Effects of ovariectomy on autophagy and senile plaques in the brain of adult APP/PS1 double transgenic mice
Objective To investigate the effect of ovarian estrogen on autophagy and senile plaques (SP) in the brain of adult APP/PS1 double transgenic mice, and inquire into the mechanism of Alzheimer disease (AD) neuropathogenesis due to estrogen deficiency. Methods APP/PS1 AD mice (3-month old) were divided...
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| Veröffentlicht in: | Jie fang jun yi xue za zhi 2015-01, Vol.40 (1), p.26 |
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| creator | Ming-liang, XU Zhi-min LONG Liao, E Guo-chao, ZHONG Ye-hong, DU Shi-fang, LUO HE, Gui-qiong |
| description | Objective To investigate the effect of ovarian estrogen on autophagy and senile plaques (SP) in the brain of adult APP/PS1 double transgenic mice, and inquire into the mechanism of Alzheimer disease (AD) neuropathogenesis due to estrogen deficiency. Methods APP/PS1 AD mice (3-month old) were divided into ovariectomy group (OVX-AD) and sham group (sham-AD). Two months after operation, transmission electron microscopy (TEM) was employed to observe the morphological structures of the brains of AD model mice, and immunohistochemical staining was performed to examine the changes in SP and autophagy-related proteins LC3 and Beclin-1 in the brain of AD model mice. Results Immunohistochemical staining showed that the number of SP in the brain of OVX-AD mice incrcased significantly compared with that in sham-AD mice, and distribution of SP was observed more extensively, including the cortex and hippocampus. The autophagy related proteins LC3 and Beclin-1 positive neurons were decreased greatly in the OVX-AD mice brain |
| doi_str_mv | 10.11855/j.issn.0577-7402.2015.01.06 |
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Methods APP/PS1 AD mice (3-month old) were divided into ovariectomy group (OVX-AD) and sham group (sham-AD). Two months after operation, transmission electron microscopy (TEM) was employed to observe the morphological structures of the brains of AD model mice, and immunohistochemical staining was performed to examine the changes in SP and autophagy-related proteins LC3 and Beclin-1 in the brain of AD model mice. Results Immunohistochemical staining showed that the number of SP in the brain of OVX-AD mice incrcased significantly compared with that in sham-AD mice, and distribution of SP was observed more extensively, including the cortex and hippocampus. The autophagy related proteins LC3 and Beclin-1 positive neurons were decreased greatly in the OVX-AD mice brain</description><identifier>ISSN: 0577-7402</identifier><identifier>DOI: 10.11855/j.issn.0577-7402.2015.01.06</identifier><language>chi</language><publisher>Beijing: People's Military Medical Press</publisher><subject>Autophagy ; Brain ; Estrogens ; Rodents ; Transgenic animals</subject><ispartof>Jie fang jun yi xue za zhi, 2015-01, Vol.40 (1), p.26</ispartof><rights>2015] This work is licensed under [CC BY 3.0 Unported - https://creativecommons.org/licenses/by/3.0/ (“the License”). 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Methods APP/PS1 AD mice (3-month old) were divided into ovariectomy group (OVX-AD) and sham group (sham-AD). Two months after operation, transmission electron microscopy (TEM) was employed to observe the morphological structures of the brains of AD model mice, and immunohistochemical staining was performed to examine the changes in SP and autophagy-related proteins LC3 and Beclin-1 in the brain of AD model mice. Results Immunohistochemical staining showed that the number of SP in the brain of OVX-AD mice incrcased significantly compared with that in sham-AD mice, and distribution of SP was observed more extensively, including the cortex and hippocampus. 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Methods APP/PS1 AD mice (3-month old) were divided into ovariectomy group (OVX-AD) and sham group (sham-AD). Two months after operation, transmission electron microscopy (TEM) was employed to observe the morphological structures of the brains of AD model mice, and immunohistochemical staining was performed to examine the changes in SP and autophagy-related proteins LC3 and Beclin-1 in the brain of AD model mice. Results Immunohistochemical staining showed that the number of SP in the brain of OVX-AD mice incrcased significantly compared with that in sham-AD mice, and distribution of SP was observed more extensively, including the cortex and hippocampus. The autophagy related proteins LC3 and Beclin-1 positive neurons were decreased greatly in the OVX-AD mice brain</abstract><cop>Beijing</cop><pub>People's Military Medical Press</pub><doi>10.11855/j.issn.0577-7402.2015.01.06</doi></addata></record> |
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| title | Effects of ovariectomy on autophagy and senile plaques in the brain of adult APP/PS1 double transgenic mice |
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