Outcomes after Angiography with Sodium Bicarbonate and Acetylcysteine

Among high-risk patients undergoing angiography, there was no benefit of intravenous sodium bicarbonate over sodium chloride or of oral acetylcysteine over placebo for the prevention of death, dialysis, or contrast-associated acute kidney injury.

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Bibliographische Detailangaben
Veröffentlicht in:	The New England journal of medicine 2018-02, Vol.378 (7), p.603-614
Hauptverfasser:	Weisbord, Steven D, Gallagher, Martin, Jneid, Hani, Garcia, Santiago, Cass, Alan, Thwin, Soe-Soe, Conner, Todd A, Chertow, Glenn M, Bhatt, Deepak L, Shunk, Kendrick, Parikh, Chirag R, McFalls, Edward O, Brophy, Mary, Ferguson, Ryan, Wu, Hongsheng, Androsenko, Maria, Myles, John, Kaufman, James, Palevsky, Paul M
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcysteine Acetylcysteine - therapeutic use Acute Kidney Injury - chemically induced Acute Kidney Injury - prevention & control Administration, Oral Aged Angiography Angiography - adverse effects Bicarbonates Chloride Clinical outcomes Contrast Media - adverse effects Creatinine Creatinine - blood Dialysis Double-Blind Method Female Fluid Therapy Humans Infusions, Intravenous Intervention Intravenous administration Kidneys Male Medical imaging Medical research Middle Aged Patients Prevention Renal Dialysis Renal Insufficiency, Chronic - therapy Risk Factors Sodium bicarbonate Sodium Bicarbonate - therapeutic use Sodium chloride Sodium Chloride - therapeutic use Treatment Outcome
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Beschreibung
Zusammenfassung:	Among high-risk patients undergoing angiography, there was no benefit of intravenous sodium bicarbonate over sodium chloride or of oral acetylcysteine over placebo for the prevention of death, dialysis, or contrast-associated acute kidney injury.
ISSN:	0028-4793 1533-4406
DOI:	10.1056/NEJMoa1710933