Cadmium Accumulation and Detoxification by Alveolar Macrophages of Cigarette Smokers
Cadmium (Cd) is a toxic metal associated with emphysema and lung cancer, which is present in both air pollution and cigarette smoke. Metallothionein (MT) is an inducible protein that binds and detoxifies cellular Cd. The goals of this study were to determine whether increased concentrations of Cd ar...
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| Veröffentlicht in: | Chest 2003-11, Vol.124 (5), p.1924-1928 |
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| container_end_page | 1928 |
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| container_issue | 5 |
| container_start_page | 1924 |
| container_title | Chest |
| container_volume | 124 |
| creator | Grasseschi, Robert M. Ramaswamy, Rajanna B. Levine, Deborah J. Klaassen, Curtis D. Wesselius, Lewis J. |
| description | Cadmium (Cd) is a toxic metal associated with emphysema and lung cancer, which is present in both air pollution and cigarette smoke. Metallothionein (MT) is an inducible protein that binds and detoxifies cellular Cd. The goals of this study were to determine whether increased concentrations of Cd are present in alveolar macrophages (AMs) of cigarette smokers (CSMs) and to determine whether MT accumulated in response to the presence of Cd.
AMs were recovered by BAL from 10 healthy nonsmokers (NSMs) and 10 CSMs. The Cd content of the AMs was determined by inductively coupled plasma-mass spectrometry, and the MT content was determined using a Cd/hemoglobin radioassay (with 109Cd).
Cd was detected in AMs recovered from all subjects, with higher mean (± SEM) concentrations in CSMs compared with those in NSMs (3.4 ± 0.5 vs 1.3 ± 0.2 ng/106 cells; p < 0.005). There was a correlation between current smoking history (cigarettes per day) and the AM content of Cd (r = 0.74; p < 0.05). The mean AM content of MT was similar in NSMs (1.2 ± 0.2 μg/107 cells) and CSMs (1.0 ± 0.2 μg/107 cells).
AMs in CSMs accumulate significant amounts of Cd without a concurrent increase in MT content, indicating greater saturation of MT. Increased Cd burden in alveolar cells could contribute to the development of lung diseases in CSMs. |
| doi_str_mv | 10.1378/chest.124.5.1924 |
| format | Article |
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AMs were recovered by BAL from 10 healthy nonsmokers (NSMs) and 10 CSMs. The Cd content of the AMs was determined by inductively coupled plasma-mass spectrometry, and the MT content was determined using a Cd/hemoglobin radioassay (with 109Cd).
Cd was detected in AMs recovered from all subjects, with higher mean (± SEM) concentrations in CSMs compared with those in NSMs (3.4 ± 0.5 vs 1.3 ± 0.2 ng/106 cells; p < 0.005). There was a correlation between current smoking history (cigarettes per day) and the AM content of Cd (r = 0.74; p < 0.05). The mean AM content of MT was similar in NSMs (1.2 ± 0.2 μg/107 cells) and CSMs (1.0 ± 0.2 μg/107 cells).
AMs in CSMs accumulate significant amounts of Cd without a concurrent increase in MT content, indicating greater saturation of MT. Increased Cd burden in alveolar cells could contribute to the development of lung diseases in CSMs.</description><identifier>ISSN: 0012-3692</identifier><identifier>EISSN: 1931-3543</identifier><identifier>DOI: 10.1378/chest.124.5.1924</identifier><identifier>PMID: 14605069</identifier><identifier>CODEN: CHETBF</identifier><language>eng</language><publisher>Northbrook, IL: Elsevier Inc</publisher><subject>Air pollution ; alveolar macrophage ; Biological and medical sciences ; Bronchoalveolar Lavage Fluid - cytology ; Bronchoscopy ; Cadmium ; Cadmium - pharmacokinetics ; cigarette smoking ; Cigarettes ; Emphysema ; Hemoglobin ; Humans ; Inactivation, Metabolic ; Lung cancer ; Lung diseases ; Macrophages, Alveolar - metabolism ; Male ; Medical sciences ; metallothionein ; Metallothionein - metabolism ; Middle Aged ; Outdoor air quality ; Proteins ; Smoking ; Smoking - metabolism ; Smoking - pathology ; Tobacco, tobacco smoking ; Toxicity ; Toxicology</subject><ispartof>Chest, 2003-11, Vol.124 (5), p.1924-1928</ispartof><rights>2003 The American College of Chest Physicians</rights><rights>2004 INIST-CNRS</rights><rights>Copyright American College of Chest Physicians Nov 2003</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c444t-34f54b089583355ac56efe57d5136a58faf4da164d4f2e61f32059b557b5f5173</citedby><cites>FETCH-LOGICAL-c444t-34f54b089583355ac56efe57d5136a58faf4da164d4f2e61f32059b557b5f5173</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15288541$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14605069$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Grasseschi, Robert M.</creatorcontrib><creatorcontrib>Ramaswamy, Rajanna B.</creatorcontrib><creatorcontrib>Levine, Deborah J.</creatorcontrib><creatorcontrib>Klaassen, Curtis D.</creatorcontrib><creatorcontrib>Wesselius, Lewis J.</creatorcontrib><title>Cadmium Accumulation and Detoxification by Alveolar Macrophages of Cigarette Smokers</title><title>Chest</title><addtitle>Chest</addtitle><description>Cadmium (Cd) is a toxic metal associated with emphysema and lung cancer, which is present in both air pollution and cigarette smoke. Metallothionein (MT) is an inducible protein that binds and detoxifies cellular Cd. The goals of this study were to determine whether increased concentrations of Cd are present in alveolar macrophages (AMs) of cigarette smokers (CSMs) and to determine whether MT accumulated in response to the presence of Cd.
AMs were recovered by BAL from 10 healthy nonsmokers (NSMs) and 10 CSMs. The Cd content of the AMs was determined by inductively coupled plasma-mass spectrometry, and the MT content was determined using a Cd/hemoglobin radioassay (with 109Cd).
Cd was detected in AMs recovered from all subjects, with higher mean (± SEM) concentrations in CSMs compared with those in NSMs (3.4 ± 0.5 vs 1.3 ± 0.2 ng/106 cells; p < 0.005). There was a correlation between current smoking history (cigarettes per day) and the AM content of Cd (r = 0.74; p < 0.05). The mean AM content of MT was similar in NSMs (1.2 ± 0.2 μg/107 cells) and CSMs (1.0 ± 0.2 μg/107 cells).
AMs in CSMs accumulate significant amounts of Cd without a concurrent increase in MT content, indicating greater saturation of MT. Increased Cd burden in alveolar cells could contribute to the development of lung diseases in CSMs.</description><subject>Air pollution</subject><subject>alveolar macrophage</subject><subject>Biological and medical sciences</subject><subject>Bronchoalveolar Lavage Fluid - cytology</subject><subject>Bronchoscopy</subject><subject>Cadmium</subject><subject>Cadmium - pharmacokinetics</subject><subject>cigarette smoking</subject><subject>Cigarettes</subject><subject>Emphysema</subject><subject>Hemoglobin</subject><subject>Humans</subject><subject>Inactivation, Metabolic</subject><subject>Lung cancer</subject><subject>Lung diseases</subject><subject>Macrophages, Alveolar - metabolism</subject><subject>Male</subject><subject>Medical sciences</subject><subject>metallothionein</subject><subject>Metallothionein - metabolism</subject><subject>Middle Aged</subject><subject>Outdoor air quality</subject><subject>Proteins</subject><subject>Smoking</subject><subject>Smoking - metabolism</subject><subject>Smoking - pathology</subject><subject>Tobacco, tobacco smoking</subject><subject>Toxicity</subject><subject>Toxicology</subject><issn>0012-3692</issn><issn>1931-3543</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kE1v1DAQhi0EokvhzglFSByztWNPNuG22vJRqYgD5WxNnPGuSxIvdlLov8clkVY99GSN9X7pYeyt4GshN9WFOVAc16JQa1iLulDP2ErUUuQSlHzOVpyLIpdlXZyxVzHe8nSLunzJzoQqOfCyXrGbHba9m_psa8zUTx2Ozg8ZDm12SaP_66wz81dzn227O_IdhuwbmuCPB9xTzLzNdm6PgcaRsh-9_0UhvmYvLHaR3izvOfv5-dPN7mt-_f3L1W57nRul1JhLZUE1vKqhkhIADZRkCTYtCFkiVBatalGUqlW2oFJYWXCoG4BNAxbERp6z93PuMfjfU0Khb_0UhlSpC85B8grqJOKzKG2OMZDVx-B6DPdacP1AUf-nqBNFDfqBYrK8W3Knpqf2ZFiwJcGHRYDRYGcDDsbFkw6KqgIlTt0Htz_8cYF07LHrUqycW5e9j7o_zhZK4O4cBR2No8FQm-xm1K13Tw__ByVin-8</recordid><startdate>20031101</startdate><enddate>20031101</enddate><creator>Grasseschi, Robert M.</creator><creator>Ramaswamy, Rajanna B.</creator><creator>Levine, Deborah J.</creator><creator>Klaassen, Curtis D.</creator><creator>Wesselius, Lewis J.</creator><general>Elsevier Inc</general><general>American College of Chest Physicians</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>20031101</creationdate><title>Cadmium Accumulation and Detoxification by Alveolar Macrophages of Cigarette Smokers</title><author>Grasseschi, Robert M. ; Ramaswamy, Rajanna B. ; Levine, Deborah J. ; Klaassen, Curtis D. ; Wesselius, Lewis J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c444t-34f54b089583355ac56efe57d5136a58faf4da164d4f2e61f32059b557b5f5173</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Air pollution</topic><topic>alveolar macrophage</topic><topic>Biological and medical sciences</topic><topic>Bronchoalveolar Lavage Fluid - cytology</topic><topic>Bronchoscopy</topic><topic>Cadmium</topic><topic>Cadmium - pharmacokinetics</topic><topic>cigarette smoking</topic><topic>Cigarettes</topic><topic>Emphysema</topic><topic>Hemoglobin</topic><topic>Humans</topic><topic>Inactivation, Metabolic</topic><topic>Lung cancer</topic><topic>Lung diseases</topic><topic>Macrophages, Alveolar - metabolism</topic><topic>Male</topic><topic>Medical sciences</topic><topic>metallothionein</topic><topic>Metallothionein - metabolism</topic><topic>Middle Aged</topic><topic>Outdoor air quality</topic><topic>Proteins</topic><topic>Smoking</topic><topic>Smoking - metabolism</topic><topic>Smoking - pathology</topic><topic>Tobacco, tobacco smoking</topic><topic>Toxicity</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Grasseschi, Robert M.</creatorcontrib><creatorcontrib>Ramaswamy, Rajanna B.</creatorcontrib><creatorcontrib>Levine, Deborah J.</creatorcontrib><creatorcontrib>Klaassen, Curtis D.</creatorcontrib><creatorcontrib>Wesselius, Lewis J.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>Chest</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Grasseschi, Robert M.</au><au>Ramaswamy, Rajanna B.</au><au>Levine, Deborah J.</au><au>Klaassen, Curtis D.</au><au>Wesselius, Lewis J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cadmium Accumulation and Detoxification by Alveolar Macrophages of Cigarette Smokers</atitle><jtitle>Chest</jtitle><addtitle>Chest</addtitle><date>2003-11-01</date><risdate>2003</risdate><volume>124</volume><issue>5</issue><spage>1924</spage><epage>1928</epage><pages>1924-1928</pages><issn>0012-3692</issn><eissn>1931-3543</eissn><coden>CHETBF</coden><abstract>Cadmium (Cd) is a toxic metal associated with emphysema and lung cancer, which is present in both air pollution and cigarette smoke. Metallothionein (MT) is an inducible protein that binds and detoxifies cellular Cd. The goals of this study were to determine whether increased concentrations of Cd are present in alveolar macrophages (AMs) of cigarette smokers (CSMs) and to determine whether MT accumulated in response to the presence of Cd.
AMs were recovered by BAL from 10 healthy nonsmokers (NSMs) and 10 CSMs. The Cd content of the AMs was determined by inductively coupled plasma-mass spectrometry, and the MT content was determined using a Cd/hemoglobin radioassay (with 109Cd).
Cd was detected in AMs recovered from all subjects, with higher mean (± SEM) concentrations in CSMs compared with those in NSMs (3.4 ± 0.5 vs 1.3 ± 0.2 ng/106 cells; p < 0.005). There was a correlation between current smoking history (cigarettes per day) and the AM content of Cd (r = 0.74; p < 0.05). The mean AM content of MT was similar in NSMs (1.2 ± 0.2 μg/107 cells) and CSMs (1.0 ± 0.2 μg/107 cells).
AMs in CSMs accumulate significant amounts of Cd without a concurrent increase in MT content, indicating greater saturation of MT. Increased Cd burden in alveolar cells could contribute to the development of lung diseases in CSMs.</abstract><cop>Northbrook, IL</cop><pub>Elsevier Inc</pub><pmid>14605069</pmid><doi>10.1378/chest.124.5.1924</doi><tpages>5</tpages></addata></record> |
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| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Air pollution alveolar macrophage Biological and medical sciences Bronchoalveolar Lavage Fluid - cytology Bronchoscopy Cadmium Cadmium - pharmacokinetics cigarette smoking Cigarettes Emphysema Hemoglobin Humans Inactivation, Metabolic Lung cancer Lung diseases Macrophages, Alveolar - metabolism Male Medical sciences metallothionein Metallothionein - metabolism Middle Aged Outdoor air quality Proteins Smoking Smoking - metabolism Smoking - pathology Tobacco, tobacco smoking Toxicity Toxicology |
| title | Cadmium Accumulation and Detoxification by Alveolar Macrophages of Cigarette Smokers |
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