Electrospun Sandwich‐Structure Composite Membranes for Wound Dressing Scaffolds with High Antioxidant and Antibacterial Activity
In this study, the sandwich‐structured composite (SSC) membranes with well‐antibacterial and antioxidant properties, which have the promising application as wound dressing, are successfully fabricated by combining an electrospinning process. The SSC membranes are composed of three layers, including...
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| Veröffentlicht in: | Macromolecular materials and engineering 2018-02, Vol.303 (2), p.n/a |
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| container_title | Macromolecular materials and engineering |
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| creator | Li, Jinzhen Hu, Yang He, Ting Huang, Mengwen Zhang, Xiangchao Yuan, Jinying Wei, Yen Dong, Xianming Liu, Wei Ko, Frank Zhou, Wuyi |
| description | In this study, the sandwich‐structured composite (SSC) membranes with well‐antibacterial and antioxidant properties, which have the promising application as wound dressing, are successfully fabricated by combining an electrospinning process. The SSC membranes are composed of three layers, including the bottom polyvinylidene fluoride fibrous layer, the middle curcumin/polylactic acid (PLA) microsphere layer, and the top enrofloxacin/PLA fibrous layer, respectively. The obtained SSC membranes are characterized in terms of morphology, component, and mechanical property using scanning electronic microscope, X‐ray diffractometer, Fourier transform infrared spectroscopy, and universal electronic testing machine, respectively. Moreover, in vitro drug release, antioxidant activity, antimicrobial activity, and biocompatibility of the SSC membranes are also evaluated. The results showed that the obtained composite membranes indeed possess the sandwich structure, where the middle microsphere layer is located between two fibrous surface layers. It is found that the drug‐loaded SSC membranes show excellent antioxidant activity against •OH and DPPH free radicals and antibacterial activity against Staphylococcus aureus, Escherichia coli, Streptococcus pneumoniae, Pseudomonas aeruginosa, and Candida albicans. The combination of electrospinning and electrospraying opens up a new way to fabricate a variety of composite membranes with a sandwich structure, which have promising potential application as wound dressing scaffolds.
Sandwich‐structured composite (SSC) membranes are successfully fabricated by combining an electrospinning process. The prepared SSC membranes show a hydrophobic surface and a hydrophilic surface, and possess well antibacterial and antioxidant properties. This study demonstrates an innovative strategy for creating SSC membranes, which have promising application prospects as wound dressings. |
| doi_str_mv | 10.1002/mame.201700270 |
| format | Article |
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Sandwich‐structured composite (SSC) membranes are successfully fabricated by combining an electrospinning process. The prepared SSC membranes show a hydrophobic surface and a hydrophilic surface, and possess well antibacterial and antioxidant properties. This study demonstrates an innovative strategy for creating SSC membranes, which have promising application prospects as wound dressings.</description><identifier>ISSN: 1438-7492</identifier><identifier>EISSN: 1439-2054</identifier><identifier>DOI: 10.1002/mame.201700270</identifier><language>eng</language><publisher>Weinheim: John Wiley & Sons, Inc</publisher><subject>antibacterial and antioxidant assays ; Antioxidants ; Biocompatibility ; Drug delivery systems ; drug release ; E coli ; Electrospinning ; electrospun composite membrane ; Fourier transforms ; Free radicals ; Membranes ; Polylactic acid ; Polyvinylidene fluorides ; Pseudomonas aeruginosa ; Sandwich structures ; sandwich‐structure ; Scaffolds ; Streptococcus infections ; wound dressing ; Wound healing</subject><ispartof>Macromolecular materials and engineering, 2018-02, Vol.303 (2), p.n/a</ispartof><rights>2017 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim</rights><rights>2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3540-4aa71f98aa2b259b1022e80219a68cbe5b430bb5f615b975bbbbac48bcd70e9d3</citedby><cites>FETCH-LOGICAL-c3540-4aa71f98aa2b259b1022e80219a68cbe5b430bb5f615b975bbbbac48bcd70e9d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fmame.201700270$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fmame.201700270$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids></links><search><creatorcontrib>Li, Jinzhen</creatorcontrib><creatorcontrib>Hu, Yang</creatorcontrib><creatorcontrib>He, Ting</creatorcontrib><creatorcontrib>Huang, Mengwen</creatorcontrib><creatorcontrib>Zhang, Xiangchao</creatorcontrib><creatorcontrib>Yuan, Jinying</creatorcontrib><creatorcontrib>Wei, Yen</creatorcontrib><creatorcontrib>Dong, Xianming</creatorcontrib><creatorcontrib>Liu, Wei</creatorcontrib><creatorcontrib>Ko, Frank</creatorcontrib><creatorcontrib>Zhou, Wuyi</creatorcontrib><title>Electrospun Sandwich‐Structure Composite Membranes for Wound Dressing Scaffolds with High Antioxidant and Antibacterial Activity</title><title>Macromolecular materials and engineering</title><description>In this study, the sandwich‐structured composite (SSC) membranes with well‐antibacterial and antioxidant properties, which have the promising application as wound dressing, are successfully fabricated by combining an electrospinning process. The SSC membranes are composed of three layers, including the bottom polyvinylidene fluoride fibrous layer, the middle curcumin/polylactic acid (PLA) microsphere layer, and the top enrofloxacin/PLA fibrous layer, respectively. The obtained SSC membranes are characterized in terms of morphology, component, and mechanical property using scanning electronic microscope, X‐ray diffractometer, Fourier transform infrared spectroscopy, and universal electronic testing machine, respectively. Moreover, in vitro drug release, antioxidant activity, antimicrobial activity, and biocompatibility of the SSC membranes are also evaluated. The results showed that the obtained composite membranes indeed possess the sandwich structure, where the middle microsphere layer is located between two fibrous surface layers. It is found that the drug‐loaded SSC membranes show excellent antioxidant activity against •OH and DPPH free radicals and antibacterial activity against Staphylococcus aureus, Escherichia coli, Streptococcus pneumoniae, Pseudomonas aeruginosa, and Candida albicans. The combination of electrospinning and electrospraying opens up a new way to fabricate a variety of composite membranes with a sandwich structure, which have promising potential application as wound dressing scaffolds.
Sandwich‐structured composite (SSC) membranes are successfully fabricated by combining an electrospinning process. The prepared SSC membranes show a hydrophobic surface and a hydrophilic surface, and possess well antibacterial and antioxidant properties. This study demonstrates an innovative strategy for creating SSC membranes, which have promising application prospects as wound dressings.</description><subject>antibacterial and antioxidant assays</subject><subject>Antioxidants</subject><subject>Biocompatibility</subject><subject>Drug delivery systems</subject><subject>drug release</subject><subject>E coli</subject><subject>Electrospinning</subject><subject>electrospun composite membrane</subject><subject>Fourier transforms</subject><subject>Free radicals</subject><subject>Membranes</subject><subject>Polylactic acid</subject><subject>Polyvinylidene fluorides</subject><subject>Pseudomonas aeruginosa</subject><subject>Sandwich structures</subject><subject>sandwich‐structure</subject><subject>Scaffolds</subject><subject>Streptococcus infections</subject><subject>wound dressing</subject><subject>Wound healing</subject><issn>1438-7492</issn><issn>1439-2054</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNqFkLFOwzAURS0EEqWwMltiTrGdpInHqhSK1IqhIEbLdpzWVWIH26F0Q3wB38iXkLYIRt7y3pXuvU86AFxiNMAIkeua12pAEM46kaEj0MNJTCOC0uR4f-dRllByCs68X6POltO4Bz4mlZLBWd-0Bi64KTZarr7ePxfBtTK0TsGxrRvrdVBwrmrhuFEeltbBZ9uaAt445b02S7iQvCxtVXi40WEFp3q5giMTtH3TBTcBdtV7LbgMymlewZEM-lWH7Tk4KXnl1cXP7oOn28njeBrNHu7ux6NZJOM0QVHCeYZLmnNOBEmpwIgQlSOCKR_mUqhUJDESIi2HOBU0S0U3XCa5kEWGFC3iPrg69DbOvrTKB7a2rTPdS0Z2PEiM86xzDQ4u2UHxTpWscbrmbsswYjvObMeZ_XLuAvQQ2OhKbf9xs_loPvnLfgN43IWw</recordid><startdate>201802</startdate><enddate>201802</enddate><creator>Li, Jinzhen</creator><creator>Hu, Yang</creator><creator>He, Ting</creator><creator>Huang, Mengwen</creator><creator>Zhang, Xiangchao</creator><creator>Yuan, Jinying</creator><creator>Wei, Yen</creator><creator>Dong, Xianming</creator><creator>Liu, Wei</creator><creator>Ko, Frank</creator><creator>Zhou, Wuyi</creator><general>John Wiley & Sons, Inc</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope></search><sort><creationdate>201802</creationdate><title>Electrospun Sandwich‐Structure Composite Membranes for Wound Dressing Scaffolds with High Antioxidant and Antibacterial Activity</title><author>Li, Jinzhen ; Hu, Yang ; He, Ting ; Huang, Mengwen ; Zhang, Xiangchao ; Yuan, Jinying ; Wei, Yen ; Dong, Xianming ; Liu, Wei ; Ko, Frank ; Zhou, Wuyi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3540-4aa71f98aa2b259b1022e80219a68cbe5b430bb5f615b975bbbbac48bcd70e9d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>antibacterial and antioxidant assays</topic><topic>Antioxidants</topic><topic>Biocompatibility</topic><topic>Drug delivery systems</topic><topic>drug release</topic><topic>E coli</topic><topic>Electrospinning</topic><topic>electrospun composite membrane</topic><topic>Fourier transforms</topic><topic>Free radicals</topic><topic>Membranes</topic><topic>Polylactic acid</topic><topic>Polyvinylidene fluorides</topic><topic>Pseudomonas aeruginosa</topic><topic>Sandwich structures</topic><topic>sandwich‐structure</topic><topic>Scaffolds</topic><topic>Streptococcus infections</topic><topic>wound dressing</topic><topic>Wound healing</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Jinzhen</creatorcontrib><creatorcontrib>Hu, Yang</creatorcontrib><creatorcontrib>He, Ting</creatorcontrib><creatorcontrib>Huang, Mengwen</creatorcontrib><creatorcontrib>Zhang, Xiangchao</creatorcontrib><creatorcontrib>Yuan, Jinying</creatorcontrib><creatorcontrib>Wei, Yen</creatorcontrib><creatorcontrib>Dong, Xianming</creatorcontrib><creatorcontrib>Liu, Wei</creatorcontrib><creatorcontrib>Ko, Frank</creatorcontrib><creatorcontrib>Zhou, Wuyi</creatorcontrib><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><jtitle>Macromolecular materials and engineering</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Jinzhen</au><au>Hu, Yang</au><au>He, Ting</au><au>Huang, Mengwen</au><au>Zhang, Xiangchao</au><au>Yuan, Jinying</au><au>Wei, Yen</au><au>Dong, Xianming</au><au>Liu, Wei</au><au>Ko, Frank</au><au>Zhou, Wuyi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Electrospun Sandwich‐Structure Composite Membranes for Wound Dressing Scaffolds with High Antioxidant and Antibacterial Activity</atitle><jtitle>Macromolecular materials and engineering</jtitle><date>2018-02</date><risdate>2018</risdate><volume>303</volume><issue>2</issue><epage>n/a</epage><issn>1438-7492</issn><eissn>1439-2054</eissn><abstract>In this study, the sandwich‐structured composite (SSC) membranes with well‐antibacterial and antioxidant properties, which have the promising application as wound dressing, are successfully fabricated by combining an electrospinning process. The SSC membranes are composed of three layers, including the bottom polyvinylidene fluoride fibrous layer, the middle curcumin/polylactic acid (PLA) microsphere layer, and the top enrofloxacin/PLA fibrous layer, respectively. The obtained SSC membranes are characterized in terms of morphology, component, and mechanical property using scanning electronic microscope, X‐ray diffractometer, Fourier transform infrared spectroscopy, and universal electronic testing machine, respectively. Moreover, in vitro drug release, antioxidant activity, antimicrobial activity, and biocompatibility of the SSC membranes are also evaluated. The results showed that the obtained composite membranes indeed possess the sandwich structure, where the middle microsphere layer is located between two fibrous surface layers. It is found that the drug‐loaded SSC membranes show excellent antioxidant activity against •OH and DPPH free radicals and antibacterial activity against Staphylococcus aureus, Escherichia coli, Streptococcus pneumoniae, Pseudomonas aeruginosa, and Candida albicans. The combination of electrospinning and electrospraying opens up a new way to fabricate a variety of composite membranes with a sandwich structure, which have promising potential application as wound dressing scaffolds.
Sandwich‐structured composite (SSC) membranes are successfully fabricated by combining an electrospinning process. The prepared SSC membranes show a hydrophobic surface and a hydrophilic surface, and possess well antibacterial and antioxidant properties. This study demonstrates an innovative strategy for creating SSC membranes, which have promising application prospects as wound dressings.</abstract><cop>Weinheim</cop><pub>John Wiley & Sons, Inc</pub><doi>10.1002/mame.201700270</doi><tpages>13</tpages></addata></record> |
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| subjects | antibacterial and antioxidant assays Antioxidants Biocompatibility Drug delivery systems drug release E coli Electrospinning electrospun composite membrane Fourier transforms Free radicals Membranes Polylactic acid Polyvinylidene fluorides Pseudomonas aeruginosa Sandwich structures sandwich‐structure Scaffolds Streptococcus infections wound dressing Wound healing |
| title | Electrospun Sandwich‐Structure Composite Membranes for Wound Dressing Scaffolds with High Antioxidant and Antibacterial Activity |
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