Calmodulin kinase II-mediated sarcoplasmic reticulum Ca^sup 2+^ leak promotes atrial fibrillation in mice

A trial fibrillation (AF), the most common human cardiac arrhythmia, is associated with abnormal intracellular Ca2+ handling. Diastolic Ca2+ release from the sarcoplasmic reticulum via "leaky" ryanodine receptors (RyR2s) is hypothesized to contribute to arrhythmogenesis in AF, but the mole...

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Veröffentlicht in:	The Journal of clinical investigation 2009-07, Vol.119 (7), p.1940
Hauptverfasser:	Chelu, Mihail G, Sarma, Satyam, Sood, Subeena, Wang, Sufen, van Oort, Ralph J, Skapura, Darlene G, Li, Na, Santonastasi, Marco, Müller, Frank Ulrich, Schmitz, Wilhelm, Schotten, Ulrich, Anderson, Mark E, Valderrábano, Miguel, Dobrev, Dobromir, Wehrens, Xander H T
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomedical research Biopsy Cardiac arrhythmia Cardiovascular disease Heart Kinases Mutation Pathogenesis Phosphorylation Proteins Sinuses
Online-Zugang:	Volltext
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