QgRXCu_AqkJE6IHaT-E34uRi2cdqRvZla7CJ0TuCIg-XW1ucqBzAEYh7I8QFPCKGRccDhEUxAyzzinYoJOQtgAAAHCj9EkFxKKJKfou_GmfFrgxWNqoVzgfujaLrrwK5q6coOKdeex8haHse8HF0KCtq4Scj7WO9xVuN12ulEhBlx7HD5c46JqcDsG0zhs3Zdrur5NCay3WMXo_Jii_g3Hd4er0Zv_nrrMKJhTdFSpJriz_Zyh19ubl-V9tnq-e1guVpnJGYlZoUVBKVOskGA4cMkLw2xhLGNsDkZbbYStONFWuoRyKiTPjXbSWqIJq-gMXe56072fowtxvenGwaeV6xyACyHpnCTXxd416tbZdT_UrRq2679H0h_k23c8</recordid><startdate>201801</startdate><enddate>201801</enddate><creator>Liang, Tingting</creator><creator>Zhou, Bo</creator><creator>Shi, Lei</creator><creator>Wang, Han</creator><creator>Chu, Qingpo</creator><creator>Xu, Feilong</creator><creator>Li, Yuan</creator><creator>Chen, Ruonan</creator><creator>Shen, Chunyan</creator><creator>Schinckel, Allan P</creator><general>Federation of American Societies for Experimental Biology (FASEB)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7QP</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope></search><sort><creationdate>201801</creationdate><title>lncRNA AK017368 promotes proliferation and suppresses differentiation of myoblasts in skeletal muscle development by attenuating the function of miR-30c</title><author>Liang, Tingting ; Zhou, Bo ; Shi, Lei ; Wang, Han ; Chu, Qingpo ; Xu, Feilong ; Li, Yuan ; Chen, Ruonan ; Shen, Chunyan ; Schinckel, Allan P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c251t-4b84335a5490c606964c5d4cd55570cbdbc8df61bd9e64c238962cbe9dd1b15f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>3' Untranslated regions</topic><topic>Animals</topic><topic>Attenuation</topic><topic>Autoantigens - genetics</topic><topic>Bioinformatics</topic><topic>Cell Differentiation - genetics</topic><topic>Cell Differentiation - physiology</topic><topic>Cell Line</topic><topic>Cell proliferation</topic><topic>Cell Proliferation - genetics</topic><topic>Cell Proliferation - physiology</topic><topic>Differentiation</topic><topic>Gene Expression Regulation, Developmental</topic><topic>Gene Knockdown Techniques</topic><topic>Hypertrophy</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>MicroRNAs - chemistry</topic><topic>MicroRNAs - genetics</topic><topic>MicroRNAs - metabolism</topic><topic>Models, Biological</topic><topic>mRNA</topic><topic>Muscle Development - genetics</topic><topic>Muscle Development - physiology</topic><topic>Muscle, Skeletal - cytology</topic><topic>Muscle, Skeletal - growth & development</topic><topic>Muscle, Skeletal - metabolism</topic><topic>Muscles</topic><topic>Musculoskeletal system</topic><topic>Myoblasts</topic><topic>Myoblasts, Skeletal - cytology</topic><topic>Myoblasts, Skeletal - metabolism</topic><topic>Myogenesis</topic><topic>Ribonucleic acid</topic><topic>RNA</topic><topic>RNA, Long Noncoding - chemistry</topic><topic>RNA, Long Noncoding - genetics</topic><topic>RNA, Long Noncoding - metabolism</topic><topic>Skeletal muscle</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liang, Tingting</creatorcontrib><creatorcontrib>Zhou, Bo</creatorcontrib><creatorcontrib>Shi, Lei</creatorcontrib><creatorcontrib>Wang, Han</creatorcontrib><creatorcontrib>Chu, Qingpo</creatorcontrib><creatorcontrib>Xu, Feilong</creatorcontrib><creatorcontrib>Li, Yuan</creatorcontrib><creatorcontrib>Chen, Ruonan</creatorcontrib><creatorcontrib>Shen, Chunyan</creatorcontrib><creatorcontrib>Schinckel, Allan P</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><jtitle>The FASEB journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liang, Tingting</au><au>Zhou, Bo</au><au>Shi, Lei</au><au>Wang, Han</au><au>Chu, Qingpo</au><au>Xu, Feilong</au><au>Li, Yuan</au><au>Chen, Ruonan</au><au>Shen, Chunyan</au><au>Schinckel, Allan P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>lncRNA AK017368 promotes proliferation and suppresses differentiation of myoblasts in skeletal muscle development by attenuating the function of miR-30c</atitle><jtitle>The FASEB journal</jtitle><addtitle>FASEB J</addtitle><date>2018-01</date><risdate>2018</risdate><volume>32</volume><issue>1</issue><spage>377</spage><epage>389</epage><pages>377-389</pages><issn>0892-6638</issn><eissn>1530-6860</eissn><abstract>Long noncoding RNAs (lncRNAs) have been reported to play diverse roles in biologic and pathologic processes, including myogenesis. We found that lncRNA
is highly expressed in skeletal muscle cells. Functional analyses showed that overexpression of
promoted proliferation and restrained differentiation of myoblasts; whereas inhibition of
had completely opposite effects
In mice, knockdown of
promoted muscle hypertrophy
RNA molecules of
acted mechanistically as competing endogenous RNAs to target micro-RNA (miR)-30c, which was supported by the results of bioinformatics analyses and dual-luciferase reporter assays. It has been shown that lncRNA
competes with trinucleotide repeat containing-6A (
) for miR-30c.
was previously reported to promote proliferation and inhibit differentiation of myoblast cells, whereas miR-30c targets the 3'-UTR of
mRNA to weaken its function. Taken together, lncRNA
promotes proliferation and inhibits differentiation of myoblast cells by attenuating function of miR-30c.-Liang, T., Zhou, B., Shi, L., Wang, H., Chu, Q., Xu, F., Li, Y., Chen, R., Shen, C., Schinckel, A. P. lncRNA
promotes proliferation and suppresses differentiation of myoblasts in skeletal muscle development by attenuating the function of miR-30c.</abstract><cop>United States</cop><pub>Federation of American Societies for Experimental Biology (FASEB)</pub><pmid>28904016</pmid><doi>10.1096/fj.201700560RR</doi><tpages>13</tpages></addata></record> |
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| identifier | ISSN: 0892-6638 |
| ispartof | The FASEB journal, 2018-01, Vol.32 (1), p.377-389 |
| issn | 0892-6638 1530-6860 |
| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Alma/SFX Local Collection |
| subjects | 3' Untranslated regions Animals Attenuation Autoantigens - genetics Bioinformatics Cell Differentiation - genetics Cell Differentiation - physiology Cell Line Cell proliferation Cell Proliferation - genetics Cell Proliferation - physiology Differentiation Gene Expression Regulation, Developmental Gene Knockdown Techniques Hypertrophy Mice Mice, Inbred BALB C MicroRNAs - chemistry MicroRNAs - genetics MicroRNAs - metabolism Models, Biological mRNA Muscle Development - genetics Muscle Development - physiology Muscle, Skeletal - cytology Muscle, Skeletal - growth & development Muscle, Skeletal - metabolism Muscles Musculoskeletal system Myoblasts Myoblasts, Skeletal - cytology Myoblasts, Skeletal - metabolism Myogenesis Ribonucleic acid RNA RNA, Long Noncoding - chemistry RNA, Long Noncoding - genetics RNA, Long Noncoding - metabolism Skeletal muscle |
| title | lncRNA AK017368 promotes proliferation and suppresses differentiation of myoblasts in skeletal muscle development by attenuating the function of miR-30c |
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