Ultraviolet B irradiation of human skin induces an angiogenic switch that is mediated by upregulation of vascular endothelial growth factor and by downregulation of thrombospondin-1

Summary Background We have previously demonstrated that skin‐specific overexpression of the endogenous angiogenesis inhibitor thrombospondin (TSP)‐1 prevented chronic ultraviolet (UV) B‐induced angiogenesis, inflammatory cell infiltration and cutaneous photodamage in mice. Objectives To elucidate...

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Veröffentlicht in:	British journal of dermatology (1951) 2005-01, Vol.152 (1), p.115-121
Hauptverfasser:	Yano, K., Kadoya, K., Kajiya, K., Hong, Y-K., Detmar, M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult angiogenesis Biological and medical sciences Dermatology Down-Regulation - radiation effects Elastic Tissue - radiation effects Epidermis - metabolism Epidermis - pathology Humans Hyperplasia Image Processing, Computer-Assisted - methods Leukocytes - enzymology Medical sciences Middle Aged Neovascularization, Pathologic - etiology Neovascularization, Pathologic - metabolism Neovascularization, Pathologic - pathology neutrophil elastase Pancreatic Elastase - biosynthesis Radiation Injuries - etiology Radiation Injuries - metabolism Radiation Injuries - pathology Reverse Transcriptase Polymerase Chain Reaction - methods Skin - blood supply Skin - radiation effects Skin Aging - pathology Thrombospondin 1 - biosynthesis Thrombospondin 1 - genetics thrombospondin-1 ultraviolet B Ultraviolet Rays - adverse effects Up-Regulation - radiation effects vascular endothelial growth factor Vascular Endothelial Growth Factor A - biosynthesis Vascular Endothelial Growth Factor A - genetics
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