Cisplatin-induced human peripheral blood mononuclear cells’ oxidative stress and nephrotoxicity in head and neck cancer patients: the influence of hydrogen peroxide
Cisplatin is a widely used antineoplastic agent in the treatment of head and neck cancer. However, it is highly nephrotoxic. Oxidative stress is the main mechanism responsible for cisplatin-induced nephrotoxicity. The aim of this study was to characterize cisplatin-induced nephrotoxicity, oxidative...
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| Veröffentlicht in: | Molecular and cellular biochemistry 2018-03, Vol.440 (1-2), p.139-145 |
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| creator | Quintanilha, Júlia C. F. Visacri, Marília B. Sousa, Vanessa M. Bastos, Larissa B. Vaz, Camila O. Guarnieri, João P. O. Amaral, Laís S. Malaguti, Carina Lima, Carmen S. P. Vercesi, Anibal E. Moriel, Patricia |
| description | Cisplatin is a widely used antineoplastic agent in the treatment of head and neck cancer. However, it is highly nephrotoxic. Oxidative stress is the main mechanism responsible for cisplatin-induced nephrotoxicity. The aim of this study was to characterize cisplatin-induced nephrotoxicity, oxidative stress in peripheral blood mononuclear cells, and the relationship between them. Twenty-four patients were included in the study. Patients had their blood collected prior to cisplatin administration, and 5 and 20 days after initiating therapy, to assess renal function and to determine oxidative stress with MitoSOX™Red, H
2
DCF-DA, and Amplex
®
Red tests. Renal function was assessed by measuring serum creatinine, creatinine clearance, and blood urea nitrogen (BUN). Serum creatinine and creatinine clearance were used to grade nephrotoxicity using Common Terminology Criteria for Adverse Events (CTCAE) v4.0. Compared to baseline values, the mean BUN and serum creatinine increased 135 and 100%, respectively, 5 days after cisplatin infusion. Mean creatinine clearance showed a 43% decrease compared to baseline value. Non-statistically significant changes in superoxide anion (O
2
•−
), hydrogen peroxide (H
2
O
2
), and general reactive oxygen species production occurred. A higher production of H
2
O
2
was correlated with variation in serum creatinine, and was associated with higher grades for serum creatinine increases and creatinine clearance reductions. Linear regression analyses showed an association between H
2
O
2
production and serum creatinine, creatinine clearance, and BUN levels. These results were observed for 5 days following cisplatin administration. In conclusion, H
2
O
2
production was significantly related to changes in all renal parameters that were evaluated, following the cisplatin infusion. |
| doi_str_mv | 10.1007/s11010-017-3162-2 |
| format | Article |
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2
DCF-DA, and Amplex
®
Red tests. Renal function was assessed by measuring serum creatinine, creatinine clearance, and blood urea nitrogen (BUN). Serum creatinine and creatinine clearance were used to grade nephrotoxicity using Common Terminology Criteria for Adverse Events (CTCAE) v4.0. Compared to baseline values, the mean BUN and serum creatinine increased 135 and 100%, respectively, 5 days after cisplatin infusion. Mean creatinine clearance showed a 43% decrease compared to baseline value. Non-statistically significant changes in superoxide anion (O
2
•−
), hydrogen peroxide (H
2
O
2
), and general reactive oxygen species production occurred. A higher production of H
2
O
2
was correlated with variation in serum creatinine, and was associated with higher grades for serum creatinine increases and creatinine clearance reductions. Linear regression analyses showed an association between H
2
O
2
production and serum creatinine, creatinine clearance, and BUN levels. These results were observed for 5 days following cisplatin administration. In conclusion, H
2
O
2
production was significantly related to changes in all renal parameters that were evaluated, following the cisplatin infusion.</description><identifier>ISSN: 0300-8177</identifier><identifier>EISSN: 1573-4919</identifier><identifier>DOI: 10.1007/s11010-017-3162-2</identifier><identifier>PMID: 28828710</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Biochemistry ; Biomedical and Life Sciences ; Blood ; Cancer ; Cardiology ; Chemotherapy ; Cisplatin ; Creatinine ; Head ; Head & neck cancer ; Hydrogen peroxide ; Leukocytes (mononuclear) ; Life Sciences ; Medical Biochemistry ; Nephrology ; Oncology ; Oxidative stress ; Patients ; Peripheral blood mononuclear cells ; Reactive oxygen species ; Regression analysis ; Renal function ; Statistical analysis ; Superoxide ; Terminology ; Toxicity ; Urea</subject><ispartof>Molecular and cellular biochemistry, 2018-03, Vol.440 (1-2), p.139-145</ispartof><rights>Springer Science+Business Media, LLC 2017</rights><rights>Molecular and Cellular Biochemistry is a copyright of Springer, (2017). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-a5e9e4c8a78f2163adf699e707f01283a62854d1419f950cfee2878a0372acbd3</citedby><cites>FETCH-LOGICAL-c372t-a5e9e4c8a78f2163adf699e707f01283a62854d1419f950cfee2878a0372acbd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11010-017-3162-2$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11010-017-3162-2$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28828710$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Quintanilha, Júlia C. F.</creatorcontrib><creatorcontrib>Visacri, Marília B.</creatorcontrib><creatorcontrib>Sousa, Vanessa M.</creatorcontrib><creatorcontrib>Bastos, Larissa B.</creatorcontrib><creatorcontrib>Vaz, Camila O.</creatorcontrib><creatorcontrib>Guarnieri, João P. O.</creatorcontrib><creatorcontrib>Amaral, Laís S.</creatorcontrib><creatorcontrib>Malaguti, Carina</creatorcontrib><creatorcontrib>Lima, Carmen S. P.</creatorcontrib><creatorcontrib>Vercesi, Anibal E.</creatorcontrib><creatorcontrib>Moriel, Patricia</creatorcontrib><title>Cisplatin-induced human peripheral blood mononuclear cells’ oxidative stress and nephrotoxicity in head and neck cancer patients: the influence of hydrogen peroxide</title><title>Molecular and cellular biochemistry</title><addtitle>Mol Cell Biochem</addtitle><addtitle>Mol Cell Biochem</addtitle><description>Cisplatin is a widely used antineoplastic agent in the treatment of head and neck cancer. However, it is highly nephrotoxic. Oxidative stress is the main mechanism responsible for cisplatin-induced nephrotoxicity. The aim of this study was to characterize cisplatin-induced nephrotoxicity, oxidative stress in peripheral blood mononuclear cells, and the relationship between them. Twenty-four patients were included in the study. Patients had their blood collected prior to cisplatin administration, and 5 and 20 days after initiating therapy, to assess renal function and to determine oxidative stress with MitoSOX™Red, H
2
DCF-DA, and Amplex
®
Red tests. Renal function was assessed by measuring serum creatinine, creatinine clearance, and blood urea nitrogen (BUN). Serum creatinine and creatinine clearance were used to grade nephrotoxicity using Common Terminology Criteria for Adverse Events (CTCAE) v4.0. Compared to baseline values, the mean BUN and serum creatinine increased 135 and 100%, respectively, 5 days after cisplatin infusion. Mean creatinine clearance showed a 43% decrease compared to baseline value. Non-statistically significant changes in superoxide anion (O
2
•−
), hydrogen peroxide (H
2
O
2
), and general reactive oxygen species production occurred. A higher production of H
2
O
2
was correlated with variation in serum creatinine, and was associated with higher grades for serum creatinine increases and creatinine clearance reductions. Linear regression analyses showed an association between H
2
O
2
production and serum creatinine, creatinine clearance, and BUN levels. These results were observed for 5 days following cisplatin administration. In conclusion, H
2
O
2
production was significantly related to changes in all renal parameters that were evaluated, following the cisplatin infusion.</description><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Blood</subject><subject>Cancer</subject><subject>Cardiology</subject><subject>Chemotherapy</subject><subject>Cisplatin</subject><subject>Creatinine</subject><subject>Head</subject><subject>Head & neck cancer</subject><subject>Hydrogen peroxide</subject><subject>Leukocytes (mononuclear)</subject><subject>Life Sciences</subject><subject>Medical Biochemistry</subject><subject>Nephrology</subject><subject>Oncology</subject><subject>Oxidative stress</subject><subject>Patients</subject><subject>Peripheral blood mononuclear cells</subject><subject>Reactive oxygen species</subject><subject>Regression analysis</subject><subject>Renal function</subject><subject>Statistical analysis</subject><subject>Superoxide</subject><subject>Terminology</subject><subject>Toxicity</subject><subject>Urea</subject><issn>0300-8177</issn><issn>1573-4919</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNp1kc1uEzEUhS0EomnhAdggS6xd7vUksYcdiviTKrGBteXY150pE3uwZxDZ8Rq8QB-sT4JDAl115cX5zjnWPYy9QLhEAPW6IAKCAFSiwbUU8hFb4Eo1Ytli-5gtoAEQGpU6Y-el3ECFAfEpO5NaS60QFux205dxsFMfRR_97Mjzbt7ZyEfK_dhRtgPfDil5vksxxdkNZDN3NAzl7tdvnn72vpp_EC9TplK4jZ5HGrucpqq5ftrzPvKOrD9J7ht3NjrKfKxGilN5w6eOKhWGmarAU-Dd3ud0TX9_caigZ-xJsEOh56f3gn19_-7L5qO4-vzh0-btlXCNkpOwK2pp6bRVOkhcN9aHdduSAhUApW7sWurV0uMS29CuwAWiegdtobqt2_rmgr065o45fZ-pTOYmzTnWSiMBJOqmopXCI-VyKiVTMGPudzbvDYI5LGOOy5i6jDksY2T1vDwlz9sd-f-Of1NUQB6BUqV4Tfm--uHUP--JnYA</recordid><startdate>20180301</startdate><enddate>20180301</enddate><creator>Quintanilha, Júlia C. 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F. ; Visacri, Marília B. ; Sousa, Vanessa M. ; Bastos, Larissa B. ; Vaz, Camila O. ; Guarnieri, João P. O. ; Amaral, Laís S. ; Malaguti, Carina ; Lima, Carmen S. 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F.</au><au>Visacri, Marília B.</au><au>Sousa, Vanessa M.</au><au>Bastos, Larissa B.</au><au>Vaz, Camila O.</au><au>Guarnieri, João P. O.</au><au>Amaral, Laís S.</au><au>Malaguti, Carina</au><au>Lima, Carmen S. P.</au><au>Vercesi, Anibal E.</au><au>Moriel, Patricia</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cisplatin-induced human peripheral blood mononuclear cells’ oxidative stress and nephrotoxicity in head and neck cancer patients: the influence of hydrogen peroxide</atitle><jtitle>Molecular and cellular biochemistry</jtitle><stitle>Mol Cell Biochem</stitle><addtitle>Mol Cell Biochem</addtitle><date>2018-03-01</date><risdate>2018</risdate><volume>440</volume><issue>1-2</issue><spage>139</spage><epage>145</epage><pages>139-145</pages><issn>0300-8177</issn><eissn>1573-4919</eissn><abstract>Cisplatin is a widely used antineoplastic agent in the treatment of head and neck cancer. However, it is highly nephrotoxic. Oxidative stress is the main mechanism responsible for cisplatin-induced nephrotoxicity. The aim of this study was to characterize cisplatin-induced nephrotoxicity, oxidative stress in peripheral blood mononuclear cells, and the relationship between them. Twenty-four patients were included in the study. Patients had their blood collected prior to cisplatin administration, and 5 and 20 days after initiating therapy, to assess renal function and to determine oxidative stress with MitoSOX™Red, H
2
DCF-DA, and Amplex
®
Red tests. Renal function was assessed by measuring serum creatinine, creatinine clearance, and blood urea nitrogen (BUN). Serum creatinine and creatinine clearance were used to grade nephrotoxicity using Common Terminology Criteria for Adverse Events (CTCAE) v4.0. Compared to baseline values, the mean BUN and serum creatinine increased 135 and 100%, respectively, 5 days after cisplatin infusion. Mean creatinine clearance showed a 43% decrease compared to baseline value. Non-statistically significant changes in superoxide anion (O
2
•−
), hydrogen peroxide (H
2
O
2
), and general reactive oxygen species production occurred. A higher production of H
2
O
2
was correlated with variation in serum creatinine, and was associated with higher grades for serum creatinine increases and creatinine clearance reductions. Linear regression analyses showed an association between H
2
O
2
production and serum creatinine, creatinine clearance, and BUN levels. These results were observed for 5 days following cisplatin administration. In conclusion, H
2
O
2
production was significantly related to changes in all renal parameters that were evaluated, following the cisplatin infusion.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>28828710</pmid><doi>10.1007/s11010-017-3162-2</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0300-8177 |
| ispartof | Molecular and cellular biochemistry, 2018-03, Vol.440 (1-2), p.139-145 |
| issn | 0300-8177 1573-4919 |
| language | eng |
| recordid | cdi_proquest_journals_2002183037 |
| source | SpringerLink Journals - AutoHoldings |
| subjects | Biochemistry Biomedical and Life Sciences Blood Cancer Cardiology Chemotherapy Cisplatin Creatinine Head Head & neck cancer Hydrogen peroxide Leukocytes (mononuclear) Life Sciences Medical Biochemistry Nephrology Oncology Oxidative stress Patients Peripheral blood mononuclear cells Reactive oxygen species Regression analysis Renal function Statistical analysis Superoxide Terminology Toxicity Urea |
| title | Cisplatin-induced human peripheral blood mononuclear cells’ oxidative stress and nephrotoxicity in head and neck cancer patients: the influence of hydrogen peroxide |
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