Effects of regional seawater immersion on the pain behavior and secondary neuropathological change in the rats model of skin/muscle incision and retraction

Objective  To evaluate the effects of regional seawater immersion on the pain behavior and its secondary neuropathological change in the rats model of skin/muscle incision and retraction (SMIR). Methods  Forty-eight male SD rats were randomly assigned into 3 groups (16 each): the model control group...

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Veröffentlicht in:Jie fang jun yi xue za zhi 2016-07, Vol.41 (7), p.555
Hauptverfasser: Rong-fang, DENG, Xi-zhao, HUANG, Xue-fei WEN, Wei-feng, TU
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Xi-zhao, HUANG
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description Objective  To evaluate the effects of regional seawater immersion on the pain behavior and its secondary neuropathological change in the rats model of skin/muscle incision and retraction (SMIR). Methods  Forty-eight male SD rats were randomly assigned into 3 groups (16 each): the model control group (only to set up SMIR model, Group MC), normal saline immersion group (to set up SMIR model and the incision immersed with normal saline, Group NS), seawater immersion group (to set up SMIR model and the incision immersed with seawater, Group SW). Mechanical paw withdrawal threshold (MWT) was measured 1d before and 1d, 3d, 5d, 7d, 14d, 21d and 28d after operation, respectively. At 3d and 28d after the operation, 8 rats were randomly selected from each group, ipsilateral saphenous nerves were taken from 4 rats for HE staining, and dorsal root ganglion of ipsilateral L3/L4 were taken from another 4 rats for ultrastructural observation by electron microscopy. Results  Compared with the other two groups, MWT values in
doi_str_mv 10.11855/j.issn.0577-7402.2016.07.07
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Pain
Rodents
title Effects of regional seawater immersion on the pain behavior and secondary neuropathological change in the rats model of skin/muscle incision and retraction
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