Phosphorylation of GSK-3[beta] by cGMP-dependent protein kinase II promotes hypertrophic differentiation of murine chondrocytes

cGMP-dependent protein kinase II (cGKII; encoded by PRKG2) is a serine/threonine kinase that is critical for skeletal growth in mammals; in mice, cGKII deficiency results in dwarfism. Using radiographic analysis, we determined that this growth defect was a consequence of an elongated growth plate an...

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Veröffentlicht in:	The Journal of clinical investigation 2008-07, Vol.118 (7), p.2506
Hauptverfasser:	Kawasaki, Yosuke, Kugimiya, Fumitaka, Chikuda, Hirotaka, Kamekura, Satoru, Ikeda, Toshiyuki, Kawamura, Naohiro, Saito, Taku, Shinoda, Yusuke, Higashikawa, Akiro, Yano, Fumiko, Ogasawara, Toru, Ogata, Naoshi, Hoshi, Kazuto, Hofmann, Franz, Woodgett, James R, Nakamura, Kozo, Chung, Ung-il, Kawaguchi, Hiroshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomedical research Cartilage Cell division Dwarfism Genes Kinases Peptides Phosphorylation Proteins Vertebrae
Online-Zugang:	Volltext
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