The unfolded protein response sensor IRE1[alpha] is required at 2 distinct steps in B cell lymphopoiesis

B lymphocyte differentiation is coordinated with the induction of high-level Ig secretion and expansion of the secretory pathway. Upon accumulation of unfolded proteins in the lumen of the ER, cells activate an intracellular signaling pathway termed the unfolded protein response (UPR). Two major pro...

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Veröffentlicht in:	The Journal of clinical investigation 2005-02, Vol.115 (2), p.268
Hauptverfasser:	Zhang, Kezhong, Wong, Hetty N, Song, Benbo, Miller, Corey N
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomedical research Bone marrow Cells Embryos Enzymes Genes Homeostasis Kinases Plasma Protein synthesis Proteins Sensors Signal transduction Transcription factors
Online-Zugang:	Volltext
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