Making sense of antisense oligonucleotides: A narrative review

ABSTRACT Synthetic nucleic acid sequences that bind to ribonucleic acid (RNA) through Watson‐Crick base pairing are known as antisense oligonucleotides (ASOs) because they are complementary to “sense strand” nucleic acids. ASOs bind to selected sequences of RNA and regulate the expression of genes b...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Muscle & nerve 2018-03, Vol.57 (3), p.356-370
Hauptverfasser:	Goyal, Neelam, Narayanaswami, Pushpa
Format:	Artikel
Sprache:	eng
Schlagworte:	Amyloid Amyotrophic lateral sclerosis Antisense oligonucleotides Atrophy Chemical properties Clinical trials Duchenne muscular dystrophy Duchenne's muscular dystrophy Dystrophy eteplirsen Ethics Gene expression Gene sequencing Medical research Muscles Muscular dystrophy Neuromuscular diseases Nucleic acids nusinersen Oligonucleotides Pharmacology Polyneuropathy Proteins Ribonucleic acid RNA Spinal muscular atrophy Toxicity
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!