Early extubation following coronary artery bypass surgery : A Prospective randomized controlled trial
STUDY OBJECTIVES: To determine the safety of early extubation (EE) after coronary artery surgery. DESIGN: Prospective randomized controlled trial. SETTING: The cardiac surgery operating room and ICU of a university-affiliated teaching hospital. PATIENTS: One hundred eligible patients presenting for...
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| Veröffentlicht in: | Chest 1998-06, Vol.113 (6), p.1481-1488 |
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| container_title | Chest |
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| creator | SILBERT, B. S SANTAMARIA, J. D O'BRIEN, J. L BLYTH, C. M KELLY, W. J MOLNAR, R. R |
| description | STUDY OBJECTIVES: To determine the safety of early extubation (EE) after coronary artery surgery. DESIGN: Prospective randomized controlled trial. SETTING: The cardiac surgery operating room and ICU of a university-affiliated teaching hospital. PATIENTS: One hundred eligible patients presenting for elective coronary artery surgery. INTERVENTIONS: Patients randomized to the EE group were administered a reduced dose of fentanyl (15 microg/kg) and an anesthetic compatible with EE, while patients randomized to the conventional extubation (CE) group were given fentanyl (50 microg/kg). MEASUREMENTS AND RESULTS: The time to extubation in the EE group (median, 240 min; range, 30 to 930 min) was significantly less than the CE group (median, 420 min; range, 125 to 1,140 min) (p |
| doi_str_mv | 10.1378/chest.113.6.1481 |
| format | Article |
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S ; SANTAMARIA, J. D ; O'BRIEN, J. L ; BLYTH, C. M ; KELLY, W. J ; MOLNAR, R. R</creator><creatorcontrib>SILBERT, B. S ; SANTAMARIA, J. D ; O'BRIEN, J. L ; BLYTH, C. M ; KELLY, W. J ; MOLNAR, R. R</creatorcontrib><description>STUDY OBJECTIVES: To determine the safety of early extubation (EE) after coronary artery surgery. DESIGN: Prospective randomized controlled trial. SETTING: The cardiac surgery operating room and ICU of a university-affiliated teaching hospital. PATIENTS: One hundred eligible patients presenting for elective coronary artery surgery. INTERVENTIONS: Patients randomized to the EE group were administered a reduced dose of fentanyl (15 microg/kg) and an anesthetic compatible with EE, while patients randomized to the conventional extubation (CE) group were given fentanyl (50 microg/kg). MEASUREMENTS AND RESULTS: The time to extubation in the EE group (median, 240 min; range, 30 to 930 min) was significantly less than the CE group (median, 420 min; range, 125 to 1,140 min) (p<0.01). Twenty patients were withdrawn from the study according to protocol guidelines. There were no cases of reintubation or complications attributable to EE. CONCLUSIONS: By using an appropriate anesthetic technique and postoperative management, EE can be achieved following coronary artery bypass surgery without major complications.</description><identifier>ISSN: 0012-3692</identifier><identifier>EISSN: 1931-3543</identifier><identifier>DOI: 10.1378/chest.113.6.1481</identifier><identifier>CODEN: CHETBF</identifier><language>eng</language><publisher>Northbrook, IL: American College of Chest Physicians</publisher><subject>Anesthesia ; Anesthesia depending on type of surgery ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Biological and medical sciences ; Medical sciences ; Thoracic and cardiovascular surgery. Cardiopulmonary bypass</subject><ispartof>Chest, 1998-06, Vol.113 (6), p.1481-1488</ispartof><rights>1998 INIST-CNRS</rights><rights>Copyright American College of Chest Physicians Jun 1998</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2275363$$DView record in Pascal Francis$$Hfree_for_read</backlink></links><search><creatorcontrib>SILBERT, B. S</creatorcontrib><creatorcontrib>SANTAMARIA, J. D</creatorcontrib><creatorcontrib>O'BRIEN, J. L</creatorcontrib><creatorcontrib>BLYTH, C. M</creatorcontrib><creatorcontrib>KELLY, W. J</creatorcontrib><creatorcontrib>MOLNAR, R. R</creatorcontrib><title>Early extubation following coronary artery bypass surgery : A Prospective randomized controlled trial</title><title>Chest</title><description>STUDY OBJECTIVES: To determine the safety of early extubation (EE) after coronary artery surgery. DESIGN: Prospective randomized controlled trial. SETTING: The cardiac surgery operating room and ICU of a university-affiliated teaching hospital. PATIENTS: One hundred eligible patients presenting for elective coronary artery surgery. INTERVENTIONS: Patients randomized to the EE group were administered a reduced dose of fentanyl (15 microg/kg) and an anesthetic compatible with EE, while patients randomized to the conventional extubation (CE) group were given fentanyl (50 microg/kg). MEASUREMENTS AND RESULTS: The time to extubation in the EE group (median, 240 min; range, 30 to 930 min) was significantly less than the CE group (median, 420 min; range, 125 to 1,140 min) (p<0.01). Twenty patients were withdrawn from the study according to protocol guidelines. There were no cases of reintubation or complications attributable to EE. CONCLUSIONS: By using an appropriate anesthetic technique and postoperative management, EE can be achieved following coronary artery bypass surgery without major complications.</description><subject>Anesthesia</subject><subject>Anesthesia depending on type of surgery</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Biological and medical sciences</subject><subject>Medical sciences</subject><subject>Thoracic and cardiovascular surgery. 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R</creator><general>American College of Chest Physicians</general><scope>IQODW</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>19980601</creationdate><title>Early extubation following coronary artery bypass surgery : A Prospective randomized controlled trial</title><author>SILBERT, B. S ; SANTAMARIA, J. D ; O'BRIEN, J. L ; BLYTH, C. M ; KELLY, W. J ; MOLNAR, R. R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p209t-b1426380617c51c293e4958452a379608c809d5c33bd5a78a45eefc0deeaa84a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Anesthesia</topic><topic>Anesthesia depending on type of surgery</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Biological and medical sciences</topic><topic>Medical sciences</topic><topic>Thoracic and cardiovascular surgery. Cardiopulmonary bypass</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>SILBERT, B. S</creatorcontrib><creatorcontrib>SANTAMARIA, J. D</creatorcontrib><creatorcontrib>O'BRIEN, J. L</creatorcontrib><creatorcontrib>BLYTH, C. M</creatorcontrib><creatorcontrib>KELLY, W. J</creatorcontrib><creatorcontrib>MOLNAR, R. 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S</au><au>SANTAMARIA, J. D</au><au>O'BRIEN, J. L</au><au>BLYTH, C. M</au><au>KELLY, W. J</au><au>MOLNAR, R. R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Early extubation following coronary artery bypass surgery : A Prospective randomized controlled trial</atitle><jtitle>Chest</jtitle><date>1998-06-01</date><risdate>1998</risdate><volume>113</volume><issue>6</issue><spage>1481</spage><epage>1488</epage><pages>1481-1488</pages><issn>0012-3692</issn><eissn>1931-3543</eissn><coden>CHETBF</coden><abstract>STUDY OBJECTIVES: To determine the safety of early extubation (EE) after coronary artery surgery. DESIGN: Prospective randomized controlled trial. SETTING: The cardiac surgery operating room and ICU of a university-affiliated teaching hospital. PATIENTS: One hundred eligible patients presenting for elective coronary artery surgery. INTERVENTIONS: Patients randomized to the EE group were administered a reduced dose of fentanyl (15 microg/kg) and an anesthetic compatible with EE, while patients randomized to the conventional extubation (CE) group were given fentanyl (50 microg/kg). MEASUREMENTS AND RESULTS: The time to extubation in the EE group (median, 240 min; range, 30 to 930 min) was significantly less than the CE group (median, 420 min; range, 125 to 1,140 min) (p<0.01). Twenty patients were withdrawn from the study according to protocol guidelines. There were no cases of reintubation or complications attributable to EE. CONCLUSIONS: By using an appropriate anesthetic technique and postoperative management, EE can be achieved following coronary artery bypass surgery without major complications.</abstract><cop>Northbrook, IL</cop><pub>American College of Chest Physicians</pub><doi>10.1378/chest.113.6.1481</doi><tpages>8</tpages></addata></record> |
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| ispartof | Chest, 1998-06, Vol.113 (6), p.1481-1488 |
| issn | 0012-3692 1931-3543 |
| language | eng |
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| source | Alma/SFX Local Collection |
| subjects | Anesthesia Anesthesia depending on type of surgery Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Medical sciences Thoracic and cardiovascular surgery. Cardiopulmonary bypass |
| title | Early extubation following coronary artery bypass surgery : A Prospective randomized controlled trial |
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